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| | HSPG2 | HSPG2 isoform 1. (4390 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3-like 4. (395 aa) |
| | FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | EGR2 | Early growth response 2. (476 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3-like 1. (519 aa) |
| | DDB2 | Damage-specific DNA binding protein 2, 48kDa. (427 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | TBK1 | TANK-binding kinase 1. (729 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa) |
| | SLC10A1 | Solute carrier family 10 member 1. (349 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (461 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (253 aa) |
| | IFIH1 | IFIH1 isoform 1. (1025 aa) |
| | CASP8 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (449 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | MMP9 | Matrix metallopeptidase 9. (699 aa) |
| | IFNAR1 | Interferon (Alpha, beta and omega) receptor 1. (558 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | ATF4 | Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa) |
| | EP300 | E1A binding protein p300. (2175 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa) |
| | CCNA2 | CCNA2 isoform 1; Belongs to the cyclin family. (432 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TLR3 | Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3-like 2. (520 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | PTK2B | PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | IFNA21 | Interferon alpha 21. (189 aa) |
| | IFNA2 | IFNA2 isoform 1. (170 aa) |
| | IFNA5 | Interferon alpha 5. (189 aa) |
| | DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (925 aa) |
| | TLR4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa) |
| | ELK1 | ELK1, member of ETS oncogene family. (428 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (470 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | NFATC2 | NFATC2 isoform 4. (938 aa) |
| | CASP12 | CASP12 isoform 1; Belongs to the peptidase C14A family. (341 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1509 aa) |
| | TYK2 | Tyrosine-protein kinase. (1184 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | CCNE2 | CCNE2 isoform 1; Belongs to the cyclin family. (404 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (370 aa) |
| | ATF6B | Activating transcription factor 6 beta. (711 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | ENSPTRP00000061486 | Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | CASP10 | CASP10 isoform 4; Belongs to the peptidase C14A family. (523 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TICAM2 | TIR domain-containing adapter molecule 2. (235 aa) |
| | TIRAP | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (235 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | LOC107972317 | Cytochrome c-like. (102 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | IFNA17 | IFNA17 isoform 1. (189 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | CCNA1 | CCNA1 isoform 3; Belongs to the cyclin family. (421 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | IKBKE | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (716 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | LOC100610002 | IKBKG isoform 9. (401 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | CREB5 | CREB5 isoform 1. (508 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | BRAF | BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa) |
| | STAT4 | Signal transducer and activator of transcription. (748 aa) |
| | CK820_G0014527 | IFNA13 isoform 2. (198 aa) |
| | DDB1 | Damage-specific DNA binding protein 1, 127kDa. (1147 aa) |
| | LOC104002760 | Cytochrome c. (110 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | ARAF | V-raf murine sarcoma 3611 viral oncogene homolog. (606 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa) |
| | IFNA8 | Interferon alpha 8. (189 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | LOC741747 | IFNA7 isoform 1. (189 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa) |
| | CCNE1 | CCNE1 isoform 1; Belongs to the cyclin family. (411 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (933 aa) |
| | LOC742651 | IFNA1 isoform 1. (195 aa) |
| | CASP9 | CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa) |
| | BAX | BAX isoform 7. (123 aa) |
| | LOC742456 | Cytochrome c-like. (105 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
