STRINGSTRING
MAD2L2 MAD2L2 GNAI3 GNAI3 PGR PGR ANAPC5 ANAPC5 ADCY4 ADCY4 CCNB2 CCNB2 IGF1R IGF1R PKMYT1 PKMYT1 ADCY9 ADCY9 KIF22 KIF22 SPDYE4 SPDYE4 PRKACA PRKACA PIK3R2 PIK3R2 ADCY3 ADCY3 AURKA AURKA MAPK1 MAPK1 GNAI2 GNAI2 ADCY5 ADCY5 ANAPC13 ANAPC13 PIK3CB PIK3CB ANAPC4 ANAPC4 MAD2L1 MAD2L1 CCNA2 CCNA2 CCNB1 CCNB1 CDC23 CDC23 STK10 STK10 CPEB4 CPEB4 MAPK9 MAPK9 MAPK14 MAPK14 HSP90AB1 HSP90AB1 ADCY1 ADCY1 MOS MOS PRKACG PRKACG CDC26 CDC26 ANAPC2 ANAPC2 CPEB2 CPEB2 MAPK8 MAPK8 CDC25B CDC25B PRKACB PRKACB CDC25C CDC25C CK820_G0047526 CK820_G0047526 ENSPTRP00000047752 ENSPTRP00000047752 CDK1 CDK1 MAPK3 MAPK3 MAPK12 MAPK12 MAD1L1 MAD1L1 CK820_G0055452 CK820_G0055452 ENSPTRP00000060672 ENSPTRP00000060672 LOC742265 LOC742265 CDC16 CDC16 ADCY7 ADCY7 SPDYC SPDYC MAP2K1 MAP2K1 RPS6KA2 RPS6KA2 PIK3R3 PIK3R3 FZR1 FZR1 CCNB3 CCNB3 IGF1 IGF1 ANAPC10 ANAPC10 MAPK10 MAPK10 CCNA1 CCNA1 HSP90AA1 HSP90AA1 GNAI1 GNAI1 ANAPC1 ANAPC1 RPS6KA6 RPS6KA6 MAPK11 MAPK11 BUB1 BUB1 PIK3R1 PIK3R1 ADCY8 ADCY8 BRAF BRAF CPEB3 CPEB3 CPEB1 CPEB1 RPS6KA3 RPS6KA3 CDC27 CDC27 AKT1 AKT1 ARAF ARAF ADCY2 ADCY2 KRAS KRAS AKT3 AKT3 LOC107968084 LOC107968084 AKT2 AKT2 RPS6KA1 RPS6KA1 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
CCNB2CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
PKMYT1PKMYT1 isoform 8. (565 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
KIF22Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (665 aa)
SPDYE4Speedy/RINGO cell cycle regulator family member E4. (237 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
MAD2L1MAD2 mitotic arrest deficient-like 1. (205 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
CCNB1CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
CDC23Cell division cycle 23 homolog. (597 aa)
STK10Serine/threonine kinase 10. (968 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
CDC26Cell division cycle 26 homolog. (85 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1036 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CDC25BCell division cycle 25 homolog B. (580 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CDC25CCDC25C isoform 7. (508 aa)
CK820_G0047526SPDYE6 isoform 1. (376 aa)
ENSPTRP00000047752LOW QUALITY PROTEIN: speedy protein E2-like. (376 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
MAD1L1MAD1 mitotic arrest deficient-like 1. (718 aa)
CK820_G0055452SPDYE2 isoform 1. (376 aa)
ENSPTRP00000060672Speedy protein E1. (376 aa)
LOC742265SPDYE5 isoform 3. (336 aa)
CDC16Cell division cycle 16 homolog. (620 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (305 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
RPS6KA2Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
CCNB3CCNB3 isoform 4; Belongs to the cyclin family. (1396 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
CCNA1CCNA1 isoform 3; Belongs to the cyclin family. (421 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
ANAPC1ANAPC1 isoform 2. (1944 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
BUB1BUB1 isoform 1. (1091 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (716 aa)
CPEB1CPEB1 isoform 5. (626 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
CDC27Cell division cycle 27 homolog. (832 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC107968084Heat shock protein HSP 90-beta-like. (361 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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