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MAD2L2 MAD2L2 CDC20 CDC20 CALML5 CALML5 SLK SLK PPP2R5B PPP2R5B PGR PGR PPP2R1B PPP2R1B ESPL1 ESPL1 ANAPC5 ANAPC5 ADCY4 ADCY4 PPP2R5C PPP2R5C CCNB2 CCNB2 IGF1R IGF1R PKMYT1 PKMYT1 ADCY9 ADCY9 YWHAE YWHAE SPDYE4 SPDYE4 PRKACA PRKACA CALM3 CALM3 YWHAQ YWHAQ ADCY3 ADCY3 AURKA AURKA MAPK1 MAPK1 YWHAH YWHAH RBX1 RBX1 ITPR2 ITPR2 ITPR1 ITPR1 ADCY5 ADCY5 ANAPC13 ANAPC13 ANAPC4 ANAPC4 MAD2L1 MAD2L1 CCNB1 CCNB1 CDC23 CDC23 PTTG1 PTTG1 CPEB4 CPEB4 ITPR3 ITPR3 MAPK14 MAPK14 PPP2R5D PPP2R5D FBXO5 FBXO5 ADCY1 ADCY1 YWHAG YWHAG STAG3 STAG3 CUL1 CUL1 MOS MOS PRKACG PRKACG CDC26 CDC26 ANAPC2 ANAPC2 SMC1A SMC1A CPEB2 CPEB2 PRKACB PRKACB SMC3 SMC3 CALML6 CALML6 CDC25C CDC25C CK820_G0047526 CK820_G0047526 ENSPTRP00000047752 ENSPTRP00000047752 CDK1 CDK1 YWHAB YWHAB FBXO43 FBXO43 CCNE2 CCNE2 MAPK3 MAPK3 MAPK12 MAPK12 MAD1L1 MAD1L1 CK820_G0055452 CK820_G0055452 ENSPTRP00000060672 ENSPTRP00000060672 LOC742265 LOC742265 CDC16 CDC16 ADCY7 ADCY7 SPDYC SPDYC MAP2K1 MAP2K1 RPS6KA2 RPS6KA2 PPP2CA PPP2CA CALML3 CALML3 PPP3CB PPP3CB PPP3CA PPP3CA IGF1 IGF1 ENSPTRP00000068204 ENSPTRP00000068204 PPP1CB PPP1CB ANAPC10 ANAPC10 PLCZ1 PLCZ1 SKP1 SKP1 ANAPC1 ANAPC1 RPS6KA6 RPS6KA6 CAMK2B CAMK2B YWHAZ YWHAZ PPP3CC PPP3CC MAPK11 MAPK11 BUB1 BUB1 AR AR BTRC BTRC ADCY8 ADCY8 PPP1CC PPP1CC CPEB3 CPEB3 PPP2R5A PPP2R5A CAMK2A CAMK2A CPEB1 CPEB1 RPS6KA3 RPS6KA3 CDC27 CDC27 PPP2R1A PPP2R1A ADCY2 ADCY2 CCNE1 CCNE1 PPP2CB PPP2CB REC8 REC8 RPS6KA1 RPS6KA1 PTTG2 PTTG2 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
CDC20Cell division cycle 20 homolog. (499 aa)
CALML5Calmodulin like 5. (146 aa)
SLKSTE20 like kinase. (1236 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2118 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
CCNB2CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
PKMYT1PKMYT1 isoform 8. (565 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
SPDYE4Speedy/RINGO cell cycle regulator family member E4. (237 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (253 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
MAD2L1MAD2 mitotic arrest deficient-like 1. (205 aa)
CCNB1CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
CDC23Cell division cycle 23 homolog. (597 aa)
PTTG1Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
FBXO5F-box protein 5. (447 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family. (247 aa)
STAG3Stromal antigen 3. (1225 aa)
CUL1CUL1 isoform 1; Belongs to the cullin family. (776 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
CDC26Cell division cycle 26 homolog. (85 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1036 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
CALML6Calmodulin like 6. (181 aa)
CDC25CCDC25C isoform 7. (508 aa)
CK820_G0047526SPDYE6 isoform 1. (376 aa)
ENSPTRP00000047752LOW QUALITY PROTEIN: speedy protein E2-like. (376 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
FBXO43F-box protein 43. (708 aa)
CCNE2CCNE2 isoform 1; Belongs to the cyclin family. (404 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAD1L1MAD1 mitotic arrest deficient-like 1. (718 aa)
CK820_G0055452SPDYE2 isoform 1. (376 aa)
ENSPTRP00000060672Speedy protein E1. (376 aa)
LOC742265SPDYE5 isoform 3. (336 aa)
CDC16Cell division cycle 16 homolog. (620 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (305 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
RPS6KA2Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ENSPTRP0000006820414-3-3 protein homolog 1-like. (78 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PLCZ1Phosphoinositide phospholipase C. (639 aa)
SKP1T0093123 isoform 1; Belongs to the SKP1 family. (163 aa)
ANAPC1ANAPC1 isoform 2. (1944 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
BUB1BUB1 isoform 1. (1091 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (716 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CPEB1CPEB1 isoform 5. (626 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
CDC27Cell division cycle 27 homolog. (832 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
REC8Meiotic recombination protein REC8-like 1. (547 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PTTG2PTTG2 isoform 1. (196 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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