(64 nodes) Antigen processing and presentation network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPA5	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
	CTSS	CTSS isoform 1; Belongs to the peptidase C1 family. (331 aa)
	RFX5	Regulatory factor X, 5 (Influences HLA class II expression). (616 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	RFXAP	Regulatory factor X associated protein. (272 aa)
	PSME1	Proteasome (Prosome, macropain) activator subunit 1 (PA28 alpha). (250 aa)
	PSME2	Proteasome (Prosome, macropain) activator subunit 2 (PA28 beta). (239 aa)
	LGMN	LGMN isoform 1. (433 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1131 aa)
	CALR	Calreticulin. (414 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (840 aa)
	CANX	CANX isoform 1. (592 aa)
	PATR-DRA	MHC class II protein; Belongs to the MHC class II family. (254 aa)
	HLA-DQB1	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa)
	PATR-DOB	Patr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa)
	PATR-DMB	HLA-DMB isoform 5. (263 aa)
	MAMU-DMA	HLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
	HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
	TAPBP	TAP binding protein. (466 aa)
	HSP90AB1	HSP90AB1 isoform 1. (688 aa)
	CTSB	CTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
	CTSL	CTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
	TAP1	TAP1 isoform 1. (808 aa)
	ENSPTRP00000048486	Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X1. (305 aa)
	LOC107969810	LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DL5A. (373 aa)
	HSPA1L	HSPA1L isoform 1; Belongs to the heat shock protein 70 family. (641 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	KIR3DX1-2	KIR3DX1 isoform 7. (365 aa)
	LOC104006793	HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa)
	PATR-F	Patr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa)
	KLRC3	NKG2-E type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (261 aa)
	KLRK1-2	NKG2-F type II integral membrane protein; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells. (158 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
	HLA-DQA1	HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa)
	PATR-G	Patr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
	KIR3DL1-2	KIR3DL1 isoform 2. (446 aa)
	HLA-DPB1	Major histocompatibility complex, class II, DP beta 1. (258 aa)
	KLRD1	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
	CD8B	CD8B isoform 3. (243 aa)
	PATR-DQB1	HLA-DRB1 isoform 1. (271 aa)
	KLRC1	NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (233 aa)
	LOC745166	HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
	ENSPTRP00000060619	LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (632 aa)
	PSME3-2	Proteasome activator subunit 3. (265 aa)
	PATR-B	Patr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa)
	ENSPTRP00000066786	LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa)
	CD8A	CD8A isoform 1. (235 aa)
	PATR-AL	Major histocompatibility complex, class I, AL precursor. (365 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	IFI30	IFI30 lysosomal thiol reductase. (259 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	HSPA2	Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	LOC748740	HSPA6 isoform 1; Belongs to the heat shock protein 70 family. (644 aa)
	BV7-9	TRBV7-9 isoform 1. (155 aa)
	TAP2	Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP). (724 aa)
	KIR2DL6-2	KIR2DL4 isoform 7. (416 aa)
	LOC107968084	Heat shock protein HSP 90-beta-like. (361 aa)
	LOC473484	Cathepsin L1. (276 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (208 aa)
	PATR-E	Patr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	BV7-9	ENSPTRP00000011997	ENSPTRP00000082360	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	TRBV7-9 isoform 1.	0.808
B2M	CALR	ENSPTRP00000011997	ENSPTRP00000018010	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Calreticulin.	0.910
B2M	CANX	ENSPTRP00000011997	ENSPTRP00000030101	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	CANX isoform 1.	0.501
B2M	CD4	ENSPTRP00000011997	ENSPTRP00000054833	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.742
B2M	CD8A	ENSPTRP00000011997	ENSPTRP00000067343	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	CD8A isoform 1.	0.835
B2M	CD8B	ENSPTRP00000011997	ENSPTRP00000059042	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	CD8B isoform 3.	0.656
B2M	ENSPTRP00000048486	ENSPTRP00000011997	ENSPTRP00000048486	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X1.	0.823
B2M	ENSPTRP00000066786	ENSPTRP00000011997	ENSPTRP00000066786	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain.	0.962
B2M	HLA-DOA	ENSPTRP00000011997	ENSPTRP00000030784	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	0.604
B2M	HLA-DPA1	ENSPTRP00000011997	ENSPTRP00000030785	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family.	0.571
B2M	HLA-DPB1	ENSPTRP00000011997	ENSPTRP00000056904	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Major histocompatibility complex, class II, DP beta 1.	0.603
B2M	HLA-DQA1	ENSPTRP00000011997	ENSPTRP00000055403	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	HLA-DQA2 isoform 1; Belongs to the MHC class II family.	0.562
B2M	HLA-DQB1	ENSPTRP00000011997	ENSPTRP00000030768	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3.	0.603
B2M	IFNG	ENSPTRP00000011997	ENSPTRP00000008822	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.516
B2M	KIR2DL6-2	ENSPTRP00000011997	ENSPTRP00000086730	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	KIR2DL4 isoform 7.	0.516
B2M	KLRC1	ENSPTRP00000011997	ENSPTRP00000059579	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.453
B2M	KLRD1	ENSPTRP00000011997	ENSPTRP00000057110	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.660
B2M	LGMN	ENSPTRP00000011997	ENSPTRP00000011347	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	LGMN isoform 1.	0.483
B2M	LOC104006793	ENSPTRP00000011997	ENSPTRP00000054452	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	HLA class II histocompatibility antigen, DR beta 3 chain precursor.	0.603
B2M	MAMU-DMA	ENSPTRP00000011997	ENSPTRP00000030781	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	HLA class II histocompatibility antigen, DM alpha chain isoform X1.	0.547