STRINGSTRING
FBXO2 FBXO2 FBXO6 FBXO6 HSPA5 HSPA5 UBQLN4 UBQLN4 ATF6 ATF6 DNAJC1 DNAJC1 UBE2D1 UBE2D1 SAR1A SAR1A SEC24C SEC24C SEC31B SEC31B GANAB GANAB UBXN1 UBXN1 CRYAB CRYAB HYOU1 HYOU1 CKAP4 CKAP4 ERP29 ERP29 HSPH1 HSPH1 DNAJC3 DNAJC3 UGGT2 UGGT2 DAD1 DAD1 SEC23A SEC23A EIF2S1 EIF2S1 SEL1L SEL1L EIF2AK4 EIF2AK4 DNAJA2 DNAJA2 MBTPS1 MBTPS1 P4HB P4HB LMAN1 LMAN1 UBXN6 UBXN6 PRKCSH PRKCSH CALR CALR RAD23A RAD23A DNAJB1 DNAJB1 HSPBP1 HSPBP1 UBXN2A UBXN2A PREB PREB DNAJC5G DNAJC5G MOGS MOGS EIF2AK3 EIF2AK3 UGGT1 UGGT1 EDEM2 EDEM2 UBE2G2 UBE2G2 ATF4 ATF4 RBX1 RBX1 EDEM1 EDEM1 NGLY1 NGLY1 RPN1 RPN1 SEC24B SEC24B SAR1B SAR1B UBE2D2 UBE2D2 LMAN2 LMAN2 CANX CANX MAPK9 MAPK9 HSP90AB1 HSP90AB1 BAG2 BAG2 SEC63 SEC63 MAN1A1 MAN1A1 PRKN PRKN EIF2AK1 EIF2AK1 SEC61G SEC61G CUL1 CUL1 PDIA4 PDIA4 DNAJC5B DNAJC5B TRAM1 TRAM1 PLAA PLAA DNAJA1 DNAJA1 BAG1 BAG1 VCP VCP SEC61B SEC61B MAN1B1 MAN1B1 SVIP SVIP TXNDC5 TXNDC5 MAPK8 MAPK8 UBQLN1 UBQLN1 UBXN4 UBXN4 MAN1A2 MAN1A2 ERO1B ERO1B MAP3K5 MAP3K5 DDIT3 DDIT3 ATXN3 ATXN3 SEC62 SEC62 CASP12 CASP12 SEC24A SEC24A UBQLN3 UBQLN3 BAK1 BAK1 RNF5 RNF5 HSPA1L HSPA1L DNAJB11 DNAJB11 PDIA3 PDIA3 RPN2 RPN2 ATF6B ATF6B LMAN1L LMAN1L TUSC3 TUSC3 DDOST DDOST LOC745166 LOC745166 ENSPTRP00000060619 ENSPTRP00000060619 SELENOS SELENOS SEC61A2 SEC61A2 MARCHF6 MARCHF6 HSPA4L HSPA4L NFE2L2 NFE2L2 DNAJB2 DNAJB2 CRYAA CRYAA UFD1 UFD1 EIF2AK2 EIF2AK2 XBP1 XBP1 CAPN1 CAPN1 LOC457015 LOC457015 NPLOC4 NPLOC4 SEC61A1 SEC61A1 SKP1 SKP1 MAPK10 MAPK10 HSP90AA1 HSP90AA1 SEC13 SEC13 UBE2G1 UBE2G1 EDEM3 EDEM3 AMFR AMFR UBE2D3 UBE2D3 HSPA8 HSPA8 ERO1A ERO1A YOD1 YOD1 PDIA6 PDIA6 HSP90B1 HSP90B1 MAN1C1 MAN1C1 SSR1 SSR1 NSFL1C NSFL1C DERL2 DERL2 RAD23B RAD23B STT3B STT3B SYVN1 SYVN1 DNAJB12 DNAJB12 WFS1 WFS1 UBXN8 UBXN8 ERN1 ERN1 HSPA2 HSPA2 LOC748740 LOC748740 SSR2 SSR2 SIL1 SIL1 RNF185 RNF185 UBE2D4 UBE2D4 SEC23B SEC23B SEC24D SEC24D MBTPS2 MBTPS2 DNAJC10 DNAJC10 LOC107968084 LOC107968084 BCL2 BCL2 CAPN2 CAPN2 ERLEC1 ERLEC1 STT3A STT3A BCAP31 BCAP31 DNAJC5 DNAJC5 BAX BAX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXO2F-box protein 2. (295 aa)
FBXO6F-box only protein 6. (293 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
UBQLN4UBQLN4 isoform 1. (601 aa)
ATF6Activating transcription factor 6. (670 aa)
DNAJC1DNAJC1 isoform 2. (557 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
SEC24CSEC24 homolog C, COPII coat complex component. (1094 aa)
SEC31BLOW QUALITY PROTEIN: protein transport protein Sec31B. (1169 aa)
GANABGlucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. (966 aa)
UBXN1UBX domain protein 1. (310 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
CKAP4CKAP4 isoform 3. (597 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
HSPH1HSPH1 isoform 3. (858 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
UGGT2UGGT2 isoform 1. (1516 aa)
DAD1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
EIF2S1Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa. (315 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
DNAJA2DnaJ heat shock protein family (Hsp40) member A2. (412 aa)
MBTPS1Membrane-bound transcription factor peptidase, site 1. (1052 aa)
P4HBProtein disulfide-isomerase. (508 aa)
LMAN1Lectin, mannose-binding, 1. (510 aa)
UBXN6UBX domain protein 6. (441 aa)
PRKCSHProtein kinase C substrate 80K-H. (535 aa)
CALRCalreticulin. (414 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
HSPBP1HSPA (Heat shock 70kDa) binding protein, cytoplasmic cochaperone 1. (361 aa)
UBXN2AUBX domain protein 2A. (259 aa)
PREBProlactin regulatory element binding. (417 aa)
DNAJC5GDnaJ homolog subfamily C member 5G. (189 aa)
MOGSMannosyl-oligosaccharide glucosidase. (837 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1116 aa)
UGGT1UGGT1 isoform 5. (1568 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
UBE2G2Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa)
NGLY1NGLY1 isoform 3. (654 aa)
RPN1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (607 aa)
SEC24BSEC24B isoform 1. (1286 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
LMAN2Lectin, mannose binding 2. (325 aa)
CANXCANX isoform 1. (592 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
BAG2BCL2-associated athanogene 2. (211 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (653 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1. (630 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
