STRINGSTRING
ITGA10 ITGA10 THBS3 THBS3 TNN TNN TNR TNR LAMC1 LAMC1 LAMC2 LAMC2 DOCK1 DOCK1 HRAS HRAS PAK1 PAK1 BIRC2 BIRC2 CCND2 CCND2 VWF VWF ITGA5 ITGA5 ITGA7 ITGA7 FLT1 FLT1 PAK6 PAK6 SHC4 SHC4 TLN2 TLN2 IGF1R IGF1R PRKCB PRKCB MYLPF MYLPF MYLK3 MYLK3 VTN VTN ITGA3 ITGA3 COL1A1 COL1A1 CHAD CHAD PRKCA PRKCA GRB2 GRB2 MYL12B MYL12B LAMA3 LAMA3 PIP5K1C PIP5K1C VAV1 VAV1 PIK3R2 PIK3R2 PRKCG PRKCG ITGA4 ITGA4 COL4A3 COL4A3 COL6A3 COL6A3 PAK5 PAK5 MYLK2 MYLK2 MYL9 MYL9 COL9A3 COL9A3 COL6A2 COL6A2 MAPK1 MAPK1 PDGFB PDGFB PARVG PARVG CAV3 CAV3 ITGA9 ITGA9 LAMB2 LAMB2 RHOA RHOA COL6A6 COL6A6 COL6A5 COL6A5 PIK3CB PIK3CB PDGFRA PDGFRA KDR KDR IBSP IBSP EGF EGF VEGFC VEGFC ITGA1 ITGA1 THBS4 THBS4 MAPK9 MAPK9 MYLK4 MYLK4 LAMA2 LAMA2 COL1A2 COL1A2 LAMB4 LAMB4 CAV1 CAV1 ZYX ZYX TNC TNC VEGFD VEGFD ELK1 ELK1 LAMB3 LAMB3 MAPK8 MAPK8 COL2A1 COL2A1 SOS2 SOS2 CTNNB1 CTNNB1 FLT4 FLT4 CRKL CRKL PPP1R12A PPP1R12A FLNC FLNC VEGFB VEGFB COL4A4 COL4A4 ITGAV ITGAV ITGB5 ITGB5 SHC1 SHC1 SOS1 SOS1 ARHGAP5 ARHGAP5 MAPK3 MAPK3 RELN RELN COMP COMP ACTB ACTB COL4A2 COL4A2 PDGFA PDGFA CAV2 CAV2 PAK3 PAK3 MAP2K1 MAP2K1 ROCK2 ROCK2 FLNA FLNA SHC3 SHC3 PIK3R3 PIK3R3 MYL12A MYL12A COL4A5 COL4A5 THBS1 THBS1 ILK ILK IGF1 IGF1 ITGB3 ITGB3 PPP1CB PPP1CB CCND3 CCND3 LAMB1 LAMB1 EGFR EGFR ITGB1 ITGB1 ERBB2 ERBB2 MAPK10 MAPK10 COL4A6 COL4A6 PIP5K1B PIP5K1B RAP1B RAP1B TLN1 TLN1 XIAP XIAP HGF HGF PIP5K1A PIP5K1A PARVB PARVB ITGB7 ITGB7 ARHGAP35 ARHGAP35 DIAPH1 DIAPH1 COL9A2 COL9A2 SRC SRC PIK3R1 PIK3R1 MYL10-2 MYL10-2 FYN FYN CDC42 CDC42 RASGRF1 RASGRF1 PPP1CC PPP1CC PDGFD PDGFD BRAF BRAF BCAR1 BCAR1 MYL2 MYL2 PPP1R12B PPP1R12B PDGFRB PDGFRB ACTN4 ACTN4 GSK3B GSK3B ITGB4 ITGB4 ITGA2 ITGA2 ITGB8 ITGB8 AKT1 AKT1 MET MET CRK CRK VAV2 VAV2 ITGA11 ITGA11 RAP1A RAP1A ROCK1 ROCK1 LAMA1 LAMA1 ITGA8 ITGA8 AKT3 AKT3 CCND1 CCND1 CK820_G0006908 CK820_G0006908 ITGA6 ITGA6 FLNB FLNB LAMC3 LAMC3 LAMA5 LAMA5 MYLK MYLK AKT2 AKT2 PARVA PARVA PAK4 PAK4 VAV3 VAV3 BCL2 BCL2 PDGFC PDGFC BIRC3 BIRC3 CAPN2 CAPN2 VASP VASP COL4A1 COL4A1 LAMA4 LAMA4 SPP1 SPP1 MYL5 MYL5 VEGFA VEGFA PPP1R12C PPP1R12C COL9A1 COL9A1 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA10ITGA10 isoform 1; Belongs to the integrin alpha chain family. (1167 aa)
THBS3Thrombospondin 3. (956 aa)
TNNTNN isoform 1. (1299 aa)
TNRTNR isoform 1. (1358 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
LAMC2LAMC2 isoform 1. (1193 aa)
DOCK1DOCK1 isoform 1; Belongs to the DOCK family. (1854 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
VWFVon Willebrand factor. (2813 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
ITGA7ITGA7 isoform 6; Belongs to the integrin alpha chain family. (1181 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SHC4SHC adaptor protein 4. (630 aa)
TLN2TLN2 isoform 1. (2544 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
MYLK3MYLK3 isoform 1. (819 aa)
VTNVTN isoform 1. (478 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
CHADCHAD isoform 1. (359 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MYL12BMyosin light chain 12B. (172 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
