STRINGSTRING
MTOR MTOR JAK1 JAK1 NRAS NRAS IL6R IL6R HRAS HRAS RPS6KB2 RPS6KB2 ERBB3 ERBB3 SHC4 SHC4 IGF1R IGF1R PRKCB PRKCB NF1 NF1 RPS6KB1 RPS6KB1 PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 PRKCG PRKCG BCL2L1 BCL2L1 PLCG1 PLCG1 MAPK1 MAPK1 PDGFB PDGFB PIK3CB PIK3CB PDGFRA PDGFRA KDR KDR EGF EGF GAB1 GAB1 NRG2 NRG2 SOS2 SOS2 EIF4E1B EIF4E1B FOXO3 FOXO3 SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 PDGFA PDGFA RPS6 RPS6 MAP2K1 MAP2K1 SHC3 SHC3 PIK3R3 PIK3R3 FGF2 FGF2 IGF1 IGF1 IL6 IL6 EIF4E EIF4E EGFR EGFR ERBB2 ERBB2 HGF HGF BCL2L11 BCL2L11 PLCG2 PLCG2 SRC SRC PIK3R1 PIK3R1 PDGFD PDGFD BRAF BRAF PDGFRB PDGFRB GSK3B GSK3B AKT1 AKT1 MET MET ARAF ARAF KRAS KRAS AKT3 AKT3 AXL AXL FGFR3 FGFR3 AKT2 AKT2 BCL2 BCL2 PDGFC PDGFC STAT3 STAT3 NRG1 NRG1 BAX BAX VEGFA VEGFA EIF4E2 EIF4E2 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
IL6RInterleukin 6 receptor. (442 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
SHC4SHC adaptor protein 4. (630 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
NF1Neurofibromin 1. (2839 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
NRG2NRG2 isoform 3. (859 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
FOXO3FOXO3 isoform 1. (673 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
NRG1NRG1 isoform 3. (713 aa)
BAXBAX isoform 7. (123 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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