STRINGSTRING
EPHA2 EPHA2 EPHA8 EPHA8 GNAI3 GNAI3 NRAS NRAS SEMA6C SEMA6C EFNA4 EFNA4 EFNA3 EFNA3 EFNA1 EFNA1 PLXNA2 PLXNA2 NRP1 NRP1 HRAS HRAS LRRC4C LRRC4C PAK1 PAK1 TRPC6 TRPC6 ROBO3 ROBO3 WNT5B WNT5B RND1 RND1 NTN4 NTN4 EFNB2 EFNB2 CFL2 CFL2 PAK6 PAK6 NEO1 NEO1 SEMA7A SEMA7A SEMA4B SEMA4B NTN3 NTN3 PARD6A PARD6A NTN1 NTN1 SSH2 SSH2 PRKCA PRKCA MYL12B MYL12B PARD6G PARD6G SEMA6B SEMA6B PIK3R2 PIK3R2 RRAS RRAS GDF7 GDF7 SEMA4C SEMA4C NCK2 NCK2 NGEF NGEF PAK5 PAK5 MYL9 MYL9 PLCG1 PLCG1 BMP7 BMP7 MAPK1 MAPK1 PLXNB1 PLXNB1 RHOA RHOA GNAI2 GNAI2 SEMA3G SEMA3G EPHA3 EPHA3 EPHA6 EPHA6 SEMA5B SEMA5B RYK RYK NCK1 NCK1 PIK3CB PIK3CB EPHA5 EPHA5 BMPR1B BMPR1B UNC5C UNC5C SEMA5A SEMA5A RASA1 RASA1 ABLIM3 ABLIM3 EPHA7 EPHA7 SEMA3C SEMA3C SEMA3A SEMA3A SEMA3D SEMA3D EPHB4 EPHB4 LRRC4 LRRC4 SMO SMO EPHB6 EPHB6 EPHA1 EPHA1 FZD3 FZD3 TRPC5 TRPC5 PLXNA3 PLXNA3 PARD3 PARD3 SRGAP1 SRGAP1 SEMA4F SEMA4F TRPC4 TRPC4 SRGAP3 SRGAP3 NFATC2 NFATC2 EFNA2 EFNA2 SEMA4D SEMA4D LIMK2 LIMK2 SRGAP2 SRGAP2 DPYSL5 DPYSL5 EPHB2 EPHB2 UNC5D UNC5D TRPC3 TRPC3 MAPK3 MAPK3 EPHB1 EPHB1 ARHGEF12 ARHGEF12 PLXNA4 PLXNA4 PTPN11 PTPN11 RGMA RGMA PAK3 PAK3 WNT4 WNT4 ROCK2 ROCK2 PIK3R3 PIK3R3 MYL12A MYL12A PPP3CB PPP3CB PDK1 PDK1 SEMA3E SEMA3E ILK ILK SEMA6A SEMA6A PPP3CA PPP3CA RHOD-2 RHOD-2 CXCL12 CXCL12 DCC DCC SEMA4A SEMA4A DPYSL2 DPYSL2 ITGB1 ITGB1 GNAI1 GNAI1 ABL1 ABL1 EPHB3 EPHB3 CAMK2B CAMK2B UNC5A UNC5A PPP3CC PPP3CC ROBO1 ROBO1 ABLIM2 ABLIM2 CXCR4 CXCR4 SHH SHH PLXNC1 PLXNC1 PLCG2 PLCG2 SEMA4G SEMA4G SRC SRC PIK3R1 PIK3R1 PLXNB2 PLXNB2 FYN FYN CDC42 CDC42 LIMK1-2 LIMK1-2 SSH3 SSH3 SLIT2 SLIT2 SEMA3F SEMA3F CAMK2A CAMK2A L1CAM L1CAM GSK3B GSK3B MET MET SLIT1 SLIT1 TRPC1 TRPC1 KRAS KRAS ROCK1 ROCK1 PARD6B PARD6B EPHA4 EPHA4 WNT5A WNT5A SEMA3B SEMA3B CFL1 CFL1 NFATC3 NFATC3 PTCH1 PTCH1 EFNB3 EFNB3 PLXNA1 PLXNA1 NFATC4 NFATC4 EFNB1 EFNB1 PAK4 PAK4 SSH1 SSH1 UNC5B UNC5B BOC BOC ROBO2 ROBO2 PLXNB3 PLXNB3 MYL5 MYL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA2EPH receptor A2. (976 aa)
EPHA8EPHA8 isoform 1. (997 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
SEMA6CSEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
EFNA4EFNA4 isoform 1; Belongs to the ephrin family. (201 aa)
EFNA3Ephrin-A3 isoform X1. (238 aa)
EFNA1EFNA1 isoform 2; Belongs to the ephrin family. (205 aa)
PLXNA2PLXNA2 isoform 1. (1909 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
TRPC6Transient receptor potential cation channel, subfamily C, member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
ROBO3ROBO3 isoform 3. (1384 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
RND1RND1 isoform 1. (163 aa)
NTN4NTN4 isoform 3. (628 aa)
EFNB2EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
CFL2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
NEO1NEO1 isoform 2. (1461 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
SEMA4BSEMA4B isoform 1; Belongs to the semaphorin family. (836 aa)
NTN3NTN3 isoform 1. (580 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
NTN1NTN1 isoform 1. (604 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
MYL12BMyosin light chain 12B. (172 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
SEMA6BSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
RRASRelated RAS viral (R-ras) oncogene homolog. (218 aa)
GDF7Growth differentiation factor 7. (447 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
NCK2Cytoplasmic protein. (380 aa)
NGEFNeuronal guanine nucleotide exchange factor. (710 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MYL9Myosin, light chain 9, regulatory. (172 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLXNB1PLXNB1 isoform 1. (2135 aa)
