STRINGSTRING
WASF2 WASF2 ENSPTRP00000000715 ENSPTRP00000000715 MARCKSL1 MARCKSL1 FCGR1A FCGR1A ARPC5 ARPC5 PLA2G4A PLA2G4A PTPRC PTPRC DOCK1 DOCK1 RPS6KB2 RPS6KB2 INPPL1 INPPL1 PAK1 PAK1 CFL2 CFL2 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PRKCB PRKCB PLD2 PLD2 RPS6KB1 RPS6KB1 PRKCA PRKCA PLPP2 PLPP2 PIP5K1C PIP5K1C VAV1 VAV1 PIK3R2 PIK3R2 SPHK2 SPHK2 PRKCG PRKCG PRKCE PRKCE INPP5D INPP5D HCK HCK PLCG1 PLCG1 MAPK1 MAPK1 PRKCD PRKCD PIK3CB PIK3CB MYO10 MYO10 PLPP1 PLPP1 MARCKS MARCKS NCF1 NCF1 ARPC1A ARPC1A ARPC1B ARPC1B ASAP1 ASAP1 GSN GSN ARPC5L ARPC5L AMPH AMPH WASF3 WASF3 FCGR2A FCGR2A PLD1 PLD1 GAB2 GAB2 WASF1 WASF1 LYN LYN CRKL CRKL LIMK2 LIMK2 SPHK1 SPHK1 MAPK3 MAPK3 LAT LAT LOC749464 LOC749464 MAP2K1 MAP2K1 PIK3R3 PIK3R3 ASAP3 ASAP3 WAS WAS ARF6 ARF6 PIP5K1B PIP5K1B DNM2 DNM2 PIP5K1A PIP5K1A ARPC3 ARPC3 SYK SYK PLCG2 PLCG2 PIK3R1 PIK3R1 CDC42 CDC42 PLPP3 PLPP3 LIMK1-2 LIMK1-2 AKT1 AKT1 CRK CRK ASAP2 ASAP2 VAV2 VAV2 ARPC4 ARPC4 LOC745350 LOC745350 AKT3 AKT3 CFL1 CFL1 AKT2 AKT2 ARPC2 ARPC2 PLA2G4F PLA2G4F VAV3 VAV3 VASP VASP SCIN-2 SCIN-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WASF2WAS protein family, member 2. (498 aa)
ENSPTRP00000000715Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
MARCKSL1MARCKSL1 isoform 1. (195 aa)
FCGR1AFCGR1A isoform 2. (373 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
PLA2G4APhospholipase A2. (749 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
DOCK1DOCK1 isoform 1; Belongs to the DOCK family. (1854 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (1258 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
CFL2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLA2G4DPhospholipase A2. (818 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLD2Phospholipase. (933 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PLPP2PLPP2 isoform 5. (309 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
SPHK2Sphingosine kinase 2. (255 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
HCKTyrosine-protein kinase. (526 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
MYO10MYO10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
MARCKSMyristoylated alanine-rich protein kinase C substrate. (332 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin related protein 2/3 complex, subunit 1A/1B. (372 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1129 aa)
GSNGSN isoform 3. (782 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
AMPHAMPH isoform 1. (669 aa)
WASF3WH2 domain-containing protein. (502 aa)
FCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa)
PLD1Phospholipase. (1074 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
LYNTyrosine-protein kinase. (512 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
LIMK2LIMK2 isoform 6. (670 aa)
SPHK1Sphingosine kinase 1. (470 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LATLinker for activation of T cells. (268 aa)
LOC749464Phospholipase A2. (781 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (905 aa)
WASWAS isoform 1. (502 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
DNM2DNM2 isoform 5; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
SYKTyrosine-protein kinase. (635 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
PLPP3T0036865 isoform 1. (342 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (1006 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
ARPC4Actin-related protein 2/3 complex subunit 4 isoform X4. (173 aa)
LOC745350FCGR3A isoform 2. (233 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CFL1CFL1 isoform 2; Belongs to the actin-binding proteins ADF family. (204 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
PLA2G4FPhospholipase A2. (849 aa)
VAV3VAV3 isoform 2. (927 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
SCIN-2SCIN isoform 2. (715 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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