STRINGSTRING
EPHA2 EPHA2 PLA2G2E PLA2G2E PLA2G5 PLA2G5 PLA2G2D PLA2G2D PLA2G2F PLA2G2F NRAS NRAS EFNA4 EFNA4 EFNA3 EFNA3 EFNA1 EFNA1 FASLG FASLG RASAL2 RASAL2 RGL1 RGL1 PLA2G4A PLA2G4A GNG4 GNG4 CALML5 CALML5 PLA2G12B PLA2G12B HTR7 HTR7 SHOC2 SHOC2 HRAS HRAS RRAS2 RRAS2 GNG3 GNG3 PLAAT2 PLAAT2 RASGRP2 RASGRP2 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 PAK1 PAK1 FGF23 FGF23 GRIN2B GRIN2B RAB5B RAB5B TBK1 TBK1 BRAP BRAP RASAL1 RASAL1 KSR2 KSR2 PLA2G1B PLA2G1B FGF9 FGF9 FLT3 FLT3 FLT1 FLT1 PAK6 PAK6 PLA2G4E PLA2G4E PLA2G4D PLA2G4D SHC4 SHC4 FGF7 FGF7 GNB5 GNB5 IGF1R IGF1R PRKCB PRKCB PLD2 PLD2 NF1 NF1 NGFR NGFR PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 PRKACA PRKACA PIK3R2 PIK3R2 CALM3 CALM3 FGF21 FGF21 NTF4 NTF4 RRAS RRAS PRKCG PRKCG RASGRP3 RASGRP3 ZAP70 ZAP70 ANGPT4 ANGPT4 PAK5 PAK5 BCL2L1 BCL2L1 PLCG1 PLCG1 TIAM1 TIAM1 MAPK1 MAPK1 PLA2G3 PLA2G3 PDGFB PDGFB RAB5A RAB5A RHOA RHOA PLA1A PLA1A MRAS MRAS PIK3CB PIK3CB RASA2 RASA2 GNB4 GNB4 PDGFRA PDGFRA KIT KIT KDR KDR NFKB1 NFKB1 EGF EGF GAB1 GAB1 VEGFC VEGFC RASA1 RASA1 FGF1 FGF1 FGFR4 FGFR4 MAPK9 MAPK9 EXOC2 EXOC2 RGL2 RGL2 RALA RALA GNGT1 GNGT1 GNG11 GNG11 ANGPT2 ANGPT2 IKBKB IKBKB PRKACG PRKACG GNG10 GNG10 RALGDS RALGDS VEGFD VEGFD ELK1 ELK1 MAPK8 MAPK8 PRKACB PRKACB FGF17 FGF17 PLD1 PLD1 ETS2 ETS2 RASSF1 RASSF1 SOS2 SOS2 CALML6 CALML6 FGF16 FGF16 GNB3 GNB3 FLT4 FLT4 GAB2 GAB2 RIN1 RIN1 VEGFB VEGFB EFNA2 EFNA2 RALBP1 RALBP1 RASSF5 RASSF5 SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 RELA RELA PLCE1 PLCE1 GRIN2A GRIN2A RAPGEF5 RAPGEF5 LAT LAT RASAL3 RASAL3 PDGFA PDGFA BDNF BDNF GNGT2 GNGT2 LOC749464 LOC749464 PTPN11 PTPN11 AFDN AFDN SYNGAP1 SYNGAP1 GNG12 GNG12 PAK3 PAK3 GNG13 GNG13 STK4 STK4 MAP2K1 MAP2K1 INSR INSR SHC3 SHC3 PIK3R3 PIK3R3 PLA2G12A PLA2G12A CALML3 CALML3 GNG2 GNG2 FGF22 FGF22 FGFR1 FGFR1 GNB1 GNB1 FGF2 FGF2 IGF1 IGF1 GNG7 GNG7 ARF6 ARF6 EGFR EGFR MAPK10 MAPK10 TEK TEK NGF NGF RAP1B RAP1B RASGRP4 RASGRP4 HGF HGF RASGRP1 RASGRP1 ABL1 ABL1 RALB RALB RASA4 RASA4 FGF8 FGF8 LOC100610002 LOC100610002 PLCG2 PLCG2 PIK3R1 PIK3R1 NTRK2 NTRK2 CDC42 CDC42 RASGRF1 RASGRF1 PDGFD PDGFD RAB5C RAB5C IGF2 IGF2 PDGFRB PDGFRB CSF1R CSF1R PLAAT3 PLAAT3 BV7-9 BV7-9 AKT1 AKT1 LOC751039 LOC751039 MET MET NTRK1 NTRK1 FGF10 FGF10 CHUK CHUK KRAS KRAS RAP1A RAP1A GNB2 GNB2 FGF6 FGF6 REL REL FGF20 FGF20 AKT3 AKT3 ETS1 ETS1 PLA2G2A PLA2G2A FGFR3 FGFR3 AKT2 AKT2 NTF3 NTF3 PLA2G4F PLA2G4F PAK4 PAK4 GNG8 GNG8 PDGFC PDGFC LOC739070 LOC739070 FGF18 FGF18 ANGPT1 ANGPT1 PLA2G10 PLA2G10 VEGFA VEGFA ABL2 ABL2 BAD BAD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA2EPH receptor A2. (976 aa)
PLA2G2EPhospholipase A(2). (142 aa)
PLA2G5Phospholipase A(2). (138 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PLA2G2FPhospholipase A(2). (211 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
EFNA4EFNA4 isoform 1; Belongs to the ephrin family. (201 aa)
EFNA3Ephrin-A3 isoform X1. (238 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
RASAL2RAS protein activator like 2. (1280 aa)
RGL1Ral guanine nucleotide dissociation stimulator-like 1. (803 aa)
PLA2G4APhospholipase A2. (749 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CALML5Calmodulin like 5. (146 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
HTR7HTR7 isoform 2; Belongs to the G-protein coupled receptor 1 family. (492 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
RRAS2Related RAS viral (R-ras) oncogene homolog 2. (204 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLAAT2HRASLS2 isoform 1. (162 aa)
RASGRP2RAS guanyl releasing protein 2. (609 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
RAB5BRAB5B, member RAS oncogene family. (227 aa)
TBK1TANK-binding kinase 1. (729 aa)
BRAPBRCA1-associated protein. (592 aa)
