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| | FGR | Tyrosine-protein kinase. (529 aa) |
| | GNAI3 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | GRK5 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | RASGRP2 | RAS guanyl releasing protein 2. (609 aa) |
| | GRK2 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (553 aa) |
| | GRK1 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (563 aa) |
| | ADCY4 | Adenylate cyclase type 4 isoform X1. (1077 aa) |
| | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | GNB5 | GNB5 isoform 1. (409 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | CX3CL1 | Chemokine (C-X3-C motif) ligand 1. (397 aa) |
| | ARRB2 | ARRB2 isoform 2. (430 aa) |
| | PIK3R5 | Phosphoinositide-3-kinase regulatory subunit 5. (882 aa) |
| | CCL8 | C-C motif chemokine. (109 aa) |
| | CCL1 | C-C motif chemokine. (96 aa) |
| | CCL16 | C-C motif chemokine. (120 aa) |
| | CCL15 | C-C motif chemokine. (113 aa) |
| | CCL23 | C-C motif chemokine. (137 aa) |
| | CCR10 | C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | CCL25 | C-C motif chemokine ligand 25. (150 aa) |
| | PRKACA | PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha. (483 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa) |
| | CXCR1 | C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. (350 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | HCK | Tyrosine-protein kinase. (526 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa) |
| | TIAM1 | T-cell lymphoma invasion and metastasis 1. (1591 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | CCR4 | C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | CCR9 | C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa) |
| | CCR2 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | GNAI2 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | ADCY5 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | GNB4 | Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | CXCL6 | C-X-C motif chemokine. (114 aa) |
| | CXCL1 | C-X-C motif chemokine. (107 aa) |
| | PF4 | C-X-C motif chemokine. (101 aa) |
| | PPBP | C-X-C motif chemokine. (128 aa) |
| | CXCL5 | C-X-C motif chemokine. (114 aa) |
| | CXCL3 | C-X-C motif chemokine. (107 aa) |
| | CXCL9 | C-X-C motif chemokine. (125 aa) |
| | CXCL10 | C-X-C motif chemokine. (96 aa) |
| | CXCL11 | C-X-C motif chemokine. (94 aa) |
| | CXCL13 | C-X-C motif chemokine. (109 aa) |
| | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa) |
| | CXCL14 | Chemokine (C-X-C motif) ligand 14. (111 aa) |
| | ITK | Tyrosine-protein kinase. (620 aa) |
| | DOCK2 | Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa) |
| | NCF1 | Neutrophil cytosolic factor 1. (390 aa) |
| | CCL26 | C-C motif chemokine. (94 aa) |
| | CCL24 | C-C motif chemokine ligand 24. (119 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | PTK2B | PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | CCL27 | C-C motif chemokine ligand 27. (112 aa) |
| | CCL19 | C-C motif chemokine. (98 aa) |
| | CCL21 | C-C motif chemokine ligand 21. (134 aa) |
| | PRKACG | Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa) |
| | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa) |
| | CXCR3 | C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa) |
| | CCR3 | C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | PARD3 | PARD3 isoform 2. (1356 aa) |
| | ARRB1 | ARRB1 isoform 1. (418 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | CCL20 | C-C motif chemokine. (96 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | GNB3 | G protein subunit beta 3. (340 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | CRKL | V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa) |
| | GNAQ | Guanine nucleotide binding protein (G protein), q polypeptide. (359 aa) |
| | FOXO3 | FOXO3 isoform 1. (673 aa) |
| | GRK3 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa) |
| | XCR1 | X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa) |
| | SHC1 | SHC (Src homology 2 domain containing) transforming protein 1. (584 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | CCL7 | C-C motif chemokine. (109 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) |
| | CXCR6 | C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. (342 aa) |
| | CCL18 | C-C motif chemokine. (89 aa) |
| | CCL3 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa) |
| | NFKBIB | NFKB inhibitor beta. (270 aa) |
| | CCL4 | C-C motif chemokine. (92 aa) |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa) |
| | GNG13 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | SHC3 | SHC3 isoform 2. (598 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | CCL13 | C-C motif chemokine. (98 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa) |
| | GRK7 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa) |
| | GNB1 | Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa) |
| | CXCL12 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa) |
| | WAS | WAS isoform 1. (502 aa) |
| | CCL2 | C-C motif chemokine. (109 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | RAP1B | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa) |
| | GNAI1 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa) |
| | ELMO1 | Engulfment and cell motility 1. (769 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa) |
| | CCL28 | C-C motif chemokine. (127 aa) |
| | CXCR2 | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (360 aa) |
| | LOC100610002 | IKBKG isoform 9. (401 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | CCR1 | C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | CDC42 | Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa) |
| | CCL22 | C-C motif chemokine. (93 aa) |
| | PF4V1 | C-X-C motif chemokine. (104 aa) |
| | BRAF | BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (916 aa) |
| | CXCL2 | C-X-C motif chemokine. (117 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa) |
| | PREX1 | Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1. (1659 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | CCL5 | C-C motif chemokine. (91 aa) |
| | CRK | V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) |
| | CCL17 | C-C motif chemokine. (94 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa) |
| | GRK6 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (650 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa) |
| | LOC112204135 | X-C motif chemokine ligand 1. (114 aa) |
| | LOC747332 | T0050420 isoform 2. (87 aa) |
| | GNB2 | Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LOC455004 | CCL4L2 isoform 3. (103 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | VAV3 | VAV3 isoform 2. (927 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | CCL11 | C-C motif chemokine. (97 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
