STRINGSTRING
JAK1 JAK1 IL12RB2 IL12RB2 IL2RA IL2RA MAML2 MAML2 CD3E CD3E CD3G CD3G STAT6 STAT6 IFNG IFNG NFKBIA NFKBIA IL4R IL4R TBX21 TBX21 NOTCH3 NOTCH3 ZAP70 ZAP70 JAG1 JAG1 PLCG1 PLCG1 RBPJL RBPJL MAPK1 MAPK1 IL2RB IL2RB NFKB1 NFKB1 IL2 IL2 IL12B IL12B MAPK9 MAPK9 PATR-DRA PATR-DRA HLA-DQB1 HLA-DQB1 PATR-DOB PATR-DOB PATR-DMB PATR-DMB MAMU-DMA MAMU-DMA HLA-DOA HLA-DOA HLA-DPA1 HLA-DPA1 MAPK14 MAPK14 NFKBIE NFKBIE DLL1 DLL1 IKBKB IKBKB NOTCH1 NOTCH1 MAPK8 MAPK8 CD247 CD247 IL13-2 IL13-2 IL12RB1 IL12RB1 NFATC2 NFATC2 IL2RG IL2RG TYK2 TYK2 IFNGR1 IFNGR1 MAPK3 MAPK3 RELA RELA LOC104006793 LOC104006793 CD4 CD4 HLA-DQA1 HLA-DQA1 MAPK12 MAPK12 MAML1 MAML1 HLA-DPB1 HLA-DPB1 LAT LAT NFKBIB NFKBIB PATR-DQB1 PATR-DQB1 DLL3 DLL3 GATA3 GATA3 PPP3CB PPP3CB PPP3CA PPP3CA MAPK10 MAPK10 PPP3CC PPP3CC MAPK11 MAPK11 MAF MAF NOTCH2 NOTCH2 LOC100610002 LOC100610002 FOS FOS RBPJ RBPJ PRKCQ PRKCQ STAT4 STAT4 MAML3 MAML3 IL5 IL5 BV7-9 BV7-9 CHUK CHUK NFATC3 NFATC3 STAT1 STAT1 IFNGR2-2 IFNGR2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1154 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (862 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
CD3ECD3E isoform 2. (207 aa)
CD3GCD3G isoform 1. (182 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
IL4RIL4R isoform 2. (827 aa)
TBX21T-box transcription factor 21. (535 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
IL2RBInterleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PATR-DRAMHC class II protein; Belongs to the MHC class II family. (254 aa)
HLA-DQB1HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa)
PATR-DOBPatr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa)
PATR-DMBHLA-DMB isoform 5. (263 aa)
MAMU-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
NFKBIENFKB inhibitor epsilon. (500 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CD247CD247 isoform 2. (163 aa)
IL13-2Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
IL12RB1IL12RB1 isoform 1. (662 aa)
NFATC2NFATC2 isoform 4. (938 aa)
IL2RGIL2RG isoform 1. (369 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
LOC104006793HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
HLA-DQA1HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAML1MAML1 isoform 1. (1016 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
LATLinker for activation of T cells. (268 aa)
NFKBIBNFKB inhibitor beta. (270 aa)
PATR-DQB1HLA-DRB1 isoform 1. (271 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
GATA3GATA binding protein 3. (444 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAFMAF isoform 2; Belongs to the bZIP family. (402 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
LOC100610002IKBKG isoform 9. (401 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
MAML3MAML3 isoform 1. (1134 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
BV7-9TRBV7-9 isoform 1. (155 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IFNGR2-2IFNGR2 isoform 6. (302 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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