STRINGSTRING
GCLM GCLM LPCAT3 LPCAT3 MAP1LC3B MAP1LC3B ALOX15 ALOX15 TP53 TP53 PCBP1 PCBP1 STEAP3 STEAP3 SLC40A1 SLC40A1 ACSL3 ACSL3 MAP1LC3A MAP1LC3A GSS GSS HMOX1 HMOX1 TF TF CP CP ACSL1 ACSL1 FTMT FTMT NCOA4 NCOA4 GCLC GCLC ATG5 ATG5 SAT1-2 SAT1-2 FTHL17 FTHL17 ACSL4 ACSL4 MAP1LC3C MAP1LC3C ACSL5 ACSL5 SLC39A8 SLC39A8 TFRC TFRC CYBB CYBB GPX4 GPX4 FTL FTL SLC39A14 SLC39A14 PCBP2 PCBP2 SLC7A11 SLC7A11 SLC3A2 SLC3A2 SLC11A2 SLC11A2 VDAC3 VDAC3 PRNP PRNP ATG7 ATG7 VDAC2 VDAC2 FTH1 FTH1 ACSL6 ACSL6 ENSPTRP00000088677 ENSPTRP00000088677
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCLMGlutamate-cysteine ligase, modifier subunit. (274 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
MAP1LC3BMicrotubule-associated proteins 1A/1B light chain 3B. (125 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PCBP1Poly(rC) binding protein 1. (356 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
ACSL3Acyl-CoA synthetase long-chain family member 3. (720 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
GSSGlutathione synthetase. (474 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
TFSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
CPCP isoform 1; Belongs to the multicopper oxidase family. (1069 aa)
ACSL1ACSL1 isoform 9. (698 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (242 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
GCLCGlutamate-cysteine ligase, catalytic subunit. (637 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SAT1-2Spermidine/spermine N1-acetyltransferase 1. (171 aa)
FTHL17Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ACSL4Acyl-CoA synthetase long-chain family member 4. (749 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (147 aa)
ACSL5Acyl-CoA synthetase long-chain family member 5. (739 aa)
SLC39A8Solute carrier family 39 (Zinc transporter), member 8. (460 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
SLC39A14SLC39A14 isoform 1. (490 aa)
PCBP2Poly(rC) binding protein 2. (366 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
SLC3A2Solute carrier family 3 member 2. (631 aa)
SLC11A2SLC11A2 isoform 1. (590 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
VDAC2VDAC2 isoform 1. (260 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ACSL6T0093412 isoform 1. (722 aa)
ENSPTRP00000088677Microtubule-associated proteins 1A/1B light chain 3B. (126 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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