STRINGSTRING
VAMP3 VAMP3 STX12 STX12 FCGR1A FCGR1A CTSS CTSS THBS3 THBS3 NCF2 NCF2 TUBB TUBB CK820_G0053542 CK820_G0053542 TUBAL3 TUBAL3 MRC1 MRC1 SFTPA1 SFTPA1 M6PR M6PR OLR1 OLR1 TUBA1A TUBA1A ITGA5 ITGA5 RAB5B RAB5B Pt-FCAR Pt-FCAR ATP6V0A2 ATP6V0A2 ATP6V1D ATP6V1D ATP6V0C ATP6V0C CORO1A CORO1A ITGAM ITGAM MPO MPO MRC2 MRC2 HGS HGS C3 C3 CALR CALR ATP6V1E2 ATP6V1E2 ATP6V1B1 ATP6V1B1 LOC107973630 LOC107973630 PIKFYVE PIKFYVE TUBA4A TUBA4A TUBB1 TUBB1 PEX26 PEX26 RAB5A RAB5A DYNC1LI1 DYNC1LI1 ATP6V1A ATP6V1A TLR2 TLR2 THBS4 THBS4 CANX CANX PATR-DRA PATR-DRA HLA-DQB1 HLA-DQB1 PATR-DOB PATR-DOB PATR-DMB PATR-DMB MAMU-DMA MAMU-DMA HLA-DOA HLA-DOA HLA-DPA1 HLA-DPA1 STX7 STX7 SEC61G SEC61G NCF1 NCF1 DYNC1I1 DYNC1I1 ATP6V0D2 ATP6V0D2 CTSL CTSL SEC61B SEC61B ATP6V1G1 ATP6V1G1 TLR4 TLR4 ATP6AP1 ATP6AP1 FCGR2A FCGR2A TAP1 TAP1 TFRC TFRC CYBB CYBB ATP6V0E1 ATP6V0E1 ITGAV ITGAV TUBB8 TUBB8 ITGB5 ITGB5 TUBB3 TUBB3 LOC104006793 LOC104006793 PATR-F PATR-F C1R C1R CLEC4M CLEC4M TUBB6 TUBB6 HLA-DQA1 HLA-DQA1 PATR-G PATR-G HLA-DPB1 HLA-DPB1 COMP COMP ACTB ACTB ATP6V1C1 ATP6V1C1 CD209L2 CD209L2 PATR-DQB1 PATR-DQB1 ATP6V1F-2 ATP6V1F-2 TUBB4A TUBB4A RAB7B RAB7B SEC61A2 SEC61A2 LAMP1 LAMP1 PATR-B PATR-B TUBA1B TUBA1B MBL2 MBL2 THBS1 THBS1 ENSPTRP00000066786 ENSPTRP00000066786 DYNC1I2 DYNC1I2 ITGB3 ITGB3 PATR-AL PATR-AL CD14 CD14 SEC61A1 SEC61A1 ITGB1 ITGB1 CD209 CD209 TUBA1C TUBA1C COLEC11 COLEC11 NCF4 NCF4 CD36 CD36 EEA1 EEA1 COLEC12 COLEC12 STX18 STX18 ATP6V1H ATP6V1H DYNC2H1 DYNC2H1 SFTPD SFTPD RAB5C RAB5C DYNC1H1 DYNC1H1 ATP6V0A4-2 ATP6V0A4-2 ATP6V0B ATP6V0B ATP6V1B2 ATP6V1B2 PLA2R1 PLA2R1 ITGA2 ITGA2 ATP6V1G2 ATP6V1G2 LOC738663 LOC738663 LOC745350 LOC745350 TAP2 TAP2 SFTPA2 SFTPA2 LOC750209 LOC750209 RILP RILP MARCO MARCO LAMP2 LAMP2 ATP6V1C2 ATP6V1C2 ATP6V0A1 ATP6V0A1 LOC473484 LOC473484 ITGB2 ITGB2 CYBA CYBA PIK3C3 PIK3C3 NOS1 NOS1 MSR1 MSR1 ENSPTRP00000093238 ENSPTRP00000093238 PATR-E PATR-E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAMP3Vesicle-associated membrane protein 3 (Cellubrevin). (100 aa)
STX12STX12 isoform 1; Belongs to the syntaxin family. (276 aa)
FCGR1AFCGR1A isoform 2. (373 aa)
CTSSCTSS isoform 1; Belongs to the peptidase C1 family. (331 aa)
THBS3Thrombospondin 3. (956 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (444 aa)
CK820_G0053542TUBB8 isoform 7. (435 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
MRC1Mannose receptor C-type 1. (1456 aa)
SFTPA1Surfactant protein A1. (263 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (277 aa)
OLR1Oxidized low density lipoprotein (Lectin-like) receptor 1. (273 aa)
TUBA1ADetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (451 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
RAB5BRAB5B, member RAS oncogene family. (227 aa)
Pt-FCARFCAR isoform 1. (286 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D. (247 aa)
ATP6V0CV-type H+-transporting ATPase 16kDa proteolipid subunit. (155 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
MPOMyeloperoxidase. (745 aa)
MRC2Mannose receptor, C type 2. (1479 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
C3Complement component 3. (465 aa)
CALRCalreticulin. (414 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
LOC107973630Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
PEX26Tubulin alpha-8 chain. (454 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A. (618 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
THBS4THBS4 isoform 3. (961 aa)
CANXCANX isoform 1. (592 aa)
