STRINGSTRING
GNAI3 GNAI3 GLUL GLUL PLA2G4A PLA2G4A GNG4 GNG4 GNG3 GNG3 GRK2 GRK2 SHANK2 SHANK2 GRM5 GRM5 CACNA1C CACNA1C GRIN2B GRIN2B SLC38A2 SLC38A2 GLS2 GLS2 ADCY4 ADCY4 PLA2G4E PLA2G4E PLA2G4D PLA2G4D GNB5 GNB5 HOMER2 HOMER2 ADCY9 ADCY9 PRKCB PRKCB PLD2 PLD2 DLG4 DLG4 PRKCA PRKCA DLGAP1 DLGAP1 PRKACA PRKACA HOMER3 HOMER3 GRIK5 GRIK5 SLC17A7 SLC17A7 PRKCG PRKCG ADCY3 ADCY3 KCNJ3 KCNJ3 GLS GLS PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 ITPR2 ITPR2 ITPR1 ITPR1 GRM7 GRM7 GNAI2 GNAI2 ADCY5 ADCY5 GNB4 GNB4 GRIA2 GRIA2 GRM6 GRM6 ITPR3 ITPR3 GRIK2 GRIK2 GRM1 GRM1 ADCY1 ADCY1 GRM3 GRM3 GNGT1 GNGT1 GNG11 GNG11 PRKACG PRKACG GNG10 GNG10 GRIN3A GRIN3A PRKACB PRKACB PLD1 PLD1 GNB3 GNB3 SLC17A6 SLC17A6 GNAQ GNAQ GRK3 GRK3 GRM2 GRM2 MAPK3 MAPK3 GRIN2A GRIN2A GNAS GNAS GNGT2 GNGT2 LOC749464 LOC749464 GNG12 GNG12 ADCY7 ADCY7 GNG13 GNG13 LOC104003639 LOC104003639 SHANK3 SHANK3 PPP3CB PPP3CB GNG2 GNG2 SHANK1 SHANK1 SLC1A2 SLC1A2 SLC38A3 SLC38A3 GNB1 GNB1 PPP3CA PPP3CA GNG7 GNG7 GRM4 GRM4 GNAI1 GNAI1 GRIN2C GRIN2C PPP3CC PPP3CC SLC38A1 SLC38A1 GRIA3 GRIA3 CACNA1D CACNA1D GRIK4 GRIK4 ADCY8 ADCY8 SLC17A8 SLC17A8 SLC1A3 SLC1A3 CACNA1A CACNA1A TRPC1 TRPC1 GRM8 GRM8 ADCY2 ADCY2 GRIA4 GRIA4 SLC1A6 SLC1A6 GNB2 GNB2 PLCB3 PLCB3 GRIK1 GRIK1 GNAO1 GNAO1 PLA2G4F PLA2G4F GNG8 GNG8 GRIA1 GRIA1 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
GLULGlutamine synthetase. (373 aa)
PLA2G4APhospholipase A2. (749 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1849 aa)
GRM5Glutamate metabotropic receptor 5. (1210 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
SLC38A2Solute carrier family 38, member 2. (506 aa)
GLS2GLS2 isoform 4. (602 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLA2G4DPhospholipase A2. (818 aa)
GNB5GNB5 isoform 1. (409 aa)
HOMER2Homer scaffold protein 2. (356 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLD2Phospholipase. (933 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
DLGAP1DLG associated protein 1. (977 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
HOMER3HOMER1 isoform 2. (361 aa)
GRIK5GRIK5 isoform 1. (980 aa)
SLC17A7SLC17A7 isoform 1. (570 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GLSGLS isoform 1. (669 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GRM6GRM6 isoform 2. (879 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
GRM1Glutamate receptor, metabotropic 1. (1194 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
GRIN3AGRIN3A isoform 1. (1115 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PLD1Phospholipase. (1074 aa)
GNB3G protein subunit beta 3. (340 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
GNASGNAS isoform 19. (1042 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
LOC749464Phospholipase A2. (781 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
SHANK3SHANK3 isoform 2. (1744 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
SHANK1SHANK1 isoform 3. (2161 aa)
SLC1A2Amino acid transporter. (574 aa)
SLC38A3Solute carrier family 38, member 3. (504 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GRM4Glutamate receptor, metabotropic 4. (912 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
GRIN2CGRIN2C isoform 4. (1240 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
SLC38A1Solute carrier family 38 member 1. (503 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GRIK4Glutamate receptor ionotropic, kainate 4; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). (959 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
SLC17A8SLC17A8 isoform 1. (589 aa)
SLC1A3Amino acid transporter. (542 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
SLC1A6Amino acid transporter. (564 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (949 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PLA2G4FPhospholipase A2. (849 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.