(56 nodes) Adherens junction network (Pan troglodytes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WASF2	WAS protein family, member 2. (498 aa)
	ENSPTRP00000000715	Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
	CTNNA3	CTNNA3 isoform 1. (895 aa)
	PTPRJ	PTPRJ isoform 4. (1312 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1748 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1364 aa)
	CDH1	CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
	PTPRM	PTPRM isoform 4. (1465 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	EP300	E1A binding protein p300. (2175 aa)
	RHOA	Ras homolog family member A. (193 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	CTNNA1	CTNNA1 isoform 21. (906 aa)
	WASL	WASP like actin nucleation promoting factor. (505 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	WASF3	WH2 domain-containing protein. (502 aa)
	PARD3	PARD3 isoform 2. (1356 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	WASF1	Wiskott-Aldrich syndrome protein family member 1. (559 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	CSNK2A2	Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
	AFDN	Afadin, adherens junction formation factor. (1834 aa)
	INSR	Tyrosine-protein kinase receptor. (1408 aa)
	FGFR1	Fibroblast growth factor receptor. (854 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	WAS	WAS isoform 1. (502 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	PTPRF	Protein tyrosine phosphatase, receptor type, F. (1914 aa)
	NECTIN4	Nectin cell adhesion molecule 4. (510 aa)
	CREBBP	CREB binding protein. (2442 aa)
	NECTIN3	Poliovirus receptor-related 3. (549 aa)
	CTNNA2	CTNNA2 isoform 11. (953 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	SSX2IP	Synovial sarcoma, X breakpoint 2 interacting protein. (614 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	CDC42	Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	NECTIN1	NECTIN1 isoform 1. (517 aa)
	ACTN4	Actinin, alpha 4. (931 aa)
	TCF7	Transcription factor 7. (481 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1054 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	CTNND1	CTNND1 isoform 23. (975 aa)
	NECTIN2	Poliovirus receptor-related 2 (Herpesvirus entry mediator B). (542 aa)
	CSNK2A1	Casein kinase 2, alpha 1 polypeptide; Belongs to the protein kinase superfamily. (391 aa)
	YES1	Tyrosine-protein kinase. (558 aa)
	PTPRB	PTPRB isoform 1. (2215 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTN4	ENSPTRP00000058292	ENSPTRP00000080234	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Actinin, alpha 4.	0.950
ACTB	AFDN	ENSPTRP00000058292	ENSPTRP00000061867	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Afadin, adherens junction formation factor.	0.932
ACTB	CDC42	ENSPTRP00000058292	ENSPTRP00000077648	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.955
ACTB	CDH1	ENSPTRP00000058292	ENSPTRP00000014119	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins.	0.590
ACTB	CREBBP	ENSPTRP00000058292	ENSPTRP00000074980	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CREB binding protein.	0.430
ACTB	CTNNA1	ENSPTRP00000058292	ENSPTRP00000029566	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CTNNA1 isoform 21.	0.943
ACTB	CTNNA2	ENSPTRP00000058292	ENSPTRP00000075894	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CTNNA2 isoform 11.	0.923
ACTB	CTNNA3	ENSPTRP00000058292	ENSPTRP00000004385	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CTNNA3 isoform 1.	0.923
ACTB	CTNNB1	ENSPTRP00000058292	ENSPTRP00000044466	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.637
ACTB	EGFR	ENSPTRP00000058292	ENSPTRP00000069741	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Receptor protein-tyrosine kinase.	0.604
ACTB	ENSPTRP00000000715	ENSPTRP00000058292	ENSPTRP00000000715	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Wiskott-Aldrich syndrome protein family member 2-like.	0.929
ACTB	EP300	ENSPTRP00000058292	ENSPTRP00000024841	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	E1A binding protein p300.	0.462
ACTB	ERBB2	ENSPTRP00000058292	ENSPTRP00000069840	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Receptor protein-tyrosine kinase.	0.617
ACTB	FYN	ENSPTRP00000058292	ENSPTRP00000077482	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase.	0.498
ACTB	IGF1R	ENSPTRP00000058292	ENSPTRP00000012792	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase receptor.	0.451
ACTB	INSR	ENSPTRP00000058292	ENSPTRP00000063257	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase receptor.	0.463
ACTB	IQGAP1	ENSPTRP00000058292	ENSPTRP00000012743	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	IQ motif containing GTPase activating protein 1.	0.963
ACTB	MAPK1	ENSPTRP00000058292	ENSPTRP00000024313	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.516
ACTB	MAPK3	ENSPTRP00000058292	ENSPTRP00000053615	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.592
ACTB	MET	ENSPTRP00000058292	ENSPTRP00000083162	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.429