STRINGSTRING
PLK3 PLK3 BCL10 BCL10 NRAS NRAS PTGS2 PTGS2 MAPKAPK2 MAPKAPK2 IL10 IL10 NLRP3 NLRP3 CALML5 CALML5 EGR2 EGR2 HRAS HRAS RRAS2 RRAS2 PAK1 PAK1 CLEC4D CLEC4D CLEC4E CLEC4E CLEC1B CLEC1B IL23A IL23A NFKBIA NFKBIA MALT1 MALT1 PIK3R2 PIK3R2 CALM3 CALM3 RRAS RRAS IL1B IL1B CASP8 CASP8 MAPK1 MAPK1 ITPR2 ITPR2 ITPR1 ITPR1 RHOA RHOA PRKCD PRKCD CBLB CBLB MRAS MRAS PIK3CB PIK3CB NFKB1 NFKB1 IL2 IL2 IRF1 IRF1 IL12B IL12B MAPK9 MAPK9 ITPR3 ITPR3 MAPK14 MAPK14 EGR3 EGR3 IKBKB IKBKB MAPK8 MAPK8 CALML6 CALML6 NFATC2 NFATC2 BCL3 BCL3 CLEC6A CLEC6A FCER1G FCER1G MAPK3 MAPK3 IL17D IL17D RELA RELA CLEC4M CLEC4M IRF9 IRF9 MAPK12 MAPK12 MAP3K14 MAP3K14 ARHGEF12 ARHGEF12 CD209L2 CD209L2 PTPN11 PTPN11 PIK3R3 PIK3R3 CALML3 CALML3 PPP3CB PPP3CB LSP1 LSP1 NFKB2 NFKB2 PPP3CA PPP3CA IL6 IL6 CD209 CD209 MAPK10 MAPK10 PPP3CC PPP3CC MAPK11 MAPK11 SYK SYK IKBKE IKBKE LOC100610002 LOC100610002 PLCG2 PLCG2 SRC SRC PIK3R1 PIK3R1 CCL22 CCL22 CASP1 CASP1 AKT1 AKT1 CCL17 CCL17 CHUK CHUK KRAS KRAS AKT3 AKT3 NFATC3 NFATC3 RELB RELB NFATC4 NFATC4 AKT2 AKT2 STAT1 STAT1 STAT2 STAT2 CARD9 CARD9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLK3Serine/threonine-protein kinase PLK. (673 aa)
BCL10B-cell CLL/lymphoma 10. (316 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
NLRP3NLRP3 isoform 2. (1025 aa)
CALML5Calmodulin like 5. (146 aa)
EGR2Early growth response 2. (476 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
RRAS2Related RAS viral (R-ras) oncogene homolog 2. (204 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
CLEC4DCLEC4D isoform 2. (215 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
CLEC1BCLEC1B isoform 3. (228 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
MALT1Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
RRASRelated RAS viral (R-ras) oncogene homolog. (218 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
RHOARas homolog family member A. (193 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IRF1Interferon regulatory factor. (325 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
EGR3Early growth response 3. (387 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CALML6Calmodulin like 6. (181 aa)
NFATC2NFATC2 isoform 4. (938 aa)
BCL3BCL3 transcription coactivator. (454 aa)
CLEC6AC-type lectin domain family 6 member A. (208 aa)
FCER1GFc fragment of IgE receptor Ig. (112 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL17DIL17D isoform 2. (209 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
CLEC4MC-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (445 aa)
IRF9Interferon regulatory factor 9. (391 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
CD209L2CD209 isoform 3. (256 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
LSP1LSP1 isoform 9. (466 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (256 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SYKTyrosine-protein kinase. (635 aa)
IKBKEInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (716 aa)
LOC100610002IKBKG isoform 9. (401 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CCL22C-C motif chemokine. (93 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CCL17C-C motif chemokine. (94 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
RELBRELB isoform 3. (567 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
CARD9Caspase recruitment domain family, member 9. (536 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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