STRINGSTRING
ZFYVE9 ZFYVE9 DNAJC6 DNAJC6 ARPC5 ARPC5 ARF1 ARF1 IL2RA IL2RA STAM STAM GRK5 GRK5 HRAS HRAS AP2A2 AP2A2 TRAF6 TRAF6 ARFGAP2 ARFGAP2 GRK2 GRK2 FOLR3 FOLR3 FOLR1 FOLR1 IZUMO1R IZUMO1R CBL CBL CAPZA3 CAPZA3 RAB5B RAB5B RNF41 RNF41 KIF5A KIF5A RAB35 RAB35 GRK1 GRK1 SNX6 SNX6 EHD4 EHD4 SPG21 SPG21 SH3GL3 SH3GL3 IGF1R IGF1R VPS35 VPS35 PARD6A PARD6A CHMP1A CHMP1A ARRB2 ARRB2 PLD2 PLD2 HGS HGS PARD6G PARD6G PIP5K1C PIP5K1C SH3GL1 SH3GL1 RAB8A RAB8A EPS15L1 EPS15L1 EHD2-2 EHD2-2 STAMBP STAMBP CHMP3 CHMP3 PSD4 PSD4 CXCR1 CXCR1 IL2RB IL2RB CAV3 CAV3 RAB5A RAB5A PDCD6IP PDCD6IP CCR5 CCR5 RHOA RHOA ARF4 ARF4 CHMP2B CHMP2B CBLB CBLB SNX4 SNX4 ACAP2 ACAP2 ARAP2 ARAP2 PDGFRA PDGFRA ZFYVE16 ZFYVE16 PSD2 PSD2 ARAP3 ARAP3 FGFR4 FGFR4 SNX3 SNX3 VTA1 VTA1 CYTH3 CYTH3 WIPF3 WIPF3 ARPC1A ARPC1A ARPC1B ARPC1B CAV1 CAV1 WASL WASL ARF5 ARF5 CHMP7 CHMP7 RAB11FIP1 RAB11FIP1 ARFGEF1 ARFGEF1 CHMP4C CHMP4C WWP1 WWP1 ASAP1 ASAP1 CHMP5 CHMP5 ARPC5L ARPC5L MVB12B MVB12B GBF1 GBF1 AMPH AMPH SPART SPART PSD3 PSD3 AP2B1 AP2B1 ITCH ITCH PARD3 PARD3 PLD1 PLD1 ARRB1 ARRB1 PSD PSD DNM3 DNM3 KIF5B KIF5B TFRC TFRC IL2RG IL2RG CAPZA2 CAPZA2 SNX2 SNX2 PIP5KL1 PIP5KL1 GRK3 GRK3 WASHC4 WASHC4 HSPA1L HSPA1L LOC100610757 LOC100610757 PATR-F PATR-F PATR-G PATR-G ACAP1 ACAP1 GIT1 GIT1 ARAP1 ARAP1 LOC745166 LOC745166 ENSPTRP00000060619 ENSPTRP00000060619 CAV2 CAV2 TSG101 TSG101 SMAD2 SMAD2 CYTH4 CYTH4 LOC101057146 LOC101057146 NEDD4L NEDD4L IGF2R IGF2R FOLR2 FOLR2 IST1 IST1 VPS37C VPS37C CHMP4B CHMP4B WIPF2 WIPF2 PATR-B PATR-B CHMP2A CHMP2A MVB12A MVB12A ARFGAP3 ARFGAP3 IQSEC1 IQSEC1 GRK7 GRK7 ENSPTRP00000066786 ENSPTRP00000066786 PRKCI PRKCI VPS26B VPS26B VPS37B VPS37B ASAP3 ASAP3 RAB11B RAB11B LOC466067 LOC466067 PATR-AL PATR-AL EPN2 EPN2 AP2A1 AP2A1 SNX5 SNX5 RUFY1 RUFY1 USP8 USP8 ARF6 ARF6 EGFR EGFR PIP5K1B PIP5K1B RBSN RBSN DAB2 DAB2 CAPZB CAPZB VPS37D VPS37D WASHC5 WASHC5 SNX12 SNX12 TGFBR1 TGFBR1 SNF8 SNF8 DNM2 DNM2 RAB11FIP2 RAB11FIP2 PIP5K1A PIP5K1A RAB11FIP4 RAB11FIP4 HSPA8 HSPA8 CXCR4 CXCR4 ARPC3 ARPC3 RAB4A RAB4A EEA1 EEA1 WIPF1 WIPF1 GIT2 GIT2 STAM2 STAM2 CXCR2 CXCR2 SRC SRC AGAP2 AGAP2 CDC42 CDC42 VPS28-2 VPS28-2 SMAP2 SMAP2 ARFGEF2 ARFGEF2 RAB5C RAB5C KIF5C KIF5C HSPA2 HSPA2 ARF3 ARF3 CYTH1 CYTH1 RABEP1 RABEP1 RAB11A RAB11A IQSEC3 IQSEC3 CLTB CLTB LOC748740 LOC748740 SH3GL2 SH3GL2 SH3KBP1 SH3KBP1 VPS29 VPS29 EHD3 EHD3 ASAP2 ASAP2 DNM1 DNM1 ARPC4 ARPC4 GRK6 GRK6 CBLC CBLC PARD6B PARD6B NEDD4 NEDD4 VPS26A VPS26A SNX32 SNX32 SH3GLB2-2 SH3GLB2-2 EPN3 EPN3 WASHC3 WASHC3 ACAP3 ACAP3 RAB11FIP5 RAB11FIP5 SMURF2 SMURF2 RAB31 RAB31 AGAP1 AGAP1 AP2S1 AP2S1 FGFR3 FGFR3 VPS45 VPS45 ARPC2 ARPC2 RAB10 RAB10 VPS25 VPS25 EHD1 EHD1 VPS4A VPS4A SH3GLB1 SH3GLB1 RAB22A RAB22A SMAP1 SMAP1 SNX1 SNX1 PATR-E PATR-E CLTC CLTC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (970 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
STAMSignal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (540 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
AP2A2AP2A2 isoform 4. (380 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ARFGAP2ADP-ribosylation factor GTPase-activating protein 2. (521 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
FOLR3Folate receptor 3 (Gamma). (245 aa)
FOLR1Folate receptor alpha. (257 aa)
IZUMO1RIZUMO1 receptor, JUNO. (250 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
RAB5BRAB5B, member RAS oncogene family. (227 aa)
RNF41Ring finger protein 41. (317 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
RAB35RAB35, member RAS oncogene family. (201 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (563 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (418 aa)
EHD4EH-domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
SPG21Spastic paraplegia 21 (Autosomal recessive, Mast syndrome). (308 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
CHMP1ACHMP1A isoform 6. (112 aa)
ARRB2ARRB2 isoform 2. (430 aa)