CUL1CUL1 isoform 1; Belongs to the cullin family. (776 aa)
PDIA4Protein disulfide-isomerase A4. (645 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
TRAM1Translocating chain-associated membrane protein; Belongs to the TRAM family. (374 aa)
PLAAPhospholipase A2-activating protein. (795 aa)
DNAJA1DnaJ heat shock protein family (Hsp40) member A1. (397 aa)
BAG1BAG1 isoform 2. (345 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
SVIPSmall VCP/p97-interacting protein. (77 aa)
TXNDC5Thioredoxin domain-containing protein 5. (432 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
UBQLN1UBQLN1 isoform 1. (589 aa)
UBXN4UBX domain-containing protein 2. (508 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
ERO1BERO1-like protein beta. (467 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
ATXN3ATXN3 isoform 4. (374 aa)
SEC62SEC62 homolog, preprotein translocation factor. (399 aa)
CASP12CASP12 isoform 1; Belongs to the peptidase C14A family. (341 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1093 aa)
UBQLN3UBQLN3 isoform 1. (655 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
RNF5Ring finger protein 5. (180 aa)
HSPA1LHSPA1L isoform 1; Belongs to the heat shock protein 70 family. (641 aa)
DNAJB11DnaJ heat shock protein family (Hsp40) member B11. (358 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (658 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
LMAN1LLMAN1L isoform 2. (526 aa)
TUSC3Tumor suppressor candidate 3. (348 aa)
DDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (456 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ENSPTRP00000060619LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (632 aa)
SELENOSSELENOS isoform 5. (218 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (482 aa)
MARCHF6MARCH6 isoform 1. (928 aa)
HSPA4LHeat shock protein family A (Hsp70) member 4 like. (840 aa)
NFE2L2Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (324 aa)
CRYAACRYAA isoform 1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (308 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
XBP1XBP1 isoform 4. (381 aa)
CAPN1Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. (733 aa)
LOC457015LOW QUALITY PROTEIN: endoplasmin-like. (448 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (608 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
SKP1T0093123 isoform 1; Belongs to the SKP1 family. (163 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
SEC13SEC13 isoform 7; Belongs to the WD repeat SEC13 family. (368 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (932 aa)
AMFRAutocrine motility factor receptor. (643 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
YOD1YOD1 deubiquitinase. (348 aa)
PDIA6PDIA6 isoform 2; Belongs to the protein disulfide isomerase family. (489 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
MAN1C1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa)
SSR1Signal sequence receptor subunit 1. (298 aa)
NSFL1CNSFL1 (P97) cofactor (P47). (372 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
STT3BSTT3, subunit of the oligosaccharyltransferase complex, homolog B. (826 aa)
SYVN1Synovial apoptosis inhibitor 1, synoviolin. (619 aa)
DNAJB12DnaJ heat shock protein family (Hsp40) member B12. (409 aa)
WFS1WFS1 isoform 1. (890 aa)
UBXN8UBXN8 isoform 7. (305 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
HSPA2Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
LOC748740HSPA6 isoform 1; Belongs to the heat shock protein 70 family. (644 aa)
SSR2Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (253 aa)
SIL1SIL1 nucleotide exchange factor. (468 aa)
RNF185Ring finger protein 185. (161 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1032 aa)
MBTPS2Membrane-bound transcription factor peptidase, site 2. (527 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (822 aa)
LOC107968084Heat shock protein HSP 90-beta-like. (361 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CAPN2Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. (703 aa)
ERLEC1XTP3-transactivated gene B protein. (483 aa)
STT3ADolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A. (705 aa)
BCAP31BCAP31 isoform 3. (246 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
BAXBAX isoform 7. (123 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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