RASAL1RAS protein activator like 1. (806 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
PLA2G1BPhospholipase A(2). (148 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLA2G4DPhospholipase A2. (818 aa)
SHC4SHC adaptor protein 4. (630 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GNB5GNB5 isoform 1. (409 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLD2Phospholipase. (933 aa)
NF1Neurofibromin 1. (2839 aa)
NGFRNerve growth factor receptor. (427 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
NTF4NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
RRASRelated RAS viral (R-ras) oncogene homolog. (218 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
ANGPT4ANGPT4 isoform 1. (503 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLA2G3PLA2G3 isoform 1. (509 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
RHOARas homolog family member A. (193 aa)
PLA1APhospholipase A1 member A. (456 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RASA2RAS p21 protein activator 2. (849 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
RGL2Ral guanine nucleotide dissociation stimulator-like 2. (777 aa)
RALAV-ral simian leukemia viral oncogene homolog A (Ras related). (206 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (914 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PLD1Phospholipase. (1074 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
RASSF1Ras association (RalGDS/AF-6) domain family member 1. (340 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML6Calmodulin like 6. (181 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GNB3G protein subunit beta 3. (340 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
RIN1Ras and Rab interactor 1. (783 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
EFNA2EFNA2 isoform 1; Belongs to the ephrin family. (190 aa)
RALBP1RalA binding protein 1. (655 aa)
RASSF5Ras association (RalGDS/AF-6) domain family member 5. (418 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
LATLinker for activation of T cells. (268 aa)
RASAL3RASAL3 isoform 1. (1011 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
LOC749464Phospholipase A2. (781 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
AFDNAfadin, adherens junction formation factor. (1834 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
PLA2G12APhospholipase A2, group XIIA. (189 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
RASGRP4RAS guanyl releasing protein 4. (699 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
RASGRP1RASGRP1 isoform 4. (848 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RALBV-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein). (212 aa)
RASA4Ras-GAP domain-containing protein. (757 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
LOC100610002IKBKG isoform 9. (401 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
RAB5CT0136450 isoform 1. (249 aa)
IGF2Insulin like growth factor 2. (236 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
PLAAT3Uncharacterized protein. (170 aa)
BV7-9TRBV7-9 isoform 1. (155 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
LOC751039Uncharacterized protein. (613 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RELREL isoform 1. (619 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
PLA2G2APhospholipase A(2). (144 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
PLA2G4FPhospholipase A2. (849 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC739070PLA2G10 isoform 1. (165 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
PLA2G10Group 10 secretory phospholipase A2-like. (165 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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