STRINGSTRING
MTOR MTOR PRKAA2 PRKAA2 NRAS NRAS SIRT1 SIRT1 EIF4EBP2 EIF4EBP2 HRAS HRAS CAT CAT RPS6KB2 RPS6KB2 CRYAB CRYAB PRKAB1 PRKAB1 FOXO1 FOXO1 IRS2 IRS2 ADCY4 ADCY4 IGF1R IGF1R ADCY9 ADCY9 RPS6KB1 RPS6KB1 RPTOR RPTOR PRKACA PRKACA PIK3R2 PIK3R2 AKT1S1 AKT1S1 ADCY3 ADCY3 PRKAG3 PRKAG3 IRS1 IRS1 SOD1 SOD1 ADCY5 ADCY5 PIK3CB PIK3CB ATG5 ATG5 ADCY1 ADCY1 PRKACG PRKACG PRKACB PRKACB PRKAA1 PRKAA1 HDAC2 HDAC2 FOXO3 FOXO3 HSPA1L HSPA1L LOC745166 LOC745166 ENSPTRP00000060619 ENSPTRP00000060619 ADCY7 ADCY7 INSR INSR PIK3R3 PIK3R3 IGF1 IGF1 HSPA8 HSPA8 HDAC1 HDAC1 PIK3R1 PIK3R1 ADCY8 ADCY8 PRKAG2-2 PRKAG2-2 PRKAB2 PRKAB2 IRS4 IRS4 CLPB CLPB HSPA2 HSPA2 LOC748740 LOC748740 AKT1 AKT1 SOD2 SOD2 ADCY2 ADCY2 KRAS KRAS AKT3 AKT3 AKT2 AKT2 FOXA2 FOXA2 PRKAG1 PRKAG1 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
SIRT1SIRT1 isoform 2. (751 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
FOXO1FOXO1 isoform 1. (655 aa)
IRS2IRS2 isoform 1. (1340 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
AKT1S1AKT1 substrate 1 (Proline-rich). (276 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
FOXO3FOXO3 isoform 1. (673 aa)
HSPA1LHSPA1L isoform 1; Belongs to the heat shock protein 70 family. (641 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ENSPTRP00000060619LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (632 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
CLPBCLPB isoform 2. (705 aa)
HSPA2Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
LOC748740HSPA6 isoform 1; Belongs to the heat shock protein 70 family. (644 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOXA2FOXA2 isoform 1. (464 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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