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| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | SIRT1 | SIRT1 isoform 2. (751 aa) |
| | BNIP3 | BCL2 interacting protein 3. (259 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | CCND2 | CCND2 isoform 1; Belongs to the cyclin family. (289 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa) |
| | PRKAB1 | Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa) |
| | FOXO1 | FOXO1 isoform 1. (655 aa) |
| | IRS2 | IRS2 isoform 1. (1340 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CCNB2 | CCNB2 isoform 1; Belongs to the cyclin family. (398 aa) |
| | HOMER2 | Homer scaffold protein 2. (356 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1364 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | SLC2A4 | SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | G6PC3 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | KLF2 | Kruppel-like factor 2 (Lung). (355 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | HOMER3 | HOMER1 isoform 2. (361 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa) |
| | PRKAG3 | PRKAG3 isoform 1. (489 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | SGK2 | Serine/threonine-protein kinase Sgk2 isoform X1. (429 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | EP300 | E1A binding protein p300. (2175 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | CCNG2 | CCNG2 isoform 1; Belongs to the cyclin family. (344 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa) |
| | PLK4 | Polo-like kinase 4. (970 aa) |
| | SKP2 | S-phase kinase-associated protein 2 (P45). (425 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (685 aa) |
| | CCNB1 | CCNB1 isoform 1; Belongs to the cyclin family. (433 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | GRM1 | Glutamate receptor, metabotropic 1. (1194 aa) |
| | FBXO25 | F-box protein 25. (367 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | GADD45G | Growth arrest and DNA-damage-inducible, gamma. (159 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (282 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | FOXO3 | FOXO3 isoform 1. (673 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | FOXG1 | FOXG1 isoform 8. (489 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (370 aa) |
| | LOC467760 | Gamma-aminobutyric acid receptor-associated protein-like 3. (117 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | STK4 | Serine/threonine-protein kinase 4. (487 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1408 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | FBXO32 | F-box protein 32. (355 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa) |
| | CCNB3 | CCNB3 isoform 4; Belongs to the cyclin family. (1396 aa) |
| | IGF1 | Insulin-like growth factor 1 (Somatomedin C). (196 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | PRMT1 | Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1139 aa) |
| | GADD45B | Growth arrest and DNA-damage-inducible, beta. (160 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa) |
| | PRKAG2-2 | PRKAG2 isoform 10. (204 aa) |
| | PRKAB2 | Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa) |
| | BRAF | BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa) |
| | IRS4 | Insulin receptor substrate 4. (1257 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | CDKN2B | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa) |
| | GABARAPL1 | GABA type A receptor associated protein like 1. (117 aa) |
| | SOD2 | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa) |
| | ARAF | V-raf murine sarcoma 3611 viral oncogene homolog. (606 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (526 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) |
| | FOXO6 | FOXO6 isoform 2. (559 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CSNK1E | Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (419 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | PRKAG1 | PRKAG1 isoform 12. (333 aa) |
