STRINGSTRING
CLDN19 CLDN19 NEGR1 NEGR1 VCAM1 VCAM1 SELP SELP SELL SELL PTPRC PTPRC CD34 CD34 LRRC4C LRRC4C ESAM ESAM NEO1 NEO1 CD276 CD276 ITGAM ITGAM CDH5 CDH5 CDH3 CDH3 CDH1 CDH1 CDH15 CDH15 CLDN7 CLDN7 ICAM2 ICAM2 PTPRM PTPRM CD226 CD226 CD22 CD22 PVR PVR LRRC4B LRRC4B ITGA4 ITGA4 CD28 CD28 ICOS ICOS SIGLEC1 SIGLEC1 CDH4 CDH4 CLDN17 CLDN17 CLDN8 CLDN8 CLDN14 CLDN14 ITGA9 ITGA9 TIGIT TIGIT CD80 CD80 CD86 CD86 CLDN18 CLDN18 CLDN11 CLDN11 CLDN1 CLDN1 CLDN16 CLDN16 CLDN22 CLDN22 CLDN24 CLDN24 PATR-DRA PATR-DRA HLA-DQB1 HLA-DQB1 PATR-DOB PATR-DOB PATR-DMB PATR-DMB MAMU-DMA MAMU-DMA HLA-DOA HLA-DOA HLA-DPA1 HLA-DPA1 CLDN20 CLDN20 LRRC4 LRRC4 SDC2 SDC2 CD274 CD274 CD99L2 CD99L2 VSIR VSIR CD58 CD58 NLGN4X NLGN4X SDC3 SDC3 MPZ MPZ CLDN3 CLDN3 ITGAV ITGAV CD2 CD2 ITGAL ITGAL CNTNAP1 CNTNAP1 NLGN2 NLGN2 LOC104006793 LOC104006793 PATR-F PATR-F OCLN OCLN CD4 CD4 HLA-DQA1 HLA-DQA1 PATR-G PATR-G CLDN15 CLDN15 HLA-DPB1 HLA-DPB1 NLGN1 NLGN1 CADM3 CADM3 JAM2 JAM2 CD8B CD8B PATR-DQB1 PATR-DQB1 CLDN23 CLDN23 CLDN25 CLDN25 CLDN4 CLDN4 NCAM1 NCAM1 SELE SELE CNTNAP2 CNTNAP2 PATR-B PATR-B SDC1 SDC1 VTCN1 VTCN1 ENSPTRP00000066786 ENSPTRP00000066786 SPN-2 SPN-2 CD8A CD8A CD40 CD40 PATR-AL PATR-AL NCAM2 NCAM2 GLG1 GLG1 ITGB1 ITGB1 NLGN3 NLGN3 JAM3 JAM3 PTPRF PTPRF CLDN2 CLDN2 ITGB7 ITGB7 NECTIN3 NECTIN3 CNTN1 CNTN1 NRXN2 NRXN2 CD40LG CD40LG NLGN4Y NLGN4Y NECTIN1 NECTIN1 L1CAM L1CAM CTLA4 CTLA4 PDCD1 PDCD1 PECAM1 PECAM1 BV7-9 BV7-9 ITGB8 ITGB8 SDC4 SDC4 LOC751057 LOC751057 ICAM1 ICAM1 ITGA8 ITGA8 CNTN2 CNTN2 F11R F11R ITGA6 ITGA6 CLDN9 CLDN9 CLDN34 CLDN34 NECTIN2 NECTIN2 IGSF11 IGSF11 ICOSLG ICOSLG ITGB2 ITGB2 CD6 CD6 MPZL1 MPZL1 CDH2 CDH2 PATR-E PATR-E ICAM3 ICAM3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
NEGR1NEGR1 isoform 1. (354 aa)
VCAM1Vascular cell adhesion molecule 1. (650 aa)
SELPSELP isoform 2. (830 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. (385 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
CD34CD34 isoform 1. (328 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
ESAMEndothelial cell adhesion molecule. (390 aa)
NEO1NEO1 isoform 2. (1461 aa)
CD276CD276 isoform 13. (534 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
CDH3Cadherin 3, type 1, P-cadherin (Placental); Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
CDH15CDH15 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (807 aa)
CLDN7Claudin-7. (211 aa)
ICAM2Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). (275 aa)
PTPRMPTPRM isoform 4. (1465 aa)
CD226CD226 isoform 1. (336 aa)
CD22B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
PVRPVR cell adhesion molecule. (417 aa)
LRRC4BLRRC4B isoform 1. (715 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
CD28CD28 isoform 3. (220 aa)
ICOSInducible T cell costimulator. (199 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
CDH4CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
TIGITTIGIT isoform 1. (311 aa)
CD80CD80 isoform 1. (288 aa)
CD86CD86 isoform 3. (329 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (305 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PATR-DRAMHC class II protein; Belongs to the MHC class II family. (254 aa)
HLA-DQB1HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa)
