54 items (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
	CALML5	Calmodulin like 5. (146 aa)
	HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
	GRM5	Glutamate metabotropic receptor 5. (1210 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)
	PPP1R1A	Protein phosphatase 1 regulatory inhibitor subunit 1A. (171 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	PRKACA	PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
	CALM3	Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ATF4	Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
	EP300	E1A binding protein p300. (2175 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
	ITPR1	ITPR1 isoform 3. (2700 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	ITPR3	ITPR3 isoform 1. (2677 aa)
	GRM1	Glutamate receptor, metabotropic 1. (1194 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	CALML6	Calmodulin like 6. (181 aa)
	GNAQ	Guanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	GRIN2A	Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
	RPS6KA2	Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (526 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
	RAP1B	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
	GRIN2C	GRIN2C isoform 4. (1240 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (745 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (666 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (521 aa)
	CREBBP	CREB binding protein. (2442 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
	BRAF	BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	ARAF	V-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY8	ENSPTRP00000032741	ENSPTRP00000077396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	CALM3	ENSPTRP00000032741	ENSPTRP00000019197	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family.	0.959
ADCY1	CALML3	ENSPTRP00000032741	ENSPTRP00000064433	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.955
ADCY1	CALML5	ENSPTRP00000032741	ENSPTRP00000003820	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.956
ADCY1	CALML6	ENSPTRP00000032741	ENSPTRP00000043977	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.949
ADCY1	CAMK2A	ENSPTRP00000032741	ENSPTRP00000080192	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.911
ADCY1	CAMK2B	ENSPTRP00000032741	ENSPTRP00000073307	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.915
ADCY1	PLCB1	ENSPTRP00000032741	ENSPTRP00000022705	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.427
ADCY1	PRKACA	ENSPTRP00000032741	ENSPTRP00000018062	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.939
ADCY1	PRKACB	ENSPTRP00000032741	ENSPTRP00000042330	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.939
ADCY1	PRKACG	ENSPTRP00000032741	ENSPTRP00000035898	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.949
ADCY1	PRKCA	ENSPTRP00000032741	ENSPTRP00000016236	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.737
ADCY1	PRKCB	ENSPTRP00000032741	ENSPTRP00000013479	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.676
ADCY1	PRKCG	ENSPTRP00000032741	ENSPTRP00000019651	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.681
ADCY1	RAPGEF3	ENSPTRP00000032741	ENSPTRP00000008316	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.940
ADCY8	ADCY1	ENSPTRP00000077396	ENSPTRP00000032741	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY8	CALM3	ENSPTRP00000077396	ENSPTRP00000019197	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family.	0.972
ADCY8	CALML3	ENSPTRP00000077396	ENSPTRP00000064433	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.975
ADCY8	CALML5	ENSPTRP00000077396	ENSPTRP00000003820	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.975
ADCY8	CALML6	ENSPTRP00000077396	ENSPTRP00000043977	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.969