(59 nodes) RIG-I-like receptor signaling pathway network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIKE1	Suppressor of IKBKE 1. (211 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	NLRX1	NLRX1 isoform 1. (975 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58. (678 aa)
	TBKBP1	TBK1 binding protein 1. (615 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	IFIH1	IFIH1 isoform 1. (1025 aa)
	CASP8	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
	MAVS	Mitochondrial antiviral signaling protein. (449 aa)
	AZI2	5-azacytidine induced 2. (392 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
	CXCL10	C-X-C motif chemokine. (96 aa)
	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	RIPK1	Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
	MAPK14	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	IKBKB	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
	IFNB1	Interferon beta 1. (187 aa)
	IFNA21	Interferon alpha 21. (189 aa)
	IFNA2	IFNA2 isoform 1. (170 aa)
	IFNA5	Interferon alpha 5. (189 aa)
	IFNE	Interferon, epsilon. (208 aa)
	IFNK	IFNK isoform 1. (208 aa)
	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (925 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	STING1	TMEM173 isoform 2. (379 aa)
	TRADD	TNFRSF1A-associated via death domain. (312 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)
	MAP3K1	MAP3K1 isoform 1. (1509 aa)
	RELA	V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
	MAPK12	Mitogen-activated protein kinase. (370 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	NFKBIB	NFKB inhibitor beta. (270 aa)
	ISG15	ISG15 ubiquitin-like modifier. (165 aa)
	IFNA6	Interferon alpha 6. (190 aa)
	CASP10	CASP10 isoform 4; Belongs to the peptidase C14A family. (523 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
	IFNA17	IFNA17 isoform 1. (189 aa)
	MAPK10	Mitogen-activated protein kinase. (551 aa)
	IFNA14	Interferon alpha 14. (189 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	IKBKE	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (716 aa)
	LOC100610002	IKBKG isoform 9. (401 aa)
	CK820_G0014527	IFNA13 isoform 2. (198 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
	IFNA8	Interferon alpha 8. (189 aa)
	LOC741747	IFNA7 isoform 1. (189 aa)
	RNF125	Ring finger protein 125. (232 aa)
	LOC742651	IFNA1 isoform 1. (195 aa)
	TKFC	Dihydroxyacetone kinase 2 homolog. (576 aa)
	IFNW1	IFNW1 isoform 1. (200 aa)
	TANK	TANK isoform 1. (483 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSPTRP00000048113	ENSPTRP00000031526	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP8	ENSPTRP00000048113	ENSPTRP00000021879	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.674
ATG12	DDX58	ENSPTRP00000048113	ENSPTRP00000035647	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58.	0.986
ATG12	DHX58	ENSPTRP00000048113	ENSPTRP00000015656	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.519
ATG12	FADD	ENSPTRP00000048113	ENSPTRP00000006883	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.816
ATG12	IFIH1	ENSPTRP00000048113	ENSPTRP00000021498	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	IFIH1 isoform 1.	0.849
ATG12	MAVS	ENSPTRP00000048113	ENSPTRP00000022642	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.991
ATG12	NLRX1	ENSPTRP00000048113	ENSPTRP00000007493	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLRX1 isoform 1.	0.720
ATG12	RIPK1	ENSPTRP00000048113	ENSPTRP00000030180	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.480
ATG5	ATG12	ENSPTRP00000031526	ENSPTRP00000048113	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSPTRP00000031526	ENSPTRP00000063394	Autophagy protein 5; Involved in autophagic vesicle formation.	CASP10 isoform 4; Belongs to the peptidase C14A family.	0.518
ATG5	CASP8	ENSPTRP00000031526	ENSPTRP00000021879	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.820
ATG5	DDX58	ENSPTRP00000031526	ENSPTRP00000035647	Autophagy protein 5; Involved in autophagic vesicle formation.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58.	0.986
ATG5	DHX58	ENSPTRP00000031526	ENSPTRP00000015656	Autophagy protein 5; Involved in autophagic vesicle formation.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.533
ATG5	FADD	ENSPTRP00000031526	ENSPTRP00000006883	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.869
ATG5	IFIH1	ENSPTRP00000031526	ENSPTRP00000021498	Autophagy protein 5; Involved in autophagic vesicle formation.	IFIH1 isoform 1.	0.817
ATG5	MAPK8	ENSPTRP00000031526	ENSPTRP00000040692	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitogen-activated protein kinase.	0.413
ATG5	MAVS	ENSPTRP00000031526	ENSPTRP00000022642	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.992
ATG5	NLRX1	ENSPTRP00000031526	ENSPTRP00000007493	Autophagy protein 5; Involved in autophagic vesicle formation.	NLRX1 isoform 1.	0.739
ATG5	RIPK1	ENSPTRP00000031526	ENSPTRP00000030180	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.703