STRINGSTRING
BMP8B BMP8B PATJ PATJ TGFB2 TGFB2 WNT9A WNT9A CTNNA3 CTNNA3 DLG5 DLG5 BMPR1A BMPR1A PPP2R2D PPP2R2D WNT11 WNT11 FZD4 FZD4 YAP1 YAP1 BIRC2 BIRC2 PPP2R1B PPP2R1B WNT5B WNT5B TEAD4 TEAD4 CCND2 CCND2 WNT10B WNT10B WNT1 WNT1 FZD10 FZD10 LATS2 LATS2 SAV1 SAV1 BMP4 BMP4 MPP5 MPP5 TGFB3 TGFB3 PARD6A PARD6A CDH1 CDH1 YWHAE YWHAE DLG4 DLG4 DVL2 DVL2 FZD2 FZD2 WNT3 WNT3 AXIN2 AXIN2 SMAD7 SMAD7 SMAD4 SMAD4 PARD6G PARD6G AMH AMH WTIP WTIP TGFB1 TGFB1 ID2 ID2 YWHAQ YWHAQ GDF7 GDF7 FZD5 FZD5 WNT10A WNT10A BMP2 BMP2 GDF5 GDF5 BMP7 BMP7 YWHAH YWHAH LIMD1 LIMD1 DVL3 DVL3 AFP AFP BMPR1B BMPR1B SMAD1 SMAD1 APC APC CTNNA1 CTNNA1 FGF1 FGF1 WWC1 WWC1 BMP6 BMP6 BMP5 BMP5 LATS1 LATS1 YWHAG YWHAG SERPINE1 SERPINE1 WNT2 WNT2 WNT16 WNT16 FZD3 FZD3 SNAI2 SNAI2 AMOT AMOT GLI2 GLI2 CRB2 CRB2 PARD3 PARD3 RASSF1 RASSF1 FZD6 FZD6 CTNNB1 CTNNB1 WWTR1 WWTR1 CRB1 CRB1 SOX2 SOX2 FZD9 FZD9 WNT3A WNT3A YWHAB YWHAB AJUBA AJUBA NKD1 NKD1 WNT2B WNT2B GYPE1 GYPE1 MOB1B MOB1B ACTB ACTB ID1 ID1 WNT9B WNT9B AREG AREG LLGL2 LLGL2 SMAD2 SMAD2 WNT4 WNT4 PPP2CA PPP2CA WNT7B WNT7B TP73 TP73 WNT7A WNT7A CSNK1D CSNK1D DLG1 DLG1 PRKCI PRKCI FRMD6 FRMD6 PPP2R2A PPP2R2A ENSPTRP00000068204 ENSPTRP00000068204 PPP1CB PPP1CB NKD2 NKD2 CCND3 CCND3 DLG3 DLG3 MOB1A MOB1A NF2 NF2 TGFBR1 TGFBR1 YWHAZ YWHAZ MYC MYC CTNNA2 CTNNA2 GDF6 GDF6 BTRC BTRC PPP1CC PPP1CC TP53BP2 TP53BP2 PPP2R2B PPP2R2B WNT6 WNT6 LEF1 LEF1 STK3 STK3 TCF7 TCF7 GSK3B GSK3B TEAD3 TEAD3 PPP2R1A PPP2R1A TEAD2 TEAD2 PARD6B PARD6B CCND1 CCND1 WNT5A WNT5A FZD1 FZD1 PPP2CB PPP2CB APC2 APC2 FZD7 FZD7 WNT8A WNT8A CCN2 CCN2 CSNK1E CSNK1E BIRC3 BIRC3 PPP2R2C PPP2R2C ITGB2 ITGB2 DLG2 DLG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP8BBMP8B isoform 1. (402 aa)
PATJPATJ isoform 2. (1801 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
YAP1Yes-associated protein 1. (508 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
AMHAnti-Mullerian hormone. (560 aa)
WTIPWT1 interacting protein. (428 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (253 aa)
GDF7Growth differentiation factor 7. (447 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
LIMD1LIM domains containing 1. (676 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin; Belongs to the ALB/AFP/VDB family. (622 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
APCAdenomatous polyposis coli protein isoform X10. (2844 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WWC1WWC1 isoform 7. (1119 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family. (247 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
AMOTAMOT isoform 2. (1094 aa)
GLI2GLI family zinc finger 2. (1587 aa)
CRB2CRB2 isoform 1. (1285 aa)
PARD3PARD3 isoform 2. (1356 aa)
RASSF1Ras association (RalGDS/AF-6) domain family member 1. (340 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
SOX2SRY-box transcription factor 2. (319 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (538 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
GYPE1GYPA isoform 5. (121 aa)
MOB1BMOB kinase activator 1B. (221 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
AREGAREG isoform 2. (274 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1041 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
FRMD6FERM domain containing 6. (622 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
ENSPTRP0000006820414-3-3 protein homolog 1-like. (78 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (464 aa)
CCND3CCND3 isoform 1; Belongs to the cyclin family. (292 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)
MOB1AMOB1, Mps One Binder kinase activator-like 1B. (219 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
CTNNA2CTNNA2 isoform 11. (953 aa)
GDF6Growth differentiation factor 6. (455 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
TP53BP2Tumor protein p53 binding protein 2. (1137 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
STK3Serine/threonine kinase 3. (519 aa)
TCF7Transcription factor 7. (481 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
TEAD3TEA domain transcription factor 3. (435 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
APC2APC2 isoform 1. (2301 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
CCN2CTGF isoform 1. (349 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (419 aa)
BIRC3Baculoviral IAP repeat containing 3. (610 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (469 aa)
ITGB2Integrin beta. (863 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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