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TNFRSF1B TNFRSF1B VCAM1 VCAM1 CREB3L4 CREB3L4 PTGS2 PTGS2 TRAF5 TRAF5 MAP3K8 MAP3K8 CREB3L1 CREB3L1 RPS6KA4 RPS6KA4 FADD FADD BIRC2 BIRC2 MMP3 MMP3 MMP14 MMP14 RIPK3 RIPK3 NFKBIA NFKBIA TRAF3 TRAF3 NOD2 NOD2 CX3CL1 CX3CL1 MLKL MLKL MAP2K4 MAP2K4 CREB3L3 CREB3L3 PIK3R2 PIK3R2 IL18R1 IL18R1 IL1B IL1B CASP8 CASP8 JAG1 JAG1 MMP9 MMP9 MAPK1 MAPK1 LIF LIF ATF4 ATF4 PIK3CB PIK3CB CXCL6 CXCL6 CXCL1 CXCL1 CXCL5 CXCL5 CXCL3 CXCL3 CXCL10 CXCL10 NFKB1 NFKB1 VEGFC VEGFC CSF2 CSF2 IRF1 IRF1 MAPK9 MAPK9 RIPK1 RIPK1 EDN1 EDN1 LTA LTA MAPK14 MAPK14 TNFAIP3 TNFAIP3 TAB2 TAB2 CREB3L2 CREB3L2 IKBKB IKBKB IFNB1 IFNB1 TRAF1 TRAF1 VEGFD VEGFD MAPK8 MAPK8 ITCH ITCH MAP3K5 MAP3K5 CCL20 CCL20 TRADD TRADD TAB3 TAB3 BCL3 BCL3 JUNB JUNB CREB3 CREB3 MAPK3 MAPK3 CASP3 CASP3 RELA RELA MAPK12 MAPK12 MAP3K14 MAP3K14 DAB2IP DAB2IP ATF6B ATF6B MAP3K7 MAP3K7 ENSPTRP00000061486 ENSPTRP00000061486 MAP2K6 MAP2K6 SELE SELE MAP2K1 MAP2K1 CASP10 CASP10 ATF2 ATF2 PIK3R3 PIK3R3 PGAM5 PGAM5 TNFRSF1A TNFRSF1A RPS6KA5 RPS6KA5 IL15 IL15 IL6 IL6 CCL2 CCL2 DNM1L DNM1L MAPK10 MAPK10 CREB1 CREB1 MAPK11 MAPK11 CASP7 CASP7 LOC100610002 LOC100610002 PIK3R1 PIK3R1 CREB5 CREB5 FOS FOS CFLAR CFLAR CXCL2 CXCL2 AKT1 AKT1 CCL5 CCL5 ICAM1 ICAM1 CHUK CHUK CEBPB CEBPB AKT3 AKT3 AKT2 AKT2 BIRC3 BIRC3 SOCS3 SOCS3 TAB1 TAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF1BTumor necrosis factor receptor superfamily, member 1B. (461 aa)
VCAM1Vascular cell adhesion molecule 1. (650 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
MMP3Matrix metallopeptidase 3 (Stromelysin 1, progelatinase). (477 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
IL18R1Uncharacterized protein. (440 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CXCL6C-X-C motif chemokine. (114 aa)
CXCL1C-X-C motif chemokine. (107 aa)
CXCL5C-X-C motif chemokine. (114 aa)
CXCL3C-X-C motif chemokine. (107 aa)
CXCL10C-X-C motif chemokine. (96 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
CSF2Colony stimulating factor 2. (144 aa)
IRF1Interferon regulatory factor. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
EDN1EDN1 isoform 1. (212 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity). (205 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (790 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
IFNB1Interferon beta 1. (187 aa)
TRAF1TNF receptor-associated factor. (416 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
CCL20C-C motif chemokine. (96 aa)
TRADDTNFRSF1A-associated via death domain. (312 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
BCL3BCL3 transcription coactivator. (454 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSPTRP00000061486Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
SELESELE isoform 1. (612 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
CASP10CASP10 isoform 4; Belongs to the peptidase C14A family. (523 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1. (289 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
CCL2C-C motif chemokine. (109 aa)
DNM1LDNM1L isoform 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CASP7CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)
LOC100610002IKBKG isoform 9. (401 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CREB5CREB5 isoform 1. (508 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
CXCL2C-X-C motif chemokine. (117 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CCL5C-C motif chemokine. (91 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BIRC3Baculoviral IAP repeat containing 3. (610 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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