STRINGSTRING
VCAM1 VCAM1 NRAS NRAS TGFB2 TGFB2 AGT AGT HRAS HRAS CDKN1B CDKN1B FOXO1 FOXO1 TGFB3 TGFB3 PRKCB PRKCB COL1A1 COL1A1 PRKCA PRKCA SMAD4 SMAD4 PIK3R2 PIK3R2 TGFB1 TGFB1 PRKCE PRKCE IL1A IL1A IL1B IL1B COL3A1 COL3A1 COL4A3 COL4A3 PLCB1 PLCB1 PLCB4 PLCB4 THBD THBD PLCG1 PLCG1 MAPK1 MAPK1 PRKCD PRKCD PIK3CB PIK3CB CXCL8 CXCL8 NFKB1 NFKB1 VEGFC VEGFC MAPK9 MAPK9 EDN1 EDN1 MAPK14 MAPK14 PIM1 PIM1 COL1A2 COL1A2 SERPINE1 SERPINE1 VEGFD VEGFD CDK4 CDK4 F3 F3 MAPK8 MAPK8 CYBB CYBB NOX4 NOX4 VEGFB VEGFB COL4A4 COL4A4 AGER AGER MAPK3 MAPK3 CASP3 CASP3 RELA RELA PLCE1 PLCE1 MAPK12 MAPK12 COL4A2 COL4A2 SMAD2 SMAD2 NOX1 NOX1 SELE SELE AGTR1 AGTR1 PIK3R3 PIK3R3 COL4A5 COL4A5 IL6 IL6 CCL2 CCL2 MAPK10 MAPK10 COL4A6 COL4A6 TGFBR1 TGFBR1 MAPK11 MAPK11 DIAPH1 DIAPH1 PLCG2 PLCG2 PIK3R1 PIK3R1 CDC42 CDC42 PLCD1 PLCD1 AKT1 AKT1 ICAM1 ICAM1 PLCD3 PLCD3 KRAS KRAS EGR1 EGR1 PLCB3 PLCB3 AKT3 AKT3 CCND1 CCND1 MMP2 MMP2 AKT2 AKT2 BCL2 BCL2 STAT1 STAT1 COL4A1 COL4A1 STAT3 STAT3 BAX BAX VEGFA VEGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCAM1Vascular cell adhesion molecule 1. (650 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
FOXO1FOXO1 isoform 1. (655 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
THBDTHBD isoform 1. (631 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
EDN1EDN1 isoform 1. (212 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NOX4NADPH oxidase 4. (578 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
COL4A4COL4A4 isoform 1. (1690 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NOX1NADPH oxidase 1. (564 aa)
SELESELE isoform 1. (612 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
CCL2C-C motif chemokine. (109 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DIAPH1DIAPH1 isoform 4. (1278 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
PLCD1Phosphoinositide phospholipase C. (779 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
PLCD3Phosphoinositide phospholipase C. (789 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
BAXBAX isoform 7. (123 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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