STRINGSTRING
GNAI3 GNAI3 CREB3L4 CREB3L4 KCNJ9 KCNJ9 GNG4 GNG4 CALML5 CALML5 SLC18A2 SLC18A2 PPP2R2D PPP2R2D CALY CALY DRD4 DRD4 CREB3L1 CREB3L1 GNG3 GNG3 PPP2R5B PPP2R5B PPP2R1B PPP2R1B KCNJ6 KCNJ6 CACNA1C CACNA1C GRIN2B GRIN2B KIF5A KIF5A PPP2R3C PPP2R3C PPP2R5C PPP2R5C GNB5 GNB5 PRKCB PRKCB ARRB2 ARRB2 PPP1R1B PPP1R1B PRKCA PRKCA CREB3L3 CREB3L3 PRKACA PRKACA GSK3A GSK3A CALM3 CALM3 PRKCG PRKCG KCNJ3 KCNJ3 SCN1A SCN1A PLCB1 PLCB1 PLCB4 PLCB4 COMT COMT ATF4 ATF4 ITPR2 ITPR2 ITPR1 ITPR1 GNAI2 GNAI2 ADCY5 ADCY5 PPP2R3A PPP2R3A GNB4 GNB4 CLOCK CLOCK GRIA2 GRIA2 SLC6A3 SLC6A3 MAPK9 MAPK9 ITPR3 ITPR3 MAPK14 MAPK14 PPP2R5D PPP2R5D GNGT1 GNGT1 GNG11 GNG11 CREB3L2 CREB3L2 PRKACG PRKACG GNG10 GNG10 CACNA1B CACNA1B MAOA MAOA MAOB MAOB MAPK8 MAPK8 PRKACB PRKACB ARRB1 ARRB1 CALML6 CALML6 GNB3 GNB3 KIF5B KIF5B GNAQ GNAQ CREB3 CREB3 SLC18A1 SLC18A1 DRD5 DRD5 GRIN2A GRIN2A MAPK12 MAPK12 ATF6B ATF6B GNAS GNAS GNGT2 GNGT2 GNG12 GNG12 DRD3 DRD3 GNG13 GNG13 LOC104003639 LOC104003639 PPP2CA PPP2CA ATF2 ATF2 CALML3 CALML3 PPP3CB PPP3CB GNG2 GNG2 DRD1 DRD1 ARNTL ARNTL LOC100609914 LOC100609914 GNB1 GNB1 PPP3CA PPP3CA PPP2R2A PPP2R2A PPP1CB PPP1CB GNG7 GNG7 DRD2 DRD2 MAPK10 MAPK10 GNAI1 GNAI1 CREB1 CREB1 CAMK2B CAMK2B PPP3CC PPP3CC MAPK11 MAPK11 GRIA3 GRIA3 CACNA1D CACNA1D GNAL GNAL CREB5 CREB5 PPP1CC PPP1CC FOS FOS KIF5C KIF5C PPP2R2B PPP2R2B PPP2R5A PPP2R5A CAMK2A CAMK2A GSK3B GSK3B AKT1 AKT1 CACNA1A CACNA1A PPP2R1A PPP2R1A GRIA4 GRIA4 GNB2 GNB2 PLCB3 PLCB3 AKT3 AKT3 PPP2CB PPP2CB GNAO1 GNAO1 AKT2 AKT2 GNG8 GNG8 DDC DDC PPP2R2C PPP2R2C GRIA1 GRIA1 KCNJ5 KCNJ5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CALML5Calmodulin like 5. (146 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
CALYCalcyon neuron specific vesicular protein. (218 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
KCNJ6KCNJ6 isoform 1. (323 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
PPP2R3CProtein phosphatase 2, regulatory subunit B'', gamma. (453 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
GNB5GNB5 isoform 1. (409 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ARRB2ARRB2 isoform 2. (430 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (271 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PPP2R3APPP2R3A isoform 1. (1150 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
CLOCKClock circadian regulator. (847 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2312 aa)
MAOAAmine oxidase. (527 aa)
MAOBAmine oxidase. (520 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ARRB1ARRB1 isoform 1. (418 aa)
CALML6Calmodulin like 6. (181 aa)
GNB3G protein subunit beta 3. (340 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
DRD5D(1B) dopamine receptor. (477 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
GNASGNAS isoform 19. (1042 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
DRD3D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity). (400 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
PPP2CAPPP2CB isoform 8. (309 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
LOC100609914PPP2R3B isoform 3. (475 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNALG protein subunit alpha L. (458 aa)
CREB5CREB5 isoform 1. (508 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (637 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
GNAO1G protein subunit alpha o1. (354 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DDCDopa decarboxylase. (489 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (469 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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