STRINGSTRING
MTOR MTOR PRKAA2 PRKAA2 NRAS NRAS CALML5 CALML5 HKDC1 HKDC1 HK1 HK1 HRAS HRAS PYGM PYGM RPS6KB2 RPS6KB2 INPPL1 INPPL1 CBL CBL GYS2 GYS2 SOCS2 SOCS2 PRKAB1 PRKAB1 FOXO1 FOXO1 IRS2 IRS2 PCK2 PCK2 SHC4 SHC4 SOCS1 SOCS1 PHKG2 PHKG2 PHKB PHKB SLC2A4 SLC2A4 G6PC3 G6PC3 RPS6KB1 RPS6KB1 GRB2 GRB2 RPTOR RPTOR FASN FASN MAP2K2 MAP2K2 PRKACA PRKACA PIK3R2 PIK3R2 LIPE LIPE CALM3 CALM3 HK2 HK2 G6PC2 G6PC2 PRKAG3 PRKAG3 IRS1 IRS1 PCK1 PCK1 MAPK1 MAPK1 CBLB CBLB PIK3CB PIK3CB PPARGC1A PPARGC1A HK3 HK3 MAPK9 MAPK9 FLOT1 FLOT1 PPP1R3A PPP1R3A IKBKB IKBKB PRKACG PRKACG FBP2 FBP2 FBP1 FBP1 PHKA2 PHKA2 ELK1 ELK1 MAPK8 MAPK8 GYS1 GYS1 PRKACB PRKACB GCK GCK PTPN1 PTPN1 SOS2 SOS2 CALML6 CALML6 PRKAR1A PRKAR1A CRKL CRKL EIF4E1B EIF4E1B PRKAA1 PRKAA1 SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 PKLR PKLR PPP1R3E PPP1R3E PRKAR2B PRKAR2B RPS6 RPS6 ENSPTRP00000062007 ENSPTRP00000062007 SOCS4 SOCS4 MAP2K1 MAP2K1 INSR INSR TSC1 TSC1 SHC3 SHC3 EXOC7 EXOC7 PIK3R3 PIK3R3 CALML3 CALML3 PYGL PYGL PPP1R3B PPP1R3B PRKCI PRKCI PHKG1-2 PHKG1-2 PPP1CB PPP1CB EIF4E EIF4E PRKAR1B PRKAR1B MAPK10 MAPK10 SH2B2 SH2B2 PTPRF PTPRF ACACA ACACA G6PC G6PC SREBF1 SREBF1 PYGB PYGB PIK3R1 PIK3R1 PPP1CC PPP1CC PRKAG2-2 PRKAG2-2 PRKAB2 PRKAB2 BRAF BRAF ACACB ACACB IRS4 IRS4 RHOQ RHOQ PPP1R3C PPP1R3C GSK3B GSK3B AKT1 AKT1 CRK CRK ARAF ARAF PHKA1 PHKA1 PPP1R3F PPP1R3F KRAS KRAS AKT3 AKT3 RHEB RHEB AKT2 AKT2 PPP1R3D PPP1R3D PRKAR2A PRKAR2A SOCS3 SOCS3 EIF4E2 EIF4E2 PRKAG1 PRKAG1 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
CALML5Calmodulin like 5. (146 aa)
HKDC1HKDC1 isoform 1. (917 aa)
HK1HK1 isoform 3. (921 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (1258 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
FOXO1FOXO1 isoform 1. (655 aa)
IRS2IRS2 isoform 1. (1340 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
PHKG2Phosphorylase kinase, gamma 2 (Testis); Belongs to the protein kinase superfamily. (532 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
SLC2A4SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
FASNFatty acid synthase. (2511 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
LIPELIPE isoform 1. (1076 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
HK2HK2 isoform 1. (917 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
HK3HK3 isoform 2. (923 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
PPP1R3APPP1R3A isoform 2. (1140 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GCKPhosphotransferase. (466 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML6Calmodulin like 6. (181 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (418 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSPTRP00000062007SH2B adapter protein 2-like. (570 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
TSC1TSC complex subunit 1. (1164 aa)
SHC3SHC3 isoform 2. (598 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (848 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
PHKG1-2Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
SH2B2Uncharacterized protein. (677 aa)
PTPRFProtein tyrosine phosphatase, receptor type, F. (1914 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
ACACBACACB isoform 2. (2458 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
RHOQRas homolog gene family, member Q. (205 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (798 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RHEBRHEB isoform 1. (184 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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