STRINGSTRING
WASF2 WASF2 ENSPTRP00000000715 ENSPTRP00000000715 PKN2 PKN2 IL10 IL10 NLRP3 NLRP3 DOCK1 DOCK1 TRAF6 TRAF6 IL18 IL18 IRAK4 IRAK4 ITGA5 ITGA5 TBK1 TBK1 NFKBIA NFKBIA MAP2K4 MAP2K4 PIP5K1C PIP5K1C MAP2K2 MAP2K2 VAV1 VAV1 PIK3R2 PIK3R2 ARHGEF1 ARHGEF1 ZAP70 ZAP70 IL1B IL1B ITGA4 ITGA4 PLCG1 PLCG1 ELMO2 ELMO2 MAPK1 MAPK1 RHOA RHOA PIK3CB PIK3CB CXCL8 CXCL8 NFKB1 NFKB1 IL2 IL2 ARHGEF28 ARHGEF28 LCP2 LCP2 MAPK9 MAPK9 MAPK14 MAPK14 TAB2 TAB2 WIPF3 WIPF3 WASL WASL ACTR3B ACTR3B PTK2B PTK2B IKBKB IKBKB IFNB1 IFNB1 TLR4 TLR4 MAPK8 MAPK8 FCGR2A FCGR2A NLRC4 NLRC4 CRKL CRKL NFATC2 NFATC2 RHOG RHOG GNAQ GNAQ MAPK3 MAPK3 RELA RELA CD4 CD4 MAPK12 MAPK12 LAT LAT MAP3K7 MAP3K7 ARHGEF12 ARHGEF12 ACTB ACTB CD8B CD8B ENSPTRP00000061486 ENSPTRP00000061486 MYD88 MYD88 MAP2K6 MAP2K6 MAP2K1 MAP2K1 RPS6KA2 RPS6KA2 ROCK2 ROCK2 PIK3R3 PIK3R3 WIPF2 WIPF2 ACTR3C ACTR3C CD8A CD8A WAS WAS IL6 IL6 CCL2 CCL2 ARF6 ARF6 ITGB1 ITGB1 MAPK10 MAPK10 PIP5K1B PIP5K1B ELMO1 ELMO1 RPS6KA6 RPS6KA6 PIP5K1A PIP5K1A MAPK11 MAPK11 WIPF1 WIPF1 GIT2 GIT2 LOC100610002 LOC100610002 SRC SRC PIK3R1 PIK3R1 CDC42 CDC42 PKN1 PKN1 FOS FOS CASP1 CASP1 LIMK1-2 LIMK1-2 BCAR1 BCAR1 GSK3B GSK3B RPS6KA3 RPS6KA3 BV7-9 BV7-9 AKT1 AKT1 CRK CRK VAV2 VAV2 CHUK CHUK SKAP2 SKAP2 ROCK1 ROCK1 AKT3 AKT3 NFATC3 NFATC3 AKT2 AKT2 VAV3 VAV3 FYB1 FYB1 RPS6KA1 RPS6KA1 ACTR2 ACTR2 TAB1 TAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WASF2WAS protein family, member 2. (498 aa)
ENSPTRP00000000715Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
PKN2Protein kinase N2. (984 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
NLRP3NLRP3 isoform 2. (1025 aa)
DOCK1DOCK1 isoform 1; Belongs to the DOCK family. (1854 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
TBK1TANK-binding kinase 1. (729 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RHOARas homolog family member A. (193 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ARHGEF28ARHGEF28 isoform 4. (1731 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
WIPF3WAS/WASL interacting protein family member 3. (483 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ACTR3BARP3 actin-related protein 3 homolog B; Belongs to the actin family. (418 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
IFNB1Interferon beta 1. (187 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
NFATC2NFATC2 isoform 4. (938 aa)
RHOGRas homolog gene family, member G (Rho G). (191 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
LATLinker for activation of T cells. (268 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
CD8BCD8B isoform 3. (243 aa)
ENSPTRP00000061486Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
RPS6KA2Ribosomal protein S6 kinase alpha-2 isoform X1. (758 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
WIPF2WAS/WASL interacting protein family, member 2. (440 aa)
ACTR3CActin-related protein 3C isoform X1. (239 aa)
CD8ACD8A isoform 1. (235 aa)
WASWAS isoform 1. (502 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
CCL2C-C motif chemokine. (109 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
ELMO1Engulfment and cell motility 1. (769 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
WIPF1WAS/WASL interacting protein family, member 1. (554 aa)
GIT2G protein-coupled receptor kinase interacting ArfGAP 2. (760 aa)
LOC100610002IKBKG isoform 9. (401 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
PKN1PKN1 isoform 2. (948 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
BV7-9TRBV7-9 isoform 1. (155 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
SKAP2Src kinase associated phosphoprotein 2. (359 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VAV3VAV3 isoform 2. (927 aa)
FYB1FYB1 isoform 3. (839 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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