STRINGSTRING
CTBP2 CTBP2 DTX4 DTX4 MAML2 MAML2 DTX3 DTX3 DTX1 DTX1 PSEN1 PSEN1 DVL2 DVL2 KAT2A KAT2A NOTCH3 NOTCH3 PSENEN PSENEN JAG1 JAG1 RBPJL RBPJL EP300 EP300 KAT2B KAT2B DTX3L DTX3L DVL3 DVL3 HEY2 HEY2 DLL1 DLL1 NOTCH1 NOTCH1 APH1A APH1A NUMB NUMB HDAC2 HDAC2 ADAM17 ADAM17 MAML1 MAML1 ATXN1 ATXN1 NOTCH4 NOTCH4 ATXN1L ATXN1L DLL3 DLL3 NUMBL NUMBL HES1 HES1 SNW1 SNW1 HEY1 HEY1 MFNG MFNG CREBBP CREBBP NOTCH2 NOTCH2 HDAC1 HDAC1 CTBP1 CTBP1 RBPJ RBPJ MAML3 MAML3 LFNG LFNG NCOR2 NCOR2 HEYL HEYL NCSTN NCSTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTBP2CTBP2 isoform 10. (985 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
DTX3Deltex E3 ubiquitin ligase 3. (347 aa)
DTX1Deltex E3 ubiquitin ligase 1. (620 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
PSENENT0105581 isoform 1. (101 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
EP300E1A binding protein p300. (2175 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
ADAM17ADAM17 isoform 3. (999 aa)
MAML1MAML1 isoform 1. (1016 aa)
ATXN1ATXN1 isoform 2. (827 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
ATXN1LATXN1L isoform 2. (689 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
NUMBLNUMBL isoform 1. (611 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SNW1SNW domain containing 1. (571 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. (321 aa)
CREBBPCREB binding protein. (2442 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MAML3MAML3 isoform 1. (1134 aa)
LFNGLFNG isoform 5. (405 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
NCSTNNCSTN isoform 1. (721 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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