STRINGSTRING
MTOR MTOR SESN2 SESN2 RRAGC RRAGC PRKAA2 PRKAA2 LAMTOR5 LAMTOR5 NRAS NRAS WNT9A WNT9A DDIT4 DDIT4 HRAS HRAS RPS6KB2 RPS6KB2 LAMTOR1 LAMTOR1 WNT11 WNT11 FZD4 FZD4 WNT5B WNT5B LRP6 LRP6 WNT10B WNT10B WNT1 WNT1 FZD10 FZD10 CAB39L CAB39L ATP6V1D ATP6V1D IGF1R IGF1R TELO2 TELO2 PRKCB PRKCB SLC7A5 SLC7A5 DVL2 DVL2 FZD2 FZD2 WNT3 WNT3 RPS6KB1 RPS6KB1 PRKCA PRKCA GRB2 GRB2 RPTOR RPTOR LPIN2 LPIN2 SEH1L SEH1L STK11 STK11 MAP2K2 MAP2K2 PIK3R2 PIK3R2 AKT1S1 AKT1S1 PRKCG PRKCG ATP6V1E2 ATP6V1E2 ATP6V1B1 ATP6V1B1 FZD5 FZD5 WNT10A WNT10A IRS1 IRS1 CAB39 CAB39 TTI1 TTI1 MAPK1 MAPK1 PRR5 PRR5 RHOA RHOA NPRL2 NPRL2 ATP6V1A ATP6V1A PIK3CB PIK3CB DVL3 DVL3 LAMTOR3 LAMTOR3 SKP2 SKP2 CASTOR2 CASTOR2 WNT2 WNT2 WNT16 WNT16 FZD3 FZD3 IKBKB IKBKB DEPTOR DEPTOR RRAGA RRAGA ATP6V1G1 ATP6V1G1 MAPKAP1 MAPKAP1 FZD6 FZD6 SOS2 SOS2 EIF4E1B EIF4E1B FZD9 FZD9 PRKAA1 PRKAA1 WNT3A WNT3A SOS1 SOS1 MAPK3 MAPK3 WNT2B WNT2B ATP6V1C1 ATP6V1C1 GRB10 GRB10 WNT9B WNT9B ATP6V1F-2 ATP6V1F-2 RPS6 RPS6 LAMTOR4 LAMTOR4 MIOS MIOS STRADB STRADB MAP2K1 MAP2K1 INSR INSR RPS6KA2 RPS6KA2 WNT4 WNT4 SLC38A9 SLC38A9 TSC1 TSC1 WNT7B WNT7B PIK3R3 PIK3R3 WNT7A WNT7A FNIP1 FNIP1 TNFRSF1A TNFRSF1A IGF1 IGF1 LRP5 LRP5 EIF4E EIF4E MLST8 MLST8 SLC3A2 SLC3A2 SEC13 SEC13 RPS6KA6 RPS6KA6 LPIN1 LPIN1 FLCN FLCN RICTOR RICTOR PIK3R1 PIK3R1 CLIP1 CLIP1 ATP6V1H ATP6V1H NPRL3 NPRL3 LPIN3 LPIN3 BRAF BRAF WNT6 WNT6 RRAGD RRAGD ATP6V1B2 ATP6V1B2 DEPDC5 DEPDC5 GSK3B GSK3B RPS6KA3 RPS6KA3 TBC1D7 TBC1D7 AKT1 AKT1 FNIP2 FNIP2 ATP6V1G2 ATP6V1G2 CHUK CHUK KRAS KRAS SGK1 SGK1 AKT3 AKT3 WNT5A WNT5A RHEB RHEB FZD1 FZD1 FZD7 FZD7 ATP6V1C2 ATP6V1C2 RNF152 RNF152 WNT8A WNT8A CASTOR1 CASTOR1 AKT2 AKT2 RPS6KA1 RPS6KA1 ULK2 ULK2 EIF4B EIF4B EIF4E2 EIF4E2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SESN2SESN2 isoform 1. (480 aa)
RRAGCRas related GTP binding C. (399 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
DDIT4DNA-damage-inducible transcript 4. (232 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CAB39LCalcium-binding protein 39-like. (337 aa)
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D. (247 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
TELO2TEL2, telomere maintenance 2, homolog. (837 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SLC7A5SLC7A5 isoform 2. (507 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
LPIN2LPIN2 isoform 2. (896 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
AKT1S1AKT1 substrate 1 (Proline-rich). (276 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
CAB39Calcium binding protein 39. (341 aa)
TTI1TTI1 isoform 1. (1089 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PRR5Proline-rich protein 5 isoform X2. (411 aa)
RHOARas homolog family member A. (193 aa)
NPRL2Nitrogen permease regulator-like 2. (380 aa)
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A. (618 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
SKP2S-phase kinase-associated protein 2 (P45). (425 aa)
CASTOR2GATS protein-like 2. (329 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (409 aa)
RRAGARas-related GTP binding A. (341 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MAPKAP1Mitogen-activated protein kinase associated protein 1. (522 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
GRB10Growth factor receptor-bound protein 10. (594 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
ATP6V1F-2V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (137 aa)
MIOSMissing oocyte, meiosis regulator, homolog. (875 aa)
STRADBSTE20-related kinase adaptor beta. (419 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
RPS6KA2Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SLC38A9Solute carrier family 38, member 9. (561 aa)
TSC1TSC complex subunit 1. (1164 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1166 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
MLST8MLST8 isoform 3. (327 aa)
SLC3A2Solute carrier family 3 member 2. (631 aa)
SEC13SEC13 isoform 7; Belongs to the WD repeat SEC13 family. (368 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
LPIN1LPIN1 isoform 7. (975 aa)
FLCNT0180863 isoform 1. (579 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CLIP1CAP-Gly domain containing linker protein 1. (1433 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
NPRL3Nitrogen permease regulator-like 3. (556 aa)
LPIN3LPIN3 isoform 2. (856 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RRAGDRas-related GTP binding D. (400 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (525 aa)
DEPDC5DEP domain containing 5. (1605 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
TBC1D7TBC1 domain family, member 7. (293 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
FNIP2Folliculin interacting protein 2. (1167 aa)
ATP6V1G2V-type proton ATPase subunit G 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RHEBRHEB isoform 1. (184 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
RNF152Ring finger protein 152. (203 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1 isoform X2. (351 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ULK2Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1036 aa)
EIF4BEukaryotic translation initiation factor 4B. (615 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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