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| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | BCL10 | B-cell CLL/lymphoma 10. (316 aa) |
| | FCGR1A | FCGR1A isoform 2. (373 aa) |
| | CTSS | CTSS isoform 1; Belongs to the peptidase C1 family. (331 aa) |
| | RFX5 | Regulatory factor X, 5 (Influences HLA class II expression). (616 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CALML5 | Calmodulin like 5. (146 aa) |
| | MRC1 | Mannose receptor C-type 1. (1456 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (219 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (227 aa) |
| | IL23A | Interleukin 23 subunit alpha. (189 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa) |
| | RFXAP | Regulatory factor X associated protein. (272 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | ATP6V0C | V-type H+-transporting ATPase 16kDa proteolipid subunit. (155 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1131 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa) |
| | MRC2 | Mannose receptor, C type 2. (1479 aa) |
| | MALT1 | Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa) |
| | C3 | Complement component 3. (465 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | CALM3 | Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa) |
| | SPHK2 | Sphingosine kinase 2. (255 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | CASP8 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | EP300 | E1A binding protein p300. (2175 aa) |
| | IRAK2 | Interleukin-1 receptor-associated kinase 2. (625 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (216 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | PATR-DRA | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | HLA-DQB1 | HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa) |
| | PATR-DOB | Patr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa) |
| | PATR-DMB | HLA-DMB isoform 5. (263 aa) |
| | MAMU-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | IFNA21 | Interferon alpha 21. (189 aa) |
| | IFNA2 | IFNA2 isoform 1. (170 aa) |
| | IFNA5 | Interferon alpha 5. (189 aa) |
| | TLR4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (470 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | FCGR2A | Low affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (By similarity). (318 aa) |
| | IL10RB | Interleukin 10 receptor, beta. (325 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | TRADD | TNFRSF1A-associated via death domain. (312 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (489 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (112 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CR1L | CR1L isoform 2. (569 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) |
| | LOC104006793 | HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa) |
| | CLEC4M | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (445 aa) |
| | HLA-DQA1 | HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (370 aa) |
| | HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa) |
| | CD209L2 | CD209 isoform 3. (256 aa) |
| | PATR-DQB1 | HLA-DRB1 isoform 1. (271 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | HSPD1 | Heat shock 60kDa protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family. (598 aa) |
| | CASP10 | CASP10 isoform 4; Belongs to the peptidase C14A family. (523 aa) |
| | TIRAP | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (235 aa) |
| | LAMP1 | Lysosome-associated membrane glycoprotein 1. (465 aa) |
| | LOC107972317 | Cytochrome c-like. (102 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (526 aa) |
| | LSP1 | LSP1 isoform 9. (466 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A. (455 aa) |
| | CR1 | CR1 isoform 2. (2039 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (384 aa) |
| | IFNA17 | IFNA17 isoform 1. (189 aa) |
| | CD209 | CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (256 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (666 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (521 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | EEA1 | Early endosome antigen 1. (1411 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | CTSD | T0155181 isoform 2; Belongs to the peptidase A1 family. (619 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | RAB5C | T0136450 isoform 1. (249 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa) |
| | ATP6V0A4-2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa) |
| | CK820_G0014527 | IFNA13 isoform 2. (198 aa) |
| | PLA2R1 | PLA2R1 isoform 2. (1466 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (347 aa) |
| | LOC104002760 | Cytochrome c. (110 aa) |
| | CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma. (150 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | TLR9 | T0016681 isoform 1. (1033 aa) |
| | VDR | Vitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa) |
| | IFNA8 | Interferon alpha 8. (189 aa) |
| | LOC745350 | FCGR3A isoform 2. (233 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (578 aa) |
| | LOC741747 | IFNA7 isoform 1. (189 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (411 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa) |
| | LOC742651 | IFNA1 isoform 1. (195 aa) |
| | CASP9 | CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | ITGB2 | Integrin beta. (863 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa) |
| | IFNGR2-2 | IFNGR2 isoform 6. (302 aa) |
| | BAX | BAX isoform 7. (123 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (208 aa) |
| | LOC742456 | Cytochrome c-like. (105 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
| | CARD9 | Caspase recruitment domain family, member 9. (536 aa) |
