STRINGSTRING
BCL10 BCL10 NRAS NRAS BLNK BLNK PIK3AP1 PIK3AP1 HRAS HRAS INPPL1 INPPL1 NFKBIA NFKBIA PRKCB PRKCB GRB2 GRB2 MALT1 MALT1 MAP2K2 MAP2K2 VAV1 VAV1 PIK3R2 PIK3R2 CD22 CD22 CD79A CD79A LILRA5 LILRA5 LILRB1 LILRB1 RASGRP3 RASGRP3 INPP5D INPP5D MAPK1 MAPK1 PIK3CB PIK3CB DAPP1 DAPP1 NFKB1 NFKB1 NFKBIE NFKBIE IKBKB IKBKB CD72 CD72 BTK BTK SOS2 SOS2 LYN LYN NFATC2 NFATC2 IFITM1 IFITM1 PTPN6 PTPN6 SOS1 SOS1 MAPK3 MAPK3 LILRA6 LILRA6 RELA RELA NFKBIB NFKBIB MAP2K1 MAP2K1 PIK3R3 PIK3R3 PPP3CB PPP3CB PPP3CA PPP3CA LILRA4 LILRA4 LILRB3-2 LILRB3-2 PPP3CC PPP3CC CD81 CD81 SYK SYK LOC100610002 LOC100610002 PLCG2 PLCG2 PIK3R1 PIK3R1 FOS FOS CD19 CD19 LOC100612450 LOC100612450 GSK3B GSK3B AKT1 AKT1 VAV2 VAV2 CHUK CHUK KRAS KRAS AKT3 AKT3 NFATC3 NFATC3 AKT2 AKT2 VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL10B-cell CLL/lymphoma 10. (316 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
BLNKBLNK isoform 2. (456 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (1258 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MALT1Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
CD22B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
CD79ACD79A isoform 1. (226 aa)
LILRA5LILRA5 isoform 1. (299 aa)
LILRB1LILRB1 isoform 3. (697 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
NFKBIENFKB inhibitor epsilon. (500 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
CD72CD72 isoform 2. (359 aa)
BTKBTK isoform 2. (693 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
LYNTyrosine-protein kinase. (512 aa)
NFATC2NFATC2 isoform 4. (938 aa)
IFITM1IFITM2 isoform 1. (125 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LILRA6Leukocyte immunoglobulin-like receptor subfamily A member 6; May act as receptor for class I MHC antigens. (481 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
NFKBIBNFKB inhibitor beta. (270 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LILRA4T0147887 isoform 2. (499 aa)
LILRB3-2LILRB3 isoform 3. (643 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
CD81CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (303 aa)
SYKTyrosine-protein kinase. (635 aa)
LOC100610002IKBKG isoform 9. (401 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CD19CD19 isoform 1. (557 aa)
LOC100612450Leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1. (446 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VAV3VAV3 isoform 2. (927 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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