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| | MASP2 | Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa) |
| | PTAFR | Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | FCGR1A | FCGR1A isoform 2. (373 aa) |
| | SELP | SELP isoform 2. (830 aa) |
| | CFH | CFH isoform 2. (1231 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | C3AR1 | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (482 aa) |
| | KRT18 | KRT18 isoform 1; Belongs to the intermediate filament family. (430 aa) |
| | Pt-FCAR | FCAR isoform 1. (286 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | LOC454470 | Keratin, type I cytoskeletal 17-like isoform X1. (437 aa) |
| | KRT16 | KRT16 isoform 4; Belongs to the intermediate filament family. (485 aa) |
| | KRT24 | KRT24 isoform 1; Belongs to the intermediate filament family. (525 aa) |
| | KRT25 | Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity). (450 aa) |
| | KRT27 | KRT27 isoform 1; Belongs to the intermediate filament family. (459 aa) |
| | KRT28 | KRT28 isoform 1; Belongs to the intermediate filament family. (464 aa) |
| | KRT10 | KRT10 isoform 1; Belongs to the intermediate filament family. (577 aa) |
| | KRT12 | KRT12 isoform 1; Belongs to the intermediate filament family. (494 aa) |
| | KRT20 | KRT20 isoform 1; Belongs to the intermediate filament family. (424 aa) |
| | KRT23 | KRT23 isoform 7; Belongs to the intermediate filament family. (425 aa) |
| | KRT33B | Keratin, type I cuticular Ha3-I. (429 aa) |
| | KRT37 | KRT37 isoform 1; Belongs to the intermediate filament family. (449 aa) |
| | KRT38 | KRT38 isoform 1; Belongs to the intermediate filament family. (456 aa) |
| | KRT32 | KRT32 isoform 1; Belongs to the intermediate filament family. (448 aa) |
| | KRT36 | KRT36 isoform 2; Belongs to the intermediate filament family. (467 aa) |
| | KRT40 | KRT40 isoform 1; Belongs to the intermediate filament family. (431 aa) |
| | KRT35 | KRT35 isoform 1; Belongs to the intermediate filament family. (455 aa) |
| | KRT13 | KRT13 isoform 5; Belongs to the intermediate filament family. (458 aa) |
| | KRT15 | KRT15 isoform 2; Belongs to the intermediate filament family. (452 aa) |
| | KRT9 | KRT9 isoform 1; Belongs to the intermediate filament family. (623 aa) |
| | KRT14 | KRT14 isoform 1; Belongs to the intermediate filament family. (475 aa) |
| | KRT17 | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (432 aa) |
| | DSG1 | DSG1 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1048 aa) |
| | C3 | Complement component 3. (465 aa) |
| | FPR1 | fMet-Leu-Phe receptor; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity). (350 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa) |
| | PATR-DRA | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | HLA-DQB1 | HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa) |
| | PATR-DOB | Patr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa) |
| | PATR-DMB | HLA-DMB isoform 5. (263 aa) |
| | MAMU-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | PLG | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa) |
| | DEFB1 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa) |
| | DEFA4 | Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity). (97 aa) |
| | DEFB103A | Beta-defensin 103A; Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria; Belongs to the beta-defensin family. (67 aa) |
| | C5 | Complement C5. (1676 aa) |
| | FCGR2A | Low affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa) |
| | KRT19 | KRT19 isoform 1; Belongs to the intermediate filament family. (400 aa) |
| | KRT39 | KRT39 isoform 1; Belongs to the intermediate filament family. (491 aa) |
| | ITGAL | ITGAL isoform 4. (344 aa) |
| | CFI | Complement factor I; Belongs to the peptidase S1 family. (591 aa) |
| | C5AR1 | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (351 aa) |
| | LOC104006793 | HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa) |
| | KRT41 | Type I keratin, acidic. (430 aa) |
| | C1R | Complement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (719 aa) |
| | C1S | Complement component 1, s subcomponent; Belongs to the peptidase S1 family. (780 aa) |
| | HLA-DQA1 | HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa) |
| | HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | PATR-DQB1 | HLA-DRB1 isoform 1. (271 aa) |
| | C1QA | Complement C1q A chain. (245 aa) |
| | FPR3 | N-formyl peptide receptor 3; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. (353 aa) |
| | KRT31 | Keratin, type I cuticular Ha1. (451 aa) |
| | LOC462577 | C4B isoform 1. (1750 aa) |
| | MBL2 | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (270 aa) |
| | DEFA5 | Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family. (94 aa) |
| | DEFB4A | Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells; Belongs to the beta-defensin family. LAP/TAP subfamily. (64 aa) |
| | C2 | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity). (1112 aa) |
| | C1QB | C1QB isoform 2. (253 aa) |
| | LOC107973208 | Neutrophil defensin 1; Has antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (By similarity); Belongs to the alpha-defensin family. (94 aa) |
| | KRT33A | Keratin, type I cuticular Ha3-I. (405 aa) |
| | BV7-9 | TRBV7-9 isoform 1. (155 aa) |
| | FGG | Fibrinogen gamma chain. (453 aa) |
| | ICAM1 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa) |
| | MASP1 | Mannan binding lectin serine peptidase 1. (699 aa) |
| | LOC745350 | FCGR3A isoform 2. (233 aa) |
| | DEFA6 | Defensin-6; Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria; Belongs to the alpha-defensin family. (100 aa) |
| | ITGB2 | Integrin beta. (863 aa) |
| | KRT34 | Keratin, type I cuticular Ha4-like; Belongs to the intermediate filament family. (394 aa) |
