STRINGSTRING
MTOR MTOR PRKAA2 PRKAA2 SLC27A3 SLC27A3 CREB3L4 CREB3L4 AGT AGT CREB3L1 CREB3L1 PYGM PYGM RPS6KB2 RPS6KB2 GYS2 GYS2 PRKAB1 PRKAB1 MLXIP MLXIP FOXO1 FOXO1 TBC1D4 TBC1D4 IRS2 IRS2 PCK2 PCK2 NFKBIA NFKBIA PRKCB PRKCB SLC2A4 SLC2A4 G6PC3 G6PC3 RPS6KB1 RPS6KB1 CREB3L3 CREB3L3 PIK3R2 PIK3R2 NR1H2 NR1H2 SLC27A5 SLC27A5 PRKCE PRKCE G6PC2 G6PC2 PRKAG3 PRKAG3 IRS1 IRS1 PCK1 PCK1 PPARA PPARA PRKCD PRKCD PIK3CB PIK3CB SLC2A2 SLC2A2 PPARGC1A PPARGC1A NFKB1 NFKB1 SLC27A6 SLC27A6 MAPK9 MAPK9 GFPT2 GFPT2 MLXIPL MLXIPL PPP1R3A PPP1R3A CREB3L2 CREB3L2 IKBKB IKBKB MAPK8 MAPK8 GFPT1 GFPT1 GYS1 GYS1 PTPN1 PTPN1 CPT1B CPT1B PRKAA1 PRKAA1 SLC27A1 SLC27A1 CREB3 CREB3 RELA RELA PPP1R3E PPP1R3E PTPN11 PTPN11 INSR INSR RPS6KA2 RPS6KA2 OGA OGA PIK3R3 PIK3R3 PYGL PYGL PPP1R3B PPP1R3B TNFRSF1A TNFRSF1A IL6 IL6 PPP1CB PPP1CB PTPA-2 PTPA-2 MAPK10 MAPK10 CPT1A CPT1A CREB1 CREB1 RPS6KA6 RPS6KA6 PTPRF PTPRF CD36 CD36 G6PC G6PC SREBF1 SREBF1 PYGB PYGB PIK3R1 PIK3R1 CREB5 CREB5 PPARGC1B PPARGC1B PPP1CC PPP1CC SLC2A1 SLC2A1 PRKAG2-2 PRKAG2-2 PRKAB2 PRKAB2 NR1H3 NR1H3 PRKCQ PRKCQ ACACB ACACB PPP1R3C PPP1R3C GSK3B GSK3B RPS6KA3 RPS6KA3 AKT1 AKT1 SLC27A4 SLC27A4 AKT3 AKT3 AKT2 AKT2 RPS6KA1 RPS6KA1 PPP1R3D PPP1R3D STAT3 STAT3 SOCS3 SOCS3 PRKAG1 PRKAG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SLC27A3SLC27A3 isoform 3. (811 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit. (270 aa)
MLXIPMLX interacting protein. (919 aa)
FOXO1FOXO1 isoform 1. (655 aa)
TBC1D4TBC1D4 isoform 2. (1298 aa)
IRS2IRS2 isoform 1. (1340 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SLC2A4SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
NR1H2Nuclear receptor subfamily 1, group H, member 2. (461 aa)
SLC27A5SLC27A5 isoform 3. (690 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAG3PRKAG3 isoform 1. (489 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
SLC27A6SLC27A6 isoform 1. (619 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
MLXIPLMLX interacting protein like. (852 aa)
PPP1R3APPP1R3A isoform 2. (1140 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
CPT1BCPT1B isoform 2; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SLC27A1Solute carrier family 27 (Fatty acid transporter), member 1. (646 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
RPS6KA2Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
OGAMeningioma expressed antigen 5 (Hyaluronidase). (946 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (848 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
PTPA-2Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (373 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
PTPRFProtein tyrosine phosphatase, receptor type, F. (1914 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CREB5CREB5 isoform 1. (508 aa)
PPARGC1BPPARGC1B isoform 2. (1023 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
SLC2A1Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PRKAG2-2PRKAG2 isoform 10. (204 aa)
PRKAB2Protein kinase, AMP-activated, beta 2 non-catalytic subunit. (272 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa)
ACACBACACB isoform 2. (2458 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
SLC27A4Solute carrier family 27 (Fatty acid transporter), member 4. (646 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PRKAG1PRKAG1 isoform 12. (333 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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