STRINGSTRING
NPPA NPPA PRKAA2 PRKAA2 GNAI3 GNAI3 NRAS NRAS NPR1 NPR1 KCNJ9 KCNJ9 PTGS2 PTGS2 PLA2G4A PLA2G4A RGS2 RGS2 CAMK1G CAMK1G CALML5 CALML5 CAMK1D CAMK1D HRAS HRAS KCNJ6 KCNJ6 CACNA1C CACNA1C PRKAB1 PRKAB1 CAMKK2 CAMKK2 ADCY4 ADCY4 PLA2G4E PLA2G4E PLA2G4D PLA2G4D MAP2K5 MAP2K5 ADCY9 ADCY9 PRKCB PRKCB CACNG3 CACNG3 MYLK3 MYLK3 PIK3R5 PIK3R5 MAPK7 MAPK7 PRKCA PRKCA CACNG5 CACNG5 CACNG1 CACNG1 KCNJ2 KCNJ2 EEF2 EEF2 MAP2K2 MAP2K2 PRKACA PRKACA CALM3 CALM3 KCNJ14 KCNJ14 PRKCG PRKCG CACNG7 CACNG7 CACNG6 CACNG6 ADCY3 ADCY3 KCNJ3 KCNJ3 PRKAG3 PRKAG3 OXT OXT PLCB1 PLCB1 PLCB4 PLCB4 MYLK2 MYLK2 MYL9 MYL9 MAPK1 MAPK1 CACNG2 CACNG2 ITPR2 ITPR2 ITPR1 ITPR1 OXTR OXTR RHOA RHOA GNAI2 GNAI2 ADCY5 ADCY5 CD38 CD38 GUCY1A1 GUCY1A1 MYLK4 MYLK4 ITPR3 ITPR3 ADCY1 ADCY1 NPR2 NPR2 PRKACG PRKACG ELK1 ELK1 CACNA1F CACNA1F PRKACB PRKACB CALML6 CALML6 PIK3CG PIK3CG CACNB2 CACNB2 PPP1R12A PPP1R12A NFATC2 NFATC2 PRKAA1 PRKAA1 GNAQ GNAQ CACNA2D3 CACNA2D3 MAPK3 MAPK3 CACNB4 CACNB4 ACTB ACTB GNAS GNAS CDKN1A CDKN1A LOC749464 LOC749464 ADCY7 ADCY7 LOC104003639 LOC104003639 MAP2K1 MAP2K1 ROCK2 ROCK2 GUCY1B1 GUCY1B1 LOC452727 LOC452727 CALML3 CALML3 RYR2 RYR2 PPP3CB PPP3CB PPP3CA PPP3CA PPP1CB PPP1CB EGFR EGFR CACNA2D1 CACNA2D1 GNAI1 GNAI1 CACNA2D4 CACNA2D4 CAMK2B CAMK2B KCNJ4 KCNJ4 GUCY1A2 GUCY1A2 PPP3CC PPP3CC CACNA1S CACNA1S CACNA1D CACNA1D SRC SRC CACNG4 CACNG4 ADCY8 ADCY8 PPP1CC PPP1CC PRKAG2-2 PRKAG2-2 FOS FOS PRKAB2 PRKAB2 KCNJ12 KCNJ12 PPP1R12B PPP1R12B CAMK2A CAMK2A ADCY2 ADCY2 KRAS KRAS ROCK1 ROCK1 PLCB3 PLCB3 CAMK1 CAMK1 CCND1 CCND1 CK820_G0056661 CK820_G0056661 CACNB3 CACNB3 NFATC3 NFATC3 RCAN1 RCAN1 GNAO1 GNAO1 NFATC4 NFATC4 MYL6 MYL6 EEF2K EEF2K CACNA2D2 CACNA2D2 MYLK MYLK PLA2G4F PLA2G4F MEF2C MEF2C RYR3 RYR3 RYR1 RYR1 KCNJ5 KCNJ5 PRKAG1 PRKAG1 PPP1R12C PPP1R12C ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPPANatriuretic peptide A. (153 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
NPR1Guanylate cyclase. (1061 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
PLA2G4APhospholipase A2. (749 aa)
RGS2Regulator of G-protein signaling 2, 24kDa. (211 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CALML5Calmodulin like 5. (146 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
KCNJ6KCNJ6 isoform 1. (323 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLA2G4DPhospholipase A2. (818 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
MYLK3MYLK3 isoform 1. (819 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (882 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MYLK2MYLK2 isoform 1. (596 aa)
MYL9Myosin, light chain 9, regulatory. (172 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
RHOARas homolog family member A. (193 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
CD38CD38 isoform 1. (300 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
NPR2Guanylate cyclase. (1047 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CALML6Calmodulin like 6. (181 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
NFATC2NFATC2 isoform 4. (938 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
CACNA2D3CACNA2D3 isoform 3. (1091 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
GNASGNAS isoform 19. (1042 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
LOC749464Phospholipase A2. (781 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (644 aa)
LOC452727Guanylate cyclase soluble subunit beta-2. (664 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RYR2RYR2 isoform 1. (4941 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
CACNA2D4CACNA2D4 isoform 6. (1154 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (765 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SRCTyrosine-protein kinase. (542 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
KCNJ12Potassium inwardly-rectifying channel, subfamily J, member 12. (433 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1043 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
CAMK1Calcium/calmodulin-dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CK820_G0056661KCNJ18 isoform 1. (433 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
RCAN1RCAN1 isoform 6. (276 aa)
GNAO1G protein subunit alpha o1. (354 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
MYL6MYL6 isoform 8. (233 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
MYLKMYLK isoform 12. (1919 aa)
PLA2G4FPhospholipase A2. (849 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
RYR3Ryanodine receptor 3. (4873 aa)
RYR1RYR1 isoform 3. (5037 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (793 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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