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ENO1 ENO1 CTH CTH PHGDH PHGDH GLUL GLUL PFKP PFKP MAT1A MAT1A PGAM1 PGAM1 GOT1 GOT1 TALDO1 TALDO1 GAPDH GAPDH CS CS PAH PAH SDS SDS SDSL SDSL ARG2 ARG2 GPT2 GPT2 GOT2 GOT2 ENO3 ENO3 ALDOC ALDOC NAGS NAGS MAT2A MAT2A RPIA RPIA CBS CBS ACO2 ACO2 TKTL2 TKTL2 MAT2B MAT2B PGK1 PGK1 ARG1 ARG1 PSPH PSPH ASNS ASNS PYCR3 PYCR3 ACO1 ACO1 PSAT1 PSAT1 ASS1 ASS1 OTC OTC PRPS1 PRPS1 GPT GPT PFKL PFKL PYCR1 PYCR1 PC PC MTR MTR PFKM PFKM PKLR PKLR IDH3G IDH3G TPI1 TPI1 BCAT1 BCAT1 SHMT2 SHMT2 LOC104002294 LOC104002294 ALDOA ALDOA ENO2 ENO2 PGAM2-2 PGAM2-2 IDH3A IDH3A LOC465383-2 LOC465383-2 ALDOB ALDOB ENO4 ENO4 TKT TKT IDH3B IDH3B IDH2 IDH2 ALDH18A1 ALDH18A1 IDH1 IDH1 TKTL1 TKTL1 RPE RPE PYCR2 PYCR2 CPS1 CPS1 LOC455744 LOC455744 PKM PKM GOT1L1 GOT1L1 PRPS2 PRPS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENO1ENO1 isoform 2. (434 aa)
CTHCystathionase (Cystathionine gamma-lyase). (405 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (573 aa)
GLULGlutamine synthetase. (373 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (862 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
PGAM1Probable phosphoglycerate mutase 4. (254 aa)
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
CSCitrate synthase, mitochondrial isoform X1. (466 aa)
PAHPhenylalanine hydroxylase. (452 aa)
SDSSerine dehydratase. (328 aa)
SDSLSerine dehydratase-like. (329 aa)
ARG2Arginase. (354 aa)
GPT2Glutamic pyruvate transaminase (Alanine aminotransferase) 2. (523 aa)
GOT2Aspartate aminotransferase. (430 aa)
ENO3Enolase 3 (Beta, muscle). (434 aa)
ALDOCFructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
NAGSN-acetylglutamate synthase. (534 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
RPIARibose 5-phosphate isomerase A. (311 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
ACO2ACO2 isoform 2. (800 aa)
TKTL2TKTL2 isoform 1. (722 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (334 aa)
PGK1Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (459 aa)
ARG1Arginase. (322 aa)
PSPHPhosphoserine phosphatase. (225 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (286 aa)
ACO1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (889 aa)
PSAT1Phosphoserine aminotransferase. (370 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
PRPS1Phosphoribosyl pyrophosphate synthetase 1. (318 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1267 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
TPI1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (286 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
LOC104002294LOW QUALITY PROTEIN: pyruvate kinase PKM-like. (501 aa)
ALDOAFructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. (729 aa)
ENO2Enolase 2 (Gamma, neuronal). (434 aa)
PGAM2-2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (373 aa)
LOC465383-2Uncharacterized protein. (72 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
ENO4ENO4 isoform 3. (629 aa)
TKTTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (631 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (408 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (424 aa)
TKTL1TKTL1 isoform 3. (598 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (252 aa)
PYCR2PYCR1 isoform 17. (320 aa)
CPS1Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)
LOC455744LOW QUALITY PROTEIN: phosphoglycerate kinase 1-like. (408 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
GOT1L1GOT1L1 isoform 1. (415 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (321 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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