(33 nodes) Apoptosis - multiple species network (Pan troglodytes)

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	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	SEPTIN4	C17orf47 isoform 1. (1012 aa)
	CASP8	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
	BCL2L1	BCL2L1 isoform 6. (233 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	BECN1	Beclin 1, autophagy related. (450 aa)
	BAK1	BCL2-antagonist/killer 1. (211 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	LOC100614689	BCL2-related ovarian killer. (207 aa)
	LOC107972317	Cytochrome c-like. (102 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily, member 1A. (455 aa)
	BECN2	BECN2 isoform 1. (431 aa)
	MAPK10	Mitogen-activated protein kinase. (551 aa)
	DIABLO	Diablo, IAP-binding mitochondrial protein. (239 aa)
	XIAP	Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (497 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	CASP7	CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	PMAIP1	PMAIP1 isoform 2. (134 aa)
	LOC104002760	Cytochrome c. (110 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (298 aa)
	BIRC6	BIRC6 isoform 5. (4904 aa)
	CASP9	CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (610 aa)
	BAX	BAX isoform 7. (123 aa)
	LOC742456	Cytochrome c-like. (105 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSPTRP00000042795	ENSPTRP00000050271	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2-antagonist/killer 1.	0.642
APAF1	BAX	ENSPTRP00000042795	ENSPTRP00000092787	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BAX isoform 7.	0.626
APAF1	BCL2	ENSPTRP00000042795	ENSPTRP00000090293	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.953
APAF1	BCL2L1	ENSPTRP00000042795	ENSPTRP00000022903	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2L1 isoform 6.	0.895
APAF1	BCL2L11	ENSPTRP00000042795	ENSPTRP00000076253	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.690
APAF1	BID	ENSPTRP00000042795	ENSPTRP00000024179	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.513
APAF1	BIRC2	ENSPTRP00000042795	ENSPTRP00000007251	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.786
APAF1	BIRC3	ENSPTRP00000042795	ENSPTRP00000090891	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 3.	0.744
APAF1	BIRC6	ENSPTRP00000042795	ENSPTRP00000086416	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BIRC6 isoform 5.	0.878
APAF1	BIRC7	ENSPTRP00000042795	ENSPTRP00000082638	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.707
APAF1	CASP3	ENSPTRP00000042795	ENSPTRP00000054330	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.997
APAF1	CASP7	ENSPTRP00000042795	ENSPTRP00000074501	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.908
APAF1	CASP8	ENSPTRP00000042795	ENSPTRP00000021879	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.914
APAF1	CASP9	ENSPTRP00000042795	ENSPTRP00000089496	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSPTRP00000042795	ENSPTRP00000032465	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.999
APAF1	DIABLO	ENSPTRP00000042795	ENSPTRP00000071257	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo, IAP-binding mitochondrial protein.	0.904
APAF1	FADD	ENSPTRP00000042795	ENSPTRP00000006883	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.670
APAF1	HTRA2	ENSPTRP00000042795	ENSPTRP00000073790	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HtrA serine peptidase 2.	0.694
APAF1	LOC100614689	ENSPTRP00000042795	ENSPTRP00000059900	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2-related ovarian killer.	0.653
APAF1	LOC104002760	ENSPTRP00000042795	ENSPTRP00000082320	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c.	0.994