PLD2Phospholipase. (933 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (910 aa)
EHD2-2EH-domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
STAMBPSTAM binding protein. (424 aa)
CHMP3Charged multivesicular body protein 3 isoform X1. (222 aa)
PSD4Pleckstrin and Sec7 domain containing 4. (1056 aa)
CXCR1C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. (350 aa)
IL2RBInterleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
PDCD6IPProgrammed cell death 6 interacting protein. (873 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
RHOARas homolog family member A. (193 aa)
ARF4ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
SNX4Sorting nexin 4. (450 aa)
ACAP2ArfGAP with coiled-coil, ankyrin repeat and PH domains 2. (778 aa)
ARAP2ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2. (1704 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1539 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (771 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1546 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
SNX3Sorting nexin 3. (162 aa)
VTA1Vps20-associated 1 homolog. (307 aa)
CYTH3CYTH3 isoform 1. (399 aa)
WIPF3WAS/WASL interacting protein family member 3. (483 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin related protein 2/3 complex, subunit 1A/1B. (372 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ARF5ADP-ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family. (180 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
RAB11FIP1RAB11 family interacting protein 1. (1283 aa)
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited). (1849 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
WWP1E3 ubiquitin-protein ligase. (922 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1129 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
MVB12BFamily with sequence similarity 125, member B. (307 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1859 aa)
AMPHAMPH isoform 1. (669 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
PSD3Pleckstrin and Sec7 domain containing 3. (1010 aa)
AP2B1AP complex subunit beta. (951 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
PARD3PARD3 isoform 2. (1356 aa)
PLD1Phospholipase. (1074 aa)
ARRB1ARRB1 isoform 1. (418 aa)
PSDPleckstrin and Sec7 domain containing. (1024 aa)
DNM3DNM3 isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
IL2RGIL2RG isoform 1. (369 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
SNX2Sorting nexin 2. (519 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase-like 1. (394 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
WASHC4WASH complex subunit 4. (1173 aa)
HSPA1LHSPA1L isoform 1; Belongs to the heat shock protein 70 family. (641 aa)
LOC100610757AGAP5 isoform 2. (662 aa)
PATR-FPatr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
ACAP1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (740 aa)
GIT1G protein-coupled receptor kinase interacting ArfGAP 1. (770 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1419 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ENSPTRP00000060619LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (632 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
TSG101Tumor susceptibility 101. (405 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CYTH4CYTH4 isoform 2. (397 aa)
LOC101057146Putative charged multivesicular body protein 4B-like protein CHMP4BP1. (194 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
IGF2RIGF2R isoform 2. (2491 aa)
FOLR2Folate receptor beta. (257 aa)
IST1IST1 factor associated with ESCRT-III. (376 aa)
VPS37CVacuolar protein sorting 37 homolog C. (355 aa)
CHMP4BCharged multivesicular body protein 4B. (271 aa)
WIPF2WAS/WASL interacting protein family, member 2. (440 aa)
PATR-BPatr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
MVB12AFamily with sequence similarity 125, member A. (273 aa)