PATR-DRAMHC class II protein; Belongs to the MHC class II family. (254 aa)
HLA-DQB1HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa)
PATR-DOBPatr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa)
PATR-DMBHLA-DMB isoform 5. (263 aa)
MAMU-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
STX7STX7 isoform 4; Belongs to the syntaxin family. (261 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CTSLCTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
FCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa)
TAP1TAP1 isoform 1. (808 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
TUBB8Tubulin beta chain-like. (424 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (797 aa)
LOC104006793HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa)
PATR-FPatr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa)
C1RComplement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (719 aa)
CLEC4MC-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (445 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (548 aa)
HLA-DQA1HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CD209L2CD209 isoform 3. (256 aa)
PATR-DQB1HLA-DRB1 isoform 1. (271 aa)
ATP6V1F-2V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (482 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (465 aa)
PATR-BPatr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (458 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (270 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSPTRP00000066786LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa)
DYNC1I2DYNC1I2 isoform 11. (650 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
PATR-ALMajor histocompatibility complex, class I, AL precursor. (365 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (384 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (256 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (519 aa)
COLEC11Collectin subfamily member 11. (271 aa)
NCF4Neutrophil cytosolic factor 4. (368 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
EEA1Early endosome antigen 1. (1411 aa)
COLEC12Collectin sub-family member 12. (759 aa)
STX18STX18 isoform 6. (336 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
DYNC2H1DYNC2H1 isoform 4. (4314 aa)
SFTPDSurfactant protein D. (375 aa)
RAB5CT0136450 isoform 1. (249 aa)
DYNC1H1Dynein, cytoplasmic 1, heavy chain 1. (4646 aa)
ATP6V0A4-2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (525 aa)
PLA2R1PLA2R1 isoform 2. (1466 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
ATP6V1G2V-type proton ATPase subunit G 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
LOC738663Tubulin beta-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Has a key role in meiotic spindle assembly and oocyte maturation (By similarity); Belongs to the tubulin family. (444 aa)
LOC745350FCGR3A isoform 2. (233 aa)
TAP2Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP). (724 aa)
SFTPA2Surfactant protein A2. (258 aa)
LOC750209Tubulin beta-8 chain isoform X2. (435 aa)
RILPRILP isoform 2. (401 aa)
MARCOMacrophage receptor with collagenous structure. (520 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
LOC473484Cathepsin L1. (276 aa)
ITGB2Integrin beta. (863 aa)
CYBACytochrome b-245 alpha chain. (210 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
MSR1MSR1 isoform 3. (460 aa)
ENSPTRP00000093238Tubulin beta-8 chain-like. (439 aa)
PATR-EPatr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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