STRINGSTRING
MTOR MTOR PRKAA2 PRKAA2 CREB3L4 CREB3L4 ADIPOR1 ADIPOR1 PFKFB2 PFKFB2 PFKP PFKP SIRT1 SIRT1 SCD SCD PPP2R2D PPP2R2D CREB3L1 CREB3L1 PPP2R5B PPP2R5B RPS6KB2 RPS6KB2 PPP2R1B PPP2R1B GYS2 GYS2 PRKAB1 PRKAB1 CAMKK2 CAMKK2 FOXO1 FOXO1 CAB39L CAB39L IRS2 IRS2 PCK2 PCK2 PPP2R3C PPP2R3C PPP2R5C PPP2R5C IGF1R IGF1R MLYCD MLYCD SLC2A4 SLC2A4 G6PC3 G6PC3 RPS6KB1 RPS6KB1 RPTOR RPTOR FASN FASN STK11 STK11 EEF2 EEF2 CREB3L3 CREB3L3 RAB8A RAB8A PIK3R2 PIK3R2 LIPE LIPE AKT1S1 AKT1S1 G6PC2 G6PC2 PRKAG3 PRKAG3 IRS1 IRS1 CAB39 CAB39 PCK1 PCK1 PFKFB4 PFKFB4 PPP2R3A PPP2R3A PIK3CB PIK3CB ADIPOQ ADIPOQ PPARGC1A PPARGC1A TBC1D1 TBC1D1 SCD5 SCD5 CCNA2 CCNA2 PPP2R5D PPP2R5D CFTR CFTR CREB3L2 CREB3L2 FBP2 FBP2 FBP1 FBP1 RAB14 RAB14 PFKL PFKL GYS1 GYS1 ADIPOR2 ADIPOR2 CPT1B CPT1B CPT1C CPT1C PRKAA1 PRKAA1 CREB3 CREB3 FOXO3 FOXO3 PFKM PFKM RAB2A RAB2A MAP3K7 MAP3K7 LEPR LEPR PFKFB3 PFKFB3 STRADB STRADB INSR INSR PPP2CA PPP2CA TSC1 TSC1 PIK3R3 PIK3R3 LOC100609914 LOC100609914 RAB11B RAB11B IGF1 IGF1 PPP2R2A PPP2R2A CCNA1 CCNA1 CPT1A CPT1A LEP LEP CREB1 CREB1 ACACA ACACA CD36 CD36 G6PC G6PC SREBF1 SREBF1 PPARG PPARG HMGCR HMGCR PIK3R1 PIK3R1 CREB5 CREB5 PRKAG2-2 PRKAG2-2 PRKAB2 PRKAB2 PPP2R2B PPP2R2B PPP2R5A PPP2R5A ACACB ACACB IRS4 IRS4 PFKFB1 PFKFB1 AKT1 AKT1 PPP2R1A PPP2R1A ADRA1A ADRA1A AKT3 AKT3 CCND1 CCND1 HNF4A HNF4A RHEB RHEB PPP2CB PPP2CB EEF2K EEF2K AKT2 AKT2 RAB10 RAB10 PPP2R2C PPP2R2C PRKAG1 PRKAG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2. (522 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (862 aa)
SIRT1SIRT1 isoform 2. (751 aa)
SCDStearoyl-CoA desaturase (Delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. (359 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
FOXO1FOXO1 isoform 1. (655 aa)
CAB39LCalcium-binding protein 39-like. (337 aa)
IRS2IRS2 isoform 1. (1340 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
PPP2R3CProtein phosphatase 2, regulatory subunit B'', gamma. (453 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
MLYCDMalonyl-CoA decarboxylase, mitochondrial. (493 aa)
SLC2A4SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
FASNFatty acid synthase. (2511 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
LIPELIPE isoform 1. (1076 aa)
AKT1S1AKT1 substrate 1 (Proline-rich). (276 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
CAB39Calcium binding protein 39. (341 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4. (469 aa)
PPP2R3APPP2R3A isoform 1. (1150 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
TBC1D1TBC1 (Tre-2/USP6, BUB2, cdc16) domain family, member 1. (1168 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
CPT1BCPT1B isoform 2; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
FOXO3FOXO3 isoform 1. (673 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
RAB2ARAB2A, member RAS oncogene family. (212 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LEPRLeptin receptor. (1165 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (650 aa)
STRADBSTE20-related kinase adaptor beta. (419 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
TSC1TSC complex subunit 1. (1164 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
LOC100609914PPP2R3B isoform 3. (475 aa)
RAB11BRAB11B, member RAS oncogene family. (221 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CCNA1CCNA1 isoform 3; Belongs to the cyclin family. (421 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CREB5CREB5 isoform 1. (508 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
ACACBACACB isoform 2. (2458 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
RHEBRHEB isoform 1. (184 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (469 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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