(53 nodes) Mineral absorption network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
	ATP7B	ATPase copper transporting beta. (1465 aa)
	TRPM7	Transient receptor potential cation channel, subfamily M, member 7. (1865 aa)
	HMOX2	Heme oxygenase 2. (370 aa)
	MT1F	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	LOC467981	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1A	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1G	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	MT1X	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	CYBRD1	Cytochrome b reductase 1. (286 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
	SLC5A1	Solute carrier family 5 member 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (664 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
	SLC26A6	Solute carrier family 26, member 6. (761 aa)
	TF	Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	SLC34A2	Solute carrier family 34 member 2. (690 aa)
	MT2A	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	STEAP1	Six transmembrane epithelial antigen of the prostate 1. (339 aa)
	SLC31A1	Solute carrier family 31 (Copper transporters), member 1. (190 aa)
	S100G-2	Protein S100; Belongs to the S-100 family. (79 aa)
	FTHL17	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
	SLC26A3	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (762 aa)
	TRPV6	Transient receptor potential cation channel subfamily V member 6. (765 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
	SLC6A19	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (419 aa)
	SLC26A9	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (887 aa)
	SLC39A4	SLC39A4 isoform 1. (649 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	FTL	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
	MT1H-2	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
	HEPH	HEPH isoform 1; Belongs to the multicopper oxidase family. (1212 aa)
	ATP7A	ATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
	CLCN2	Chloride channel protein. (898 aa)
	ATOX1	Antioxidant 1 copper chaperone. (73 aa)
	ATP1A3	ATP1A3 isoform 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1287 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
	SLC46A1	Solute carrier family 46 (Folate transporter), member 1. (459 aa)
	SLC11A2	SLC11A2 isoform 1. (590 aa)
	LOC101058101	Metallothionein 1/2. (52 aa)
	STEAP1B-2	STEAP1B isoform 1. (240 aa)
	SLC30A1	Solute carrier family 30 (Zinc transporter), member 1. (507 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
	STEAP2	Six transmembrane epithelial antigen of the prostate 2. (490 aa)
	VDR	Vitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	TRPM6	TRPM6 isoform 2. (2017 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOX1	ATP7A	ENSPTRP00000066520	ENSPTRP00000064175	Antioxidant 1 copper chaperone.	ATPase, Cu++ transporting, alpha polypeptide.	0.992
ATOX1	ATP7B	ENSPTRP00000066520	ENSPTRP00000010023	Antioxidant 1 copper chaperone.	ATPase copper transporting beta.	0.971
ATOX1	CLCN2	ENSPTRP00000066520	ENSPTRP00000066511	Antioxidant 1 copper chaperone.	Chloride channel protein.	0.646
ATOX1	SLC31A1	ENSPTRP00000066520	ENSPTRP00000036336	Antioxidant 1 copper chaperone.	Solute carrier family 31 (Copper transporters), member 1.	0.658
ATOX1	TRPM6	ENSPTRP00000066520	ENSPTRP00000088270	Antioxidant 1 copper chaperone.	TRPM6 isoform 2.	0.812
ATP1A1	ATP1A2	ENSPTRP00000090124	ENSPTRP00000081889	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.923
ATP1A1	ATP1A3	ENSPTRP00000090124	ENSPTRP00000068628	Sodium/potassium-transporting ATPase subunit alpha.	ATP1A3 isoform 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.929
ATP1A1	ATP1A4	ENSPTRP00000090124	ENSPTRP00000002591	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.905
ATP1A1	ATP1B1	ENSPTRP00000090124	ENSPTRP00000002750	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	0.994
ATP1A1	ATP1B2	ENSPTRP00000090124	ENSPTRP00000053141	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.978
ATP1A1	ATP1B3	ENSPTRP00000090124	ENSPTRP00000026646	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.986
ATP1A1	ATP1B4	ENSPTRP00000090124	ENSPTRP00000066466	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.954
ATP1A1	CLCN2	ENSPTRP00000090124	ENSPTRP00000066511	Sodium/potassium-transporting ATPase subunit alpha.	Chloride channel protein.	0.463
ATP1A2	ATP1A1	ENSPTRP00000081889	ENSPTRP00000090124	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.923
ATP1A2	ATP1A3	ENSPTRP00000081889	ENSPTRP00000068628	Sodium/potassium-transporting ATPase subunit alpha.	ATP1A3 isoform 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.958
ATP1A2	ATP1A4	ENSPTRP00000081889	ENSPTRP00000002591	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.923
ATP1A2	ATP1B1	ENSPTRP00000081889	ENSPTRP00000002750	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).	0.993
ATP1A2	ATP1B2	ENSPTRP00000081889	ENSPTRP00000053141	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.983
ATP1A2	ATP1B3	ENSPTRP00000081889	ENSPTRP00000026646	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.976
ATP1A2	ATP1B4	ENSPTRP00000081889	ENSPTRP00000066466	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.960