(56 nodes) Amphetamine addiction network (Pan troglodytes)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CREB3L4	cAMP responsive element binding protein 3-like 4. (395 aa)
	CALML5	Calmodulin like 5. (146 aa)
	SIRT1	SIRT1 isoform 2. (751 aa)
	SLC18A2	Solute carrier family 18 member A2. (514 aa)
	CREB3L1	cAMP responsive element binding protein 3-like 1. (519 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (461 aa)
	PRKACA	PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
	CALM3	Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	PDYN	PDYN isoform 1. (254 aa)
	ATF4	Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
	STX1A	STX1A isoform 3; Belongs to the syntaxin family. (288 aa)
	CREB3L2	cAMP responsive element binding protein 3-like 2. (520 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	MAOA	Amine oxidase. (527 aa)
	MAOB	Amine oxidase. (520 aa)
	GRIN3A	GRIN3A isoform 1. (1115 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	CALML6	Calmodulin like 6. (181 aa)
	CREB3	cAMP responsive element binding protein 3. (371 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
	ARC	Activity-regulated cytoskeleton-associated protein. (396 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	GRIN2A	Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
	ATF6B	Activating transcription factor 6 beta. (711 aa)
	GNAS	GNAS isoform 19. (1042 aa)
	LOC104003639	Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (526 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
	GRIN2C	GRIN2C isoform 4. (1240 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (666 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (521 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
	CREB5	CREB5 isoform 1. (508 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	DDC	Dopa decarboxylase. (489 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CACNA1C	ENSPTRP00000026385	ENSPTRP00000007742	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.632
ADCY5	CALM3	ENSPTRP00000026385	ENSPTRP00000019197	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family.	0.777
ADCY5	CALML3	ENSPTRP00000026385	ENSPTRP00000064433	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.787
ADCY5	CALML5	ENSPTRP00000026385	ENSPTRP00000003820	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.788
ADCY5	CALML6	ENSPTRP00000026385	ENSPTRP00000043977	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.786
ADCY5	CAMK2A	ENSPTRP00000026385	ENSPTRP00000080192	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.911
ADCY5	CAMK2B	ENSPTRP00000026385	ENSPTRP00000073307	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.904
ADCY5	GNAS	ENSPTRP00000026385	ENSPTRP00000059419	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS isoform 19.	0.982
ADCY5	LOC104003639	ENSPTRP00000026385	ENSPTRP00000063078	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(s) subunit alpha.	0.902
ADCY5	PRKACA	ENSPTRP00000026385	ENSPTRP00000018062	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.935
ADCY5	PRKACB	ENSPTRP00000026385	ENSPTRP00000042330	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.931
ADCY5	PRKACG	ENSPTRP00000026385	ENSPTRP00000035898	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.931
ADCY5	PRKCA	ENSPTRP00000026385	ENSPTRP00000016236	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.822
ADCY5	PRKCB	ENSPTRP00000026385	ENSPTRP00000013479	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.700
ADCY5	PRKCG	ENSPTRP00000026385	ENSPTRP00000019651	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.678
ARC	CAMK2A	ENSPTRP00000053027	ENSPTRP00000080192	Activity-regulated cytoskeleton-associated protein.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.566
ARC	CAMK2B	ENSPTRP00000053027	ENSPTRP00000073307	Activity-regulated cytoskeleton-associated protein.	Calcium/calmodulin dependent protein kinase II beta.	0.659
ARC	CREB1	ENSPTRP00000053027	ENSPTRP00000072951	Activity-regulated cytoskeleton-associated protein.	cAMP responsive element binding protein 1.	0.580
ARC	FOS	ENSPTRP00000053027	ENSPTRP00000078496	Activity-regulated cytoskeleton-associated protein.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.633
ARC	FOSB	ENSPTRP00000053027	ENSPTRP00000085853	Activity-regulated cytoskeleton-associated protein.	FosB proto-oncogene, AP-1 transcription factor subunit.	0.466