STRINGSTRING
GNAI3 GNAI3 NRAS NRAS CREB3L4 CREB3L4 KCNJ9 KCNJ9 CALML5 CALML5 HRAS HRAS CREB3L1 CREB3L1 PGR PGR KCNJ6 KCNJ6 FKBP4 FKBP4 KRT18 KRT18 SP1 SP1 ADCY4 ADCY4 ESR2 ESR2 SHC4 SHC4 ADCY9 ADCY9 LOC454470 LOC454470 KRT16 KRT16 KRT24 KRT24 KRT25 KRT25 KRT27 KRT27 KRT28 KRT28 KRT10 KRT10 KRT12 KRT12 KRT20 KRT20 KRT23 KRT23 KRT33B KRT33B KRT37 KRT37 KRT38 KRT38 KRT32 KRT32 KRT36 KRT36 KRT40 KRT40 KRT35 KRT35 KRT13 KRT13 KRT15 KRT15 KRT9 KRT9 KRT14 KRT14 KRT17 KRT17 GRB2 GRB2 MAP2K2 MAP2K2 CREB3L3 CREB3L3 PRKACA PRKACA PIK3R2 PIK3R2 CALM3 CALM3 NCOA1 NCOA1 ADCY3 ADCY3 KCNJ3 KCNJ3 PLCB1 PLCB1 PLCB4 PLCB4 MMP9 MMP9 NCOA3 NCOA3 TFF1 TFF1 MAPK1 MAPK1 ATF4 ATF4 ITPR2 ITPR2 ITPR1 ITPR1 GNAI2 GNAI2 PRKCD PRKCD ADCY5 ADCY5 PIK3CB PIK3CB HBEGF HBEGF ITPR3 ITPR3 FKBP5 FKBP5 HSP90AB1 HSP90AB1 GRM1 GRM1 ESR1 ESR1 ADCY1 ADCY1 CREB3L2 CREB3L2 PRKACG PRKACG KRT19 KRT19 PRKACB PRKACB KRT39 KRT39 OPRM1 OPRM1 SOS2 SOS2 CALML6 CALML6 GABBR2 GABBR2 GNAQ GNAQ CREB3 CREB3 HSPA1L HSPA1L SHC1 SHC1 SOS1 SOS1 POMC POMC MAPK3 MAPK3 KRT41 KRT41 ATF6B ATF6B GNAS GNAS LOC745166 LOC745166 ENSPTRP00000060619 ENSPTRP00000060619 ADCY7 ADCY7 LOC104003639 LOC104003639 MAP2K1 MAP2K1 SHC3 SHC3 ATF2 ATF2 KRT31 KRT31 PIK3R3 PIK3R3 CALML3 CALML3 LOC457015 LOC457015 EGFR EGFR NCOA2 NCOA2 HSP90AA1 HSP90AA1 GNAI1 GNAI1 CREB1 CREB1 HSPA8 HSPA8 GABBR1 GABBR1 SRC SRC CTSD CTSD PIK3R1 PIK3R1 ADCY8 ADCY8 CREB5 CREB5 HSP90B1 HSP90B1 FOS FOS KRT33A KRT33A HSPA2 HSPA2 EBAG9 EBAG9 LOC748740 LOC748740 AKT1 AKT1 ADCY2 ADCY2 KRAS KRAS PLCB3 PLCB3 AKT3 AKT3 MMP2 MMP2 GNAO1 GNAO1 LOC107968084 LOC107968084 AKT2 AKT2 BCL2 BCL2 KRT34 KRT34 KCNJ5 KCNJ5 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
CALML5Calmodulin like 5. (146 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
KCNJ6KCNJ6 isoform 1. (323 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
KRT18KRT18 isoform 1; Belongs to the intermediate filament family. (430 aa)
SP1Sp1 transcription factor. (786 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
ESR2Estrogen receptor 2. (530 aa)
SHC4SHC adaptor protein 4. (630 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
LOC454470Keratin, type I cytoskeletal 17-like isoform X1. (437 aa)
KRT16KRT16 isoform 4; Belongs to the intermediate filament family. (485 aa)
KRT24KRT24 isoform 1; Belongs to the intermediate filament family. (525 aa)
KRT25Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity). (450 aa)
KRT27KRT27 isoform 1; Belongs to the intermediate filament family. (459 aa)
KRT28KRT28 isoform 1; Belongs to the intermediate filament family. (464 aa)
KRT10KRT10 isoform 1; Belongs to the intermediate filament family. (577 aa)
KRT12KRT12 isoform 1; Belongs to the intermediate filament family. (494 aa)
KRT20KRT20 isoform 1; Belongs to the intermediate filament family. (424 aa)
KRT23KRT23 isoform 7; Belongs to the intermediate filament family. (425 aa)
KRT33BKeratin, type I cuticular Ha3-I. (429 aa)
KRT37KRT37 isoform 1; Belongs to the intermediate filament family. (449 aa)
KRT38KRT38 isoform 1; Belongs to the intermediate filament family. (456 aa)
KRT32KRT32 isoform 1; Belongs to the intermediate filament family. (448 aa)
KRT36KRT36 isoform 2; Belongs to the intermediate filament family. (467 aa)
KRT40KRT40 isoform 1; Belongs to the intermediate filament family. (431 aa)
KRT35KRT35 isoform 1; Belongs to the intermediate filament family. (455 aa)
KRT13KRT13 isoform 5; Belongs to the intermediate filament family. (458 aa)
KRT15KRT15 isoform 2; Belongs to the intermediate filament family. (452 aa)
KRT9KRT9 isoform 1; Belongs to the intermediate filament family. (623 aa)
KRT14KRT14 isoform 1; Belongs to the intermediate filament family. (475 aa)
KRT17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (432 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
NCOA3Nuclear receptor coactivator. (1426 aa)
TFF1TFF1 isoform 1. (84 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
GRM1Glutamate receptor, metabotropic 1. (1194 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
KRT19KRT19 isoform 1; Belongs to the intermediate filament family. (400 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
KRT39KRT39 isoform 1; Belongs to the intermediate filament family. (491 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML6Calmodulin like 6. (181 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
HSPA1LHSPA1L isoform 1; Belongs to the heat shock protein 70 family. (641 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
POMCProopiomelanocortin. (268 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KRT41Type I keratin, acidic. (430 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
GNASGNAS isoform 19. (1042 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ENSPTRP00000060619LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (632 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SHC3SHC3 isoform 2. (598 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
KRT31Keratin, type I cuticular Ha1. (451 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC457015LOW QUALITY PROTEIN: endoplasmin-like. (448 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (969 aa)
SRCTyrosine-protein kinase. (542 aa)
CTSDT0155181 isoform 2; Belongs to the peptidase A1 family. (619 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CREB5CREB5 isoform 1. (508 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
KRT33AKeratin, type I cuticular Ha3-I. (405 aa)
HSPA2Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (258 aa)
LOC748740HSPA6 isoform 1; Belongs to the heat shock protein 70 family. (644 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
GNAO1G protein subunit alpha o1. (354 aa)
LOC107968084Heat shock protein HSP 90-beta-like. (361 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
KRT34Keratin, type I cuticular Ha4-like; Belongs to the intermediate filament family. (394 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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