ARFGAP3ADP-ribosylation factor GTPase-activating protein 3. (516 aa)
IQSEC1IQ motif and Sec7 domain 1. (1114 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
ENSPTRP00000066786LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
VPS26BVacuolar protein sorting 26 homolog B. (338 aa)
VPS37BVacuolar protein sorting 37 homolog B. (285 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (905 aa)
RAB11BRAB11B, member RAS oncogene family. (221 aa)
LOC466067WASHC2C isoform 1. (1382 aa)
PATR-ALMajor histocompatibility complex, class I, AL precursor. (365 aa)
EPN2EPN2 isoform 5. (641 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
RUFY1RUN and FYVE domain containing 1. (708 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1110 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
RBSNZinc finger, FYVE domain containing 20. (784 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
VPS37DVacuolar protein sorting 37 homolog D. (251 aa)
WASHC5WASH complex subunit 5. (1159 aa)
SNX12Sorting nexin 12. (174 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
DNM2DNM2 isoform 5; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
RAB11FIP4RAB11 family interacting protein 4. (637 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
RAB4ARAB4A, member RAS oncogene family. (224 aa)
EEA1Early endosome antigen 1. (1411 aa)
WIPF1WAS/WASL interacting protein family, member 1. (554 aa)
GIT2G protein-coupled receptor kinase interacting ArfGAP 2. (760 aa)
STAM2Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. (525 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (360 aa)
SRCTyrosine-protein kinase. (542 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
VPS28-2VPS28 isoform 16; Belongs to the VPS28 family. (267 aa)
SMAP2SMAP2 isoform 2. (429 aa)
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (Brefeldin A-inhibited). (1792 aa)
RAB5CT0136450 isoform 1. (249 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
HSPA2Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
ARF3T0093803 isoform 1; Belongs to the small GTPase superfamily. Arf family. (227 aa)
CYTH1CYTH1 isoform 3. (399 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (883 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
IQSEC3IQSEC3 isoform 1. (1187 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
LOC748740HSPA6 isoform 1; Belongs to the heat shock protein 70 family. (644 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
SH3KBP1SH3KBP1 isoform 2. (665 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (214 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (553 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (1006 aa)
DNM1DNM1 isoform 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (867 aa)
ARPC4Actin-related protein 2/3 complex subunit 4 isoform X4. (173 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (650 aa)
CBLCCbl proto-oncogene C. (474 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
VPS26AVacuolar protein sorting 26 homolog A. (334 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
SH3GLB2-2SH3 domain containing GRB2 like, endophilin B2. (404 aa)
EPN3EPN3 isoform 1. (632 aa)
WASHC3WASHC3 isoform 7. (199 aa)
ACAP3ACAP3 isoform 2. (834 aa)
RAB11FIP5RAB11FIP5 isoform 1. (1320 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
AGAP1AGAP1 isoform 5. (1151 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
VPS45VPS45 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (580 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (548 aa)
VPS4AVacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (505 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
RAB22ARAB22A, member RAS oncogene family. (194 aa)
SMAP1SMAP1 isoform 1. (471 aa)
SNX1Sorting nexin 1. (557 aa)
PATR-EPatr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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