STRINGSTRING
CLDN19 CLDN19 PRKAA2 PRKAA2 PATJ PATJ RAB13 RAB13 CD1A CD1A CD1C CD1C TUBAL3 TUBAL3 PPP2R2D PPP2R2D AMOTL1 AMOTL1 PPP2R1B PPP2R1B YBX3 YBX3 TUBA1A TUBA1A PRKAB1 PRKAB1 MPP5 MPP5 TJP1 TJP1 CGNL1 CGNL1 PARD6A PARD6A CLDN7 CLDN7 SLC9A3R1 SLC9A3R1 MYL12B MYL12B PARD6G PARD6G STK11 STK11 TJP3 TJP3 CRB3 CRB3 PRKACA PRKACA RAB8A RAB8A PRKCE PRKCE LOC107973630 LOC107973630 PRKAG3 PRKAG3 TUBA4A TUBA4A PCNA PCNA MYL9 MYL9 CLDN17 CLDN17 CLDN8 CLDN8 TIAM1 TIAM1 CLDN14 CLDN14 PEX26 PEX26 RHOA RHOA MAGI1 MAGI1 HCLS1 HCLS1 CLDN18 CLDN18 CLDN11 CLDN11 CLDN1 CLDN1 CLDN16 CLDN16 CLDN22 CLDN22 CLDN24 CLDN24 MARVELD2 MARVELD2 HSPA4 HSPA4 MAPK9 MAPK9 BVES BVES CLDN20 CLDN20 CFTR CFTR ACTR3B ACTR3B PRKACG PRKACG EPB41L4B EPB41L4B AMOT AMOT CDK4 CDK4 MAPK8 MAPK8 PRKACB PRKACB PARD3 PARD3 IGSF5 IGSF5 MAP3K5 MAP3K5 ARHGEF18 ARHGEF18 SYNPO SYNPO CLDN3 CLDN3 PRKAA1 PRKAA1 MAP3K1 MAP3K1 MPP4 MPP4 WHAMM WHAMM CD1E CD1E MARVELD3 MARVELD3 OCLN OCLN CLDN15 CLDN15 JAM2 JAM2 ACTB ACTB CLDN23 CLDN23 CD1D CD1D CLDN25 CLDN25 CLDN4 CLDN4 LLGL2 LLGL2 AFDN AFDN RAB8B RAB8B NEDD4L NEDD4L ROCK2 ROCK2 PPP2CA PPP2CA MYH11 MYH11 SYMPK SYMPK MYL12A MYL12A ACTR3C ACTR3C RAP2C-2 RAP2C-2 MYH14 MYH14 TUBA1B TUBA1B DLG1 DLG1 PRKCI PRKCI PPP2R2A PPP2R2A WAS WAS MYH10 MYH10 ITGB1 ITGB1 DLG3 DLG3 ERBB2 ERBB2 MAPK10 MAPK10 ARHGEF2 ARHGEF2 TUBA1C TUBA1C NF2 NF2 RDX RDX JAM3 JAM3 CLDN2 CLDN2 CGN CGN GATA4 GATA4 MPDZ MPDZ RAPGEF6 RAPGEF6 CACNA1D CACNA1D SRC SRC CDC42 CDC42 PRKAG2-2 PRKAG2-2 MYH9 MYH9 PRKAB2 PRKAB2 PPP2R2B PPP2R2B RAPGEF2 RAPGEF2 MYL2 MYL2 ACTN4 ACTN4 PPP2R1A PPP2R1A RAP1A RAP1A ROCK1 ROCK1 PARD6B PARD6B NEDD4 NEDD4 CCND1 CCND1 F11R F11R MSN MSN PPP2CB PPP2CB CLDN9 CLDN9 AMOTL2 AMOTL2 MICALL2 MICALL2 MYL6 MYL6 CLDN34 CLDN34 PPP2R2C PPP2R2C VASP VASP TJAP1 TJAP1 ACTR2 ACTR2 RUNX1 RUNX1 PRKAG1 PRKAG1 DLG2 DLG2 EZR EZR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PATJPATJ isoform 2. (1801 aa)
RAB13RAB13, member RAS oncogene family. (203 aa)
CD1ACD1A isoform 1. (327 aa)
CD1CCD1C isoform 1. (333 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
AMOTL1Angiomotin like 1. (956 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
YBX3Cold shock domain protein A. (374 aa)
TUBA1ADetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). (451 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1748 aa)
CGNL1CGNL1 isoform 1. (1303 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
CLDN7Claudin-7. (211 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
MYL12BMyosin light chain 12B. (172 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (928 aa)
CRB3CRB3 isoform 3. (125 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC107973630Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MYL9Myosin, light chain 9, regulatory. (172 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
PEX26Tubulin alpha-8 chain. (454 aa)
RHOARas homolog family member A. (193 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1458 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (305 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
MARVELD2MARVELD2 isoform 3. (559 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (840 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BVESBlood vessel epicardial substance. (360 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
ACTR3BARP3 actin-related protein 3 homolog B; Belongs to the actin family. (418 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
EPB41L4BEPB41L4B isoform 2. (938 aa)
AMOTAMOT isoform 2. (1094 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PARD3PARD3 isoform 2. (1356 aa)
IGSF5LOW QUALITY PROTEIN: immunoglobulin superfamily member 5. (405 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X6. (1015 aa)
SYNPOSYNPO isoform 4. (899 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MAP3K1MAP3K1 isoform 1. (1509 aa)
MPP4MPP4 isoform 2; Belongs to the MAGUK family. (636 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (813 aa)
CD1ECD1E isoform 2. (388 aa)
MARVELD3MARVEL domain containing 3. (410 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
JAM2Junctional adhesion molecule 2. (312 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (290 aa)
CD1DAntigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. (335 aa)
CLDN25CLDN25 isoform 1. (229 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1041 aa)
AFDNAfadin, adherens junction formation factor. (1834 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
MYH11MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
SYMPKSYMPK isoform 3. (1310 aa)
MYL12AMyosin light chain 12A. (177 aa)
ACTR3CActin-related protein 3C isoform X1. (239 aa)
RAP2C-2RAP2C, member of RAS oncogene family. (183 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (458 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
WASWAS isoform 1. (502 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (519 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
RDXRDX isoform 3. (609 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
CGNCGN isoform 6. (1210 aa)
GATA4GATA binding protein 4. (443 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2084 aa)
RAPGEF6T0093430 isoform 1. (1609 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SRCTyrosine-protein kinase. (542 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
ACTN4Actinin, alpha 4. (931 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
F11RF11R isoform 1. (322 aa)
MSNMSN isoform 1. (577 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
AMOTL2AMOTL2 isoform 6. (837 aa)
MICALL2MICALL2 isoform 11. (906 aa)
MYL6MYL6 isoform 8. (233 aa)
CLDN34CLDN34 isoform 1. (214 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (469 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
TJAP1Tight junction associated protein 1. (557 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
EZREZR isoform 1. (671 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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