STRINGSTRING
MTOR MTOR SESN2 SESN2 PRKAA2 PRKAA2 NRAS NRAS CREB3L4 CREB3L4 ADIPOR1 ADIPOR1 SIRT1 SIRT1 HRAS HRAS CAT CAT CREB3L1 CREB3L1 RPS6KB2 RPS6KB2 ATG101 ATG101 PRKAB1 PRKAB1 CAMKK2 CAMKK2 KL KL FOXO1 FOXO1 IRS2 IRS2 ADCY4 ADCY4 IGF1R IGF1R ADCY9 ADCY9 TP53 TP53 RPS6KB1 RPS6KB1 RPTOR RPTOR STK11 STK11 CREB3L3 CREB3L3 PRKACA PRKACA PIK3R2 PIK3R2 AKT1S1 AKT1S1 ADCY3 ADCY3 PRKAG3 PRKAG3 IRS1 IRS1 ATF4 ATF4 APPL1 APPL1 ADCY5 ADCY5 PIK3CB PIK3CB ADIPOQ ADIPOQ PPARGC1A PPARGC1A NFKB1 NFKB1 ATG5 ATG5 SESN1 SESN1 ADCY1 ADCY1 CREB3L2 CREB3L2 RB1CC1 RB1CC1 PRKACG PRKACG PRKACB PRKACB ADIPOR2 ADIPOR2 EIF4E1B EIF4E1B PRKAA1 PRKAA1 CREB3 CREB3 FOXO3 FOXO3 EHMT2 EHMT2 RELA RELA ATF6B ATF6B ADCY7 ADCY7 INSR INSR TSC1 TSC1 ATF2 ATF2 PIK3R3 PIK3R3 IGF1 IGF1 EIF4E EIF4E CREB1 CREB1 SESN3 SESN3 PPARG PPARG PIK3R1 PIK3R1 ADCY8 ADCY8 CREB5 CREB5 PRKAG2-2 PRKAG2-2 PRKAB2 PRKAB2 IRS4 IRS4 AKT1 AKT1 SOD2 SOD2 ADCY2 ADCY2 KRAS KRAS AKT3 AKT3 RHEB RHEB AKT2 AKT2 BAX BAX EIF4E2 EIF4E2 PRKAG1 PRKAG1 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SESN2SESN2 isoform 1. (480 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
SIRT1SIRT1 isoform 2. (751 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
ATG101Chromosome 12 open reading frame 44. (218 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
KLKL isoform 1. (1012 aa)
FOXO1FOXO1 isoform 1. (655 aa)
IRS2IRS2 isoform 1. (1340 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
AKT1S1AKT1 substrate 1 (Proline-rich). (276 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
APPL1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (709 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SESN1SESN1 isoform 1. (551 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
RB1CC1RB1-inducible coiled-coil 1. (1594 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
FOXO3FOXO3 isoform 1. (673 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
TSC1TSC complex subunit 1. (1164 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SESN3SESN3 isoform 5. (492 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CREB5CREB5 isoform 1. (508 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RHEBRHEB isoform 1. (184 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BAXBAX isoform 7. (123 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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