STRINGSTRING
BCL10 BCL10 NRAS NRAS PTPRC PTPRC IL10 IL10 MAP3K8 MAP3K8 HRAS HRAS PAK1 PAK1 CD3E CD3E CD3G CD3G IFNG IFNG NFKBIA NFKBIA PAK6 PAK6 GRB2 GRB2 MALT1 MALT1 MAP2K2 MAP2K2 VAV1 VAV1 PIK3R2 PIK3R2 ZAP70 ZAP70 NCK2 NCK2 CD28 CD28 ICOS ICOS PAK5 PAK5 PLCG1 PLCG1 MAPK1 MAPK1 GRAP2 GRAP2 RHOA RHOA CBLB CBLB NCK1 NCK1 PIK3CB PIK3CB NFKB1 NFKB1 IL2 IL2 CSF2 CSF2 ITK ITK LCP2 LCP2 MAPK9 MAPK9 MAPK14 MAPK14 NFKBIE NFKBIE IKBKB IKBKB CDK4 CDK4 MAPK8 MAPK8 SOS2 SOS2 CD247 CD247 NFATC2 NFATC2 PTPN6 PTPN6 SOS1 SOS1 MAPK3 MAPK3 RELA RELA CD4 CD4 MAPK12 MAPK12 MAP3K14 MAP3K14 LAT LAT MAP3K7 MAP3K7 NFKBIB NFKBIB CD8B CD8B PAK3 PAK3 MAP2K1 MAP2K1 PIK3R3 PIK3R3 PPP3CB PPP3CB DLG1 DLG1 CD8A CD8A PPP3CA PPP3CA MAPK10 MAPK10 TEC TEC RASGRP1 RASGRP1 PPP3CC PPP3CC MAPK11 MAPK11 LOC100610002 LOC100610002 PIK3R1 PIK3R1 FYN FYN CD40LG CD40LG CDC42 CDC42 FOS FOS PRKCQ PRKCQ CTLA4 CTLA4 PDCD1 PDCD1 GSK3B GSK3B IL5 IL5 BV7-9 BV7-9 AKT1 AKT1 VAV2 VAV2 CHUK CHUK KRAS KRAS AKT3 AKT3 NFATC3 NFATC3 AKT2 AKT2 PAK4 PAK4 VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL10B-cell CLL/lymphoma 10. (316 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
CD3ECD3E isoform 2. (207 aa)
CD3GCD3G isoform 1. (182 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MALT1Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NCK2Cytoplasmic protein. (380 aa)
CD28CD28 isoform 3. (220 aa)
ICOSInducible T cell costimulator. (199 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
RHOARas homolog family member A. (193 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CSF2Colony stimulating factor 2. (144 aa)
ITKTyrosine-protein kinase. (620 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
NFKBIENFKB inhibitor epsilon. (500 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CD247CD247 isoform 2. (163 aa)
NFATC2NFATC2 isoform 4. (938 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
LATLinker for activation of T cells. (268 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKBIBNFKB inhibitor beta. (270 aa)
CD8BCD8B isoform 3. (243 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
CD8ACD8A isoform 1. (235 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
TECTyrosine-protein kinase. (631 aa)
RASGRP1RASGRP1 isoform 4. (848 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LOC100610002IKBKG isoform 9. (401 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
FYNTyrosine-protein kinase. (537 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
PDCD1Programmed cell death 1. (288 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
BV7-9TRBV7-9 isoform 1. (155 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
VAV3VAV3 isoform 2. (927 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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