RHOARas homolog family member A. (193 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
SEMA3GSEMA3G isoform 2; Belongs to the semaphorin family. (782 aa)
EPHA3EPH receptor A3. (983 aa)
EPHA6EPH receptor A6. (1130 aa)
SEMA5BSEMA5B isoform 1. (1352 aa)
RYKReceptor like tyrosine kinase. (610 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
EPHA5EPH receptor A5. (1038 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
ABLIM3Actin binding LIM protein family, member 3. (684 aa)
EPHA7EPHA7 isoform 2. (998 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
SEMA3DSEMA3D isoform 1; Belongs to the semaphorin family. (777 aa)
EPHB4EPH receptor B4. (987 aa)
LRRC4Leucine rich repeat containing 4. (633 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
EPHB6Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1020 aa)
EPHA1EPH receptor A1. (976 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (973 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
PARD3PARD3 isoform 2. (1356 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
SEMA4FSEMA4F isoform 1; Belongs to the semaphorin family. (770 aa)
TRPC4Transient receptor potential cation channel, subfamily C, member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
NFATC2NFATC2 isoform 4. (938 aa)
EFNA2EFNA2 isoform 1; Belongs to the ephrin family. (190 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
LIMK2LIMK2 isoform 6. (670 aa)
SRGAP2SRGAP2 isoform 1. (1071 aa)
DPYSL5DPYSL5 isoform 1. (565 aa)
EPHB2EPH receptor B2. (1055 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EPHB1EPH receptor B1. (984 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
PLXNA4PLXNA4 isoform 1. (1894 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
MYL12AMyosin light chain 12A. (177 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
ILKIntegrin-linked kinase. (533 aa)
SEMA6ASEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
RHOD-2Ras homolog family member D. (194 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
DCCDCC isoform 1. (1457 aa)
SEMA4ASEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
DPYSL2Dihydropyrimidinase-like 2. (677 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
ABLIM2ABLIM2 isoform 7. (649 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PLXNC1PLXNC1 isoform 1. (1568 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SEMA4GSEMA4G isoform 3; Belongs to the semaphorin family. (843 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
PLXNB2PLXNB2 isoform 1. (1838 aa)
FYNTyrosine-protein kinase. (537 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
SSH3Slingshot protein phosphatase 3. (658 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
SEMA3FSEMA3F isoform 2; Belongs to the semaphorin family. (785 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
EPHA4EPH receptor A4. (986 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SEMA3BSEMA3B isoform 2; Belongs to the semaphorin family. (749 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
EFNB1EFNB1 isoform 1; Belongs to the ephrin family. (346 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
SSH1Slingshot homolog 1. (1062 aa)
UNC5BUNC5B isoform 2. (945 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1115 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
PLXNB3PLXNB3 isoform 1. (1932 aa)
MYL5Myosin light chain 5. (173 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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