PATR-DOBPatr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa)
PATR-DMBHLA-DMB isoform 5. (263 aa)
MAMU-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
LRRC4Leucine rich repeat containing 4. (633 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
CD274CD274 isoform 2. (290 aa)
CD99L2CD99 molecule-like 2. (262 aa)
VSIRChromosome 10 open reading frame 54. (311 aa)
CD58CD58 isoform 1. (250 aa)
NLGN4XNeuroligin 4 X-linked. (817 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (480 aa)
MPZMyelin protein zero. (248 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
CD2CD2 isoform 1. (351 aa)
ITGALITGAL isoform 4. (344 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
NLGN2NLGN2 isoform 1. (836 aa)
LOC104006793HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa)
PATR-FPatr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
HLA-DQA1HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
NLGN1NLGN1 isoform 1. (823 aa)
CADM3Cell adhesion molecule 3. (430 aa)
JAM2Junctional adhesion molecule 2. (312 aa)
CD8BCD8B isoform 3. (243 aa)
PATR-DQB1HLA-DRB1 isoform 1. (271 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (290 aa)
CLDN25CLDN25 isoform 1. (229 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
NCAM1Neural cell adhesion molecule 1. (884 aa)
SELESELE isoform 1. (612 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
PATR-BPatr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
ENSPTRP00000066786LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa)
SPN-2SPN isoform 1. (418 aa)
CD8ACD8A isoform 1. (235 aa)
CD40CD40 molecule, TNF receptor superfamily member 5. (277 aa)
PATR-ALMajor histocompatibility complex, class I, AL precursor. (365 aa)
NCAM2Neural cell adhesion molecule 2. (862 aa)
GLG1Golgi glycoprotein 1. (1203 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NLGN3NLGN3 isoform 5. (848 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
PTPRFProtein tyrosine phosphatase, receptor type, F. (1914 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
NECTIN3Poliovirus receptor-related 3. (549 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
NRXN2NRXN2 isoform 2. (1712 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
NLGN4YNeuroligin 4 Y-linked. (873 aa)
NECTIN1NECTIN1 isoform 1. (517 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
PDCD1Programmed cell death 1. (288 aa)
PECAM1Platelet/endothelial cell adhesion molecule. (745 aa)
BV7-9TRBV7-9 isoform 1. (155 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
LOC751057CD99 isoform 1. (200 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
F11RF11R isoform 1. (322 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
CLDN34CLDN34 isoform 1. (214 aa)
NECTIN2Poliovirus receptor-related 2 (Herpesvirus entry mediator B). (542 aa)
IGSF11Immunoglobulin superfamily member 11. (431 aa)
ICOSLGICOSLG isoform 3. (590 aa)
ITGB2Integrin beta. (863 aa)
CD6CD6 isoform 1. (675 aa)
MPZL1Myelin protein zero-like 1. (269 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
PATR-EPatr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)
ICAM3Intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. (554 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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