STRINGSTRING
NRAS NRAS ENSPTRP00000002048 ENSPTRP00000002048 PLA2G4A PLA2G4A CALML5 CALML5 HRAS HRAS FSHB FSHB CACNA1C CACNA1C MMP14 MMP14 ADCY4 ADCY4 PLA2G4E PLA2G4E PLA2G4D PLA2G4D ADCY9 ADCY9 PRKCB PRKCB PLD2 PLD2 MAP2K4 MAP2K4 MAPK7 MAPK7 MAP3K3 MAP3K3 PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 PRKACA PRKACA CALM3 CALM3 ADCY3 ADCY3 MAP3K2 MAP3K2 PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 ATF4 ATF4 ITPR2 ITPR2 ITPR1 ITPR1 PRKCD PRKCD ADCY5 ADCY5 GNRHR GNRHR HBEGF HBEGF MAPK9 MAPK9 ITPR3 ITPR3 MAPK14 MAPK14 ADCY1 ADCY1 GNRH1 GNRH1 PTK2B PTK2B PRKACG PRKACG ELK1 ELK1 CACNA1F CACNA1F MAPK8 MAPK8 PRKACB PRKACB PLD1 PLD1 SOS2 SOS2 CALML6 CALML6 MAP3K1 MAP3K1 GNAQ GNAQ SOS1 SOS1 MAPK3 MAPK3 MAPK12 MAPK12 GNAS GNAS LOC749464 LOC749464 ENSPTRP00000061486 ENSPTRP00000061486 MAP2K6 MAP2K6 ADCY7 ADCY7 LOC104003639 LOC104003639 MAP2K1 MAP2K1 CALML3 CALML3 EGFR EGFR MAPK10 MAPK10 MAP3K4 MAP3K4 CAMK2B CAMK2B GNA11 GNA11 MAPK11 MAPK11 CACNA1S CACNA1S CACNA1D CACNA1D SRC SRC ADCY8 ADCY8 CDC42 CDC42 LHB LHB CAMK2A CAMK2A ADCY2 ADCY2 KRAS KRAS EGR1 EGR1 PLCB3 PLCB3 MMP2 MMP2 PLA2G4F PLA2G4F ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
ENSPTRP00000002048LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. (91 aa)
PLA2G4APhospholipase A2. (749 aa)
CALML5Calmodulin like 5. (146 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLA2G4DPhospholipase A2. (818 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLD2Phospholipase. (933 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (619 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PLD1Phospholipase. (1074 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML6Calmodulin like 6. (181 aa)
MAP3K1MAP3K1 isoform 1. (1509 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
GNASGNAS isoform 19. (1042 aa)
LOC749464Phospholipase A2. (781 aa)
ENSPTRP00000061486Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
MAP3K4MAP3K4 isoform 5. (1601 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SRCTyrosine-protein kinase. (542 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (157 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PLA2G4FPhospholipase A2. (849 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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