STRINGSTRING
GNAI3 GNAI3 NRAS NRAS H3-4 H3-4 CREB3L4 CREB3L4 LOC469702 LOC469702 GNG4 GNG4 CALML5 CALML5 H2AFY2 H2AFY2 SLC18A2 SLC18A2 HRAS HRAS CREB3L1 CREB3L1 GNG3 GNG3 H2AFX H2AFX GRIN2B GRIN2B LOC457262 LOC457262 H2AC7 H2AC7 CAMKK2 CAMKK2 SHC4 SHC4 GNB5 GNB5 ADORA2B ADORA2B PPP1R1B PPP1R1B HDAC5 HDAC5 GRB2 GRB2 CREB3L3 CREB3L3 PRKACA PRKACA CALM3 CALM3 HAT1 HAT1 HIST1H3A HIST1H3A PDYN PDYN MAPK1 MAPK1 ADORA2A ADORA2A ATF4 ATF4 HDAC10 HDAC10 GNAI2 GNAI2 ADCY5 ADCY5 GNB4 GNB4 H2AZ1 H2AZ1 SLC6A3 SLC6A3 H2AFY H2AFY HDAC3 HDAC3 HIST1H2AA HIST1H2AA HIST1H2BA HIST1H2BA LOC748495 LOC748495 HIST1H2BB HIST1H2BB LOC462501 LOC462501 HIST1H1E HIST1H1E LOC462506 LOC462506 H2AC6 H2AC6 LOC112209457 LOC112209457 H2BC11 H2BC11 H2AC14 H2AC14 HDAC9 HDAC9 NPY NPY H2AFV H2AFV GNGT1 GNGT1 GNG11 GNG11 CREB3L2 CREB3L2 CRH CRH PKIA PKIA PRKACG PRKACG GNG10 GNG10 MAOA MAOA MAOB MAOB HDAC6 HDAC6 LOC107971249 LOC107971249 GRIN3A GRIN3A SLC29A2 SLC29A2 PRKACB PRKACB SLC29A3 SLC29A3 SOS2 SOS2 CALML6 CALML6 GNB3 GNB3 H3C13 H3C13 CREB3 CREB3 HDAC2 HDAC2 H2BC13 H2BC13 SHC1 SHC1 HIST2H2AB HIST2H2AB H2BC21 H2BC21 H2AW H2AW H2BC18 H2BC18 SOS1 SOS1 SLC18A1 SLC18A1 MAPK3 MAPK3 GRIN2A GRIN2A ATF6B ATF6B GNAS GNAS LOC473712 LOC473712 BDNF BDNF H2AJ H2AJ GNGT2 GNGT2 LOC473843 LOC473843 GNG12 GNG12 LOC462508 LOC462508 GNG13 GNG13 LOC104003639 LOC104003639 MAP2K1 MAP2K1 SHC3 SHC3 ATF2 ATF2 CALML3 CALML3 GNG2 GNG2 DRD1 DRD1 GNB1 GNB1 LOC746468 LOC746468 PPP1CB PPP1CB GNG7 GNG7 DRD2 DRD2 LOC471880 LOC471880 SLC29A1 SLC29A1 H2BC9 H2BC9 H2BC5 H2BC5 GNAI1 GNAI1 GRIN2C GRIN2C CREB1 CREB1 HDAC4 HDAC4 HDAC1 HDAC1 NTRK2 NTRK2 CREB5 CREB5 PPP1CC PPP1CC BRAF BRAF HDAC8 HDAC8 ARAF ARAF KRAS KRAS HDAC11 HDAC11 GNB2 GNB2 H2BC14 H2BC14 FOSB FOSB LOC462509 LOC462509 GNAO1 GNAO1 H2BU1 H2BU1 HDAC7 HDAC7 GNG8 GNG8 DDC DDC CAMKK1 CAMKK1 H2AC20 H2AC20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
H3-4HIST3H3 isoform 1. (136 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
LOC469702Histone H2B type 3-A. (126 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CALML5Calmodulin like 5. (146 aa)
H2AFY2H2AFY2 isoform 1. (372 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
H2AFXH2AFX isoform 1. (143 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
LOC457262HIST1H4A isoform 1. (103 aa)
H2AC7Histone H2A type 1-D. (130 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
SHC4SHC adaptor protein 4. (630 aa)
GNB5GNB5 isoform 1. (409 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
HIST1H3AH3F3B isoform 13. (136 aa)
PDYNPDYN isoform 1. (254 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
HDAC10Histone deacetylase 10. (669 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
H2AZ1H2AFZ isoform 3. (128 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
H2AFYH2AFY isoform 4. (372 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HIST1H2AAHIST1H2AA isoform 1. (131 aa)
HIST1H2BAHIST1H2BA isoform 1. (127 aa)
LOC748495HIST1H2AB isoform 1. (130 aa)
HIST1H2BBHIST1H2BB isoform 1. (126 aa)
LOC462501HIST1H2BK isoform 1. (126 aa)
HIST1H1EHistone cluster 1 H1 family member e. (219 aa)
LOC462506Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6HIST1H2AC isoform 1. (130 aa)
LOC112209457HIST1H3A isoform 1. (136 aa)
H2BC11HIST1H2BJ isoform 1. (126 aa)
H2AC14HIST1H2AJ isoform 1. (128 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
NPYNeuropeptide Y. (97 aa)
H2AFVH2AFV isoform 6. (128 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
CRHCorticotropin releasing hormone. (196 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
MAOAAmine oxidase. (527 aa)
MAOBAmine oxidase. (520 aa)
HDAC6Histone deacetylase 6. (146 aa)
LOC107971249Histone H2A; Belongs to the histone H2A family. (115 aa)
GRIN3AGRIN3A isoform 1. (1115 aa)
SLC29A2Solute carrier family 29 (Nucleoside transporters), member 2. (456 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SLC29A3Solute carrier family 29 (Nucleoside transporters), member 3. (475 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML6Calmodulin like 6. (181 aa)
GNB3G protein subunit beta 3. (340 aa)
H3C13HIST2H3A isoform 1. (136 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
HIST2H2ABHIST2H2AB isoform 1. (130 aa)
H2BC21HIST2H2BE isoform 1. (126 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (147 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
GNASGNAS isoform 19. (1042 aa)
LOC473712H2BFWT isoform 1. (175 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
H2AJH2AFJ isoform 2. (129 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
LOC473843Histone H2B type W-T-like. (153 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC462508Histone H2B type 1-N. (167 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SHC3SHC3 isoform 2. (598 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
LOC746468HIST2H2AA3 isoform 1. (130 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
LOC471880Histone H2B; Belongs to the histone H2B family. (126 aa)
SLC29A1Solute carrier family 29 (Nucleoside transporters), member 1. (523 aa)
H2BC9HIST1H2BH isoform 1. (126 aa)
H2BC5HIST1H2BD isoform 1. (126 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
GRIN2CGRIN2C isoform 4. (1240 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
CREB5CREB5 isoform 1. (508 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (396 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
HDAC11HDAC11 isoform 14. (374 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
H2BC14HIST1H2BM isoform 1. (126 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
LOC462509HIST1H2BO isoform 1. (126 aa)
GNAO1G protein subunit alpha o1. (354 aa)
H2BU1HIST3H2BB isoform 1. (126 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DDCDopa decarboxylase. (489 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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