STRINGSTRING
MECR MECR CPT2 CPT2 HACD1 HACD1 SCD SCD ELOVL3 ELOVL3 HSD17B12 HSD17B12 ACAT1 ACAT1 ACADS ACADS ACSBG1 ACSBG1 FASN FASN ACAA2 ACAA2 ACSBG2 ACSBG2 HADHA HADHA HADHB HADHB ACADL ACADL ACSL3 ACSL3 MCAT MCAT ACAA1 ACAA1 EHHADH EHHADH SCD5 SCD5 ELOVL6 ELOVL6 ACSL1 ACSL1 ELOVL7 ELOVL7 PPT2 PPT2 HSD17B8 HSD17B8 ACAT2 ACAT2 ACSL4 ACSL4 ACSL5 ACSL5 FADS1 FADS1 CPT1B CPT1B CBR4 CBR4 CPT1C CPT1C HACD2 HACD2 HTD2 HTD2 HADH HADH HSD17B4 HSD17B4 ELOVL2 ELOVL2 ACADVL ACADVL ACOX1 ACOX1 CPT1A CPT1A ACACA ACACA ACSF3 ACSF3 ACADSB ACADSB ELOVL4 ELOVL4 OXSM OXSM ACSL6 ACSL6 HACD4 HACD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MECRMitochondrial trans-2-enoyl-CoA reductase. (297 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (288 aa)
SCDStearoyl-CoA desaturase (Delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. (359 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
HSD17B12Hydroxysteroid (17-beta) dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
ACADSAcyl-CoA dehydrogenase, C-2 to C-3 short chain. (412 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (724 aa)
FASNFatty acid synthase. (2511 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ACSBG2ACSBG2 isoform 5. (666 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
HADHBTrifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] (475 aa)
ACADLAcyl-CoA dehydrogenase long chain. (430 aa)
ACSL3Acyl-CoA synthetase long-chain family member 3. (720 aa)
MCATMalonyl CoA:ACP acyltransferase (Mitochondrial). (390 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
ACSL1ACSL1 isoform 9. (698 aa)
ELOVL7Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa)
PPT2PPT2-EGFL8 isoform 1. (308 aa)
HSD17B8Hydroxysteroid (17-beta) dehydrogenase 8. (261 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ACSL4Acyl-CoA synthetase long-chain family member 4. (749 aa)
ACSL5Acyl-CoA synthetase long-chain family member 5. (739 aa)
FADS1Fatty acid desaturase 1. (501 aa)
CPT1BCPT1B isoform 2; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
CBR4Carbonyl reductase 4. (237 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (254 aa)
HTD2Ribonuclease P/MRP 14kDa subunit. (164 aa)
HADHHydroxyacyl-CoA dehydrogenase. (390 aa)
HSD17B4Hydroxysteroid (17-beta) dehydrogenase 4. (809 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (326 aa)
ACADVLAcyl-CoA dehydrogenase, very long chain. (677 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
ACSF3ACSF3 isoform 1. (576 aa)
ACADSBAcyl-CoA dehydrogenase, short/branched chain. (434 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (307 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (459 aa)
ACSL6T0093412 isoform 1. (722 aa)
HACD4Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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