STRINGSTRING
NRAS NRAS HRAS HRAS ELF5 ELF5 CCND2 CCND2 SOCS2 SOCS2 TNFSF11 TNFSF11 ESR2 ESR2 SHC4 SHC4 SOCS1 SOCS1 GRB2 GRB2 SOCS6 SOCS6 MAP2K2 MAP2K2 PIK3R2 PIK3R2 LHCGR LHCGR MAPK1 MAPK1 PIK3CB PIK3CB SLC2A2 SLC2A2 CSN2 CSN2 NFKB1 NFKB1 PRLR PRLR IRF1 IRF1 MAPK9 MAPK9 PRL PRL MAPK14 MAPK14 ESR1 ESR1 MAPK8 MAPK8 GCK GCK SOS2 SOS2 FOXO3 FOXO3 SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 RELA RELA MAPK12 MAPK12 SOCS5 SOCS5 SOCS4 SOCS4 MAP2K1 MAP2K1 SHC3 SHC3 PIK3R3 PIK3R3 CYP17A1 CYP17A1 MAPK10 MAPK10 MAPK11 MAPK11 SRC SRC PIK3R1 PIK3R1 FOS FOS LHB LHB GSK3B GSK3B CISH CISH AKT1 AKT1 KRAS KRAS AKT3 AKT3 CCND1 CCND1 AKT2 AKT2 STAT1 STAT1 STAT3 STAT3 SOCS3 SOCS3 SOCS7 SOCS7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
ELF5E74 like ETS transcription factor 5. (265 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
ESR2Estrogen receptor 2. (530 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CSN2Beta-casein; Important role in determination of the surface properties of the casein micelles. (225 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
IRF1Interferon regulatory factor. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PRLPRL isoform 1. (227 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GCKPhosphotransferase. (466 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
FOXO3FOXO3 isoform 1. (673 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (508 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (157 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SOCS7Suppressor of cytokine signaling 7. (580 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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