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JAK1 JAK1 GNAI3 GNAI3 LAMC1 LAMC1 LAMC2 LAMC2 IL10 IL10 TGFB2 TGFB2 PPIF PPIF TRAF6 TRAF6 BIRC2 BIRC2 IRAK4 IRAK4 IFNG IFNG NFKBIA NFKBIA TGFB3 TGFB3 CIITA CIITA SOCS1 SOCS1 PIK3R5 PIK3R5 LAMA3 LAMA3 TGFB1 TGFB1 CASP8 CASP8 BCL2L1 BCL2L1 MAPK1 MAPK1 CCR5 CCR5 LAMB2 LAMB2 GNAI2 GNAI2 NFKB1 NFKB1 TLR2 TLR2 IL12B IL12B MAPK9 MAPK9 PATR-DRA PATR-DRA HLA-DQB1 HLA-DQB1 PATR-DOB PATR-DOB PATR-DMB PATR-DMB MAMU-DMA MAMU-DMA HLA-DOA HLA-DOA HLA-DPA1 HLA-DPA1 MAPK14 MAPK14 LAMA2 LAMA2 TAB2 TAB2 CYCS CYCS LAMB4 LAMB4 IKBKB IKBKB TLR4 TLR4 LAMB3 LAMB3 MAPK8 MAPK8 IL10RB IL10RB PIK3CG PIK3CG TYK2 TYK2 IFNGR1 IFNGR1 HSPA1L HSPA1L MAPK3 MAPK3 CASP3 CASP3 RELA RELA LOC104006793 LOC104006793 HLA-DQA1 HLA-DQA1 MAPK12 MAPK12 HLA-DPB1 HLA-DPB1 MAP3K7 MAP3K7 NFKBIB NFKBIB PATR-DQB1 PATR-DQB1 LOC745166 LOC745166 ENSPTRP00000060619 ENSPTRP00000060619 ENSPTRP00000061486 ENSPTRP00000061486 MYD88 MYD88 MAP2K6 MAP2K6 LOC107972317 LOC107972317 TNFRSF1A TNFRSF1A ALOX5 ALOX5 CD40 CD40 LAMB1 LAMB1 ITGB1 ITGB1 MAPK10 MAPK10 GNAI1 GNAI1 XIAP XIAP MAPK11 MAPK11 HSPA8 HSPA8 LOC100610002 LOC100610002 IRGM IRGM CD40LG CD40LG HSPA2 HSPA2 LOC748740 LOC748740 LOC104002760 LOC104002760 BIRC7 BIRC7 AKT1 AKT1 LY96 LY96 CHUK CHUK IL10RA IL10RA LAMA1 LAMA1 AKT3 AKT3 ITGA6 ITGA6 GNAO1 GNAO1 LAMC3 LAMC3 LAMA5 LAMA5 CASP9 CASP9 AKT2 AKT2 BCL2 BCL2 BIRC3 BIRC3 STAT1 STAT1 STAT3 STAT3 IFNGR2-2 IFNGR2-2 LAMA4 LAMA4 TAB1 TAB1 LOC742456 LOC742456 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1154 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
LAMC2LAMC2 isoform 1. (1193 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (882 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PATR-DRAMHC class II protein; Belongs to the MHC class II family. (254 aa)
HLA-DQB1HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa)
PATR-DOBPatr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa)
PATR-DMBHLA-DMB isoform 5. (263 aa)
MAMU-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
LAMB4LAMB4 isoform 2. (1761 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL10RBInterleukin 10 receptor, beta. (325 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
HSPA1LHSPA1L isoform 1; Belongs to the heat shock protein 70 family. (641 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
LOC104006793HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa)
HLA-DQA1HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKBIBNFKB inhibitor beta. (270 aa)
PATR-DQB1HLA-DRB1 isoform 1. (271 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ENSPTRP00000060619LOW QUALITY PROTEIN: heat shock 70 kDa protein 6. (632 aa)
ENSPTRP00000061486Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
LOC107972317Cytochrome c-like. (102 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
ALOX5ALOX5 isoform 2. (785 aa)
CD40CD40 molecule, TNF receptor superfamily member 5. (277 aa)
LAMB1LAMB1 isoform 5. (1789 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
XIAPBaculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (497 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
LOC100610002IKBKG isoform 9. (401 aa)
IRGMImmunity-related GTPase M. (214 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
HSPA2Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa)
LOC748740HSPA6 isoform 1; Belongs to the heat shock protein 70 family. (644 aa)
LOC104002760Cytochrome c. (110 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
LY96Lymphocyte antigen 96. (160 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
GNAO1G protein subunit alpha o1. (354 aa)
LAMC3Laminin subunit gamma 3. (1580 aa)
LAMA5Laminin, alpha 5. (2203 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BIRC3Baculoviral IAP repeat containing 3. (610 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
IFNGR2-2IFNGR2 isoform 6. (302 aa)
LAMA4LAMA4 isoform 3. (1823 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
LOC742456Cytochrome c-like. (105 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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