COL6A3COL6A3 isoform 2. (3177 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MYLK2MYLK2 isoform 1. (596 aa)
MYL9Myosin, light chain 9, regulatory. (172 aa)
COL9A3Collagen type IX alpha 3 chain. (684 aa)
COL6A2COL6A2 isoform 4. (444 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PARVGGamma-parvin isoform X1. (331 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
RHOARas homolog family member A. (193 aa)
COL6A6Collagen, type VI, alpha 6. (2263 aa)
COL6A5COL6A5 isoform 2. (2625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
THBS4THBS4 isoform 3. (961 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
LAMB4LAMB4 isoform 2. (1761 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ZYXZYX isoform 1. (572 aa)
TNCTNC isoform 1. (2201 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
FLNCFilamin C, gamma. (2725 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
COL4A4COL4A4 isoform 1. (1690 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELNRELN isoform 3. (3460 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
FLNAFLNA isoform 8. (2711 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
MYL12AMyosin light chain 12A. (177 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
THBS1Thrombospondin 1. (1173 aa)
ILKIntegrin-linked kinase. (533 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
CCND3CCND3 isoform 1; Belongs to the cyclin family. (292 aa)
LAMB1LAMB1 isoform 5. (1789 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
TLN1TLN1 isoform 1. (2558 aa)
XIAPBaculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (497 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
PARVBBeta-parvin isoform X1. (397 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
ARHGAP35Glucocorticoid receptor DNA binding factor 1. (1519 aa)
DIAPH1DIAPH1 isoform 4. (1278 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
MYL10-2MYL10 isoform 1. (226 aa)
FYNTyrosine-protein kinase. (537 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1043 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ACTN4Actinin, alpha 4. (931 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
ITGB4Integrin beta. (1822 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1206 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CK820_G0006908TNXB isoform 2. (3702 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
FLNBFilamin B, beta. (2633 aa)
LAMC3Laminin subunit gamma 3. (1580 aa)
LAMA5Laminin, alpha 5. (2203 aa)
MYLKMYLK isoform 12. (1919 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PARVAPARVA isoform 1. (412 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
VAV3VAV3 isoform 2. (927 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
BIRC3Baculoviral IAP repeat containing 3. (610 aa)
CAPN2Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. (703 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
LAMA4LAMA4 isoform 3. (1823 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
MYL5Myosin light chain 5. (173 